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    Recombinant enterovirus 71 neutralizing antibodies and applications thereof
    1.
    发明授权
    Recombinant enterovirus 71 neutralizing antibodies and applications thereof 有权
    重组肠病毒71中和抗体及其应用

    公开(公告)号：US07482006B2

    公开(公告)日：2009-01-27

    申请号：US11404770

    申请日：2006-04-17

    申请人： Tse-Wen Chang ,  Jim Jinn-Chyuan Sheu ,  Lee-Hwa Lo ,  Nien-Yi Chen ,  Young-Sun Lin

    发明人： Tse-Wen Chang ,  Jim Jinn-Chyuan Sheu ,  Lee-Hwa Lo ,  Nien-Yi Chen ,  Young-Sun Lin

    IPC分类号： A61K39/42 ,  C12P21/08 ,  C12N15/13 ,  C07K16/10

    CPC分类号： C07K16/1009 ,  A61K2039/505 ,  C07K2317/21 ,  C07K2317/52 ,  C07K2317/622 ,  C07K2319/00

    摘要： Provided is an antibody against enterovirus 71 comprising the amino acid sequence shown in SEQ ID NOS: 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25, or 26 or functionally active homologues thereof. Also provided are methods for obtaining the antibody comprising (a) selecting a yeast expressing such an antibody from a yeast library, (b) culturing the yeast under conditions that the antibody is expressed, and (c) recovering the antibody from the culture. Also provided is a process for producing the antibody comprising (a) culturing a host cell under conditions that the antibody is expressed, (b) recovering the antibody from the culture, wherein the host cells are transformed or transfected for expressing the antibody against enterovirus 71. Also provided are pharmaceutical compositions comprising an antibody against enterovirus 71 and a pharmaceutically acceptable carrier or diluent, wherein the antibody has an anti-virus agent or detectable label attached thereto.

    摘要翻译： 本发明提供了包含SEQ ID NO：14,15,16,17,18,19,20,21,22,23,24,25或26所示氨基酸序列的肠道病毒71抗体或其功能活性同系物。 还提供了获得抗体的方法，其包括（a）从酵母文库中选择表达这种抗体的酵母，（b）在表达抗体的条件下培养酵母，和（c）从培养物中回收抗体。 还提供了制备抗体的方法，其包括（a）在表达抗体的条件下培养宿主细胞，（b）从培养物中回收抗体，其中宿主细胞被转化或转染用于表达针对肠道病毒的抗体71 还提供了包含针对肠病毒71的抗体和药学上可接受的载体或稀释剂的药物组合物，其中所述抗体具有附着于其上的抗病毒剂或可检测标记。