-
公开(公告)号：US20220110884A1
公开(公告)日：2022-04-14
申请号：US17450629
申请日：2021-10-12
Applicant: Translate Bio, Inc.
Inventor： Shrirang Karve , Travis Jeanotte , Monic Shah , Yi Zhang , Kimberly Gillis , Frank DeRosa
Abstract: The present invention provides an improved process for lipid nanoparticle formulation and mRNA encapsulation. In some embodiments, the present invention provides a process of encapsulating messenger RNA (mRNA) in lipid nanoparticles comprising a step of mixing an mRNA solution containing low citrate concentration and a lipid solution at an ambient temperature. Thus, the present invention provides an effective, reliable, energy-saving and cost-effective method of encapsulating mRNA into lipid nanoparticles.
-
公开(公告)号：US20250101481A1
公开(公告)日：2025-03-27
申请号：US18794053
申请日：2024-08-05
Applicant: Translate Bio, Inc.
Inventor： Joseph Parella , Kimberly Gillis , Jonathan Abysalh , Travis Jeannotte , Erik Held , Frank DeRosa , Michael Heartlein , Rebecca Powell
Abstract: The present invention provides, among other things, methods for purifying mRNA based on normal flow filtration for therapeutic use.
-
Patent Agency Ranking
公开(公告)号：US20220133631A1
公开(公告)日：2022-05-05
申请号：US17450628
申请日：2021-10-12
Applicant: Translate Bio, Inc.
Inventor： Monic Shah , Travis Jeanotte , Yi Zhang , Shrirang Karve , Kimberly Gillis , Frank DeRosa
IPC: A61K9/127 , A61K31/7105
Abstract: The present invention provides an improved process for lipid nanoparticle formulation and mRNA encapsulation. In some embodiments, the present invention provides a process of encapsulating messenger RNA (mRNA) in lipid nanoparticles comprising a step of mixing an mRNA solution containing low citrate concentration and a lipid solution at an ambient temperature. Thus, the present invention provides an effective, reliable, energy-saving and cost-effective method of encapsulating mRNA into lipid nanoparticles.
-
公开(公告)号：US11174500B2
公开(公告)日：2021-11-16
申请号：US16551340
申请日：2019-08-26
Applicant: Translate Bio, Inc.
Inventor： Joseph Parella , Kimberly Gillis , Jonathan Abysalh , Travis Jeannotte , Erik Held , Frank DeRosa , Michael Heartlein , Rebecca Powell
Abstract: The present invention provides, among other things, methods for purifying mRNA based on normal flow filtration for therapeutic use.
-
公开(公告)号：US12084702B2
公开(公告)日：2024-09-10
申请号：US17450506
申请日：2021-10-11
Applicant: Translate Bio, Inc.
Inventor： Joseph Parella , Kimberly Gillis , Jonathan Abysalh , Travis Jeannotte , Erik Held , Frank DeRosa , Michael Heartlein , Rebecca Powell
CPC classification number: C12P19/34 , B01D25/00 , B01D37/00 , C07H1/06 , C07H21/02 , C07H21/04 , C12N15/1017 , C12N15/52 , C12N2330/30
Abstract: The present invention provides, among other things, methods for purifying mRNA based on normal flow filtration for therapeutic use.
-
公开(公告)号：US20220170061A1
公开(公告)日：2022-06-02
申请号：US17450506
申请日：2021-10-11
Applicant: Translate Bio, Inc.
Inventor： Joseph Parella , Kimberly Gillis , Jonathan Abysalh , Travis Jeannotte , Erik Held , Frank DeRosa , Michael Heartlein , Rebecca Powell
Abstract: The present invention provides, among other things, methods for purifying mRNA based on normal flow filtration for therapeutic use.
-
公开(公告)号：US20200095571A1
公开(公告)日：2020-03-26
申请号：US16551340
申请日：2019-08-26
Applicant: Translate Bio, Inc.
Inventor： Joseph Parella , Kimberly Gillis , Jonathan Abysalh , Travis Jeannotte , Erik Held , Frank DeRosa , Michael Heartlein , Rebecca Powell
IPC: C12N15/10
Abstract: The present invention provides, among other things, methods for purifying mRNA based on normal flow filtration for therapeutic use.
-
-
-
-
-
-
Search Results
7
records
(took 0.015 seconds)
