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    Thienopyridine derivatives, their production and use
    1.
    发明授权
    Thienopyridine derivatives, their production and use 失效
    噻吩并吡啶衍生物，其生产和使用

    公开(公告)号：US06653476B2

    公开(公告)日：2003-11-25

    申请号：US10204593

    申请日：2002-08-22

    申请人： Tsuneo Yasuma ,  Atsuo Baba ,  Haruhiko Makino ,  Isao Aoki ,  Toshiaki Nagata

    发明人： Tsuneo Yasuma ,  Atsuo Baba ,  Haruhiko Makino ,  Isao Aoki ,  Toshiaki Nagata

    IPC分类号： A61K314365

    CPC分类号： C07D495/04 ,  C07D495/14

    摘要： The present invention provides thienopyridine derivatives, which are useful as anti-inflammatory drugs, particularly as remedies for arthritis; processes for producing them, and pharmaceutical compositions containing them. The thienopyridine derivatives are represented by the formula (I): wherein G is a halogen atom, hydroxyl group, an optionally substituted amino group, etc.; alk is an optionally substituted lower alkylene group; X is O, S, —(CH2)q—, etc.; R is an optionally substituted amino group, etc.; ring B is an optionally substituted Y-containing 5- to 8-membered ring whose ring constituent atoms contain no nitrogen atom; Y is O, S, a group of (wherein Ra, Rb and Rc are the same or different and, each is H, a halogen atom, an optionally substituted hydrocarbon group, etc.), etc.; and ring A may be substituted.

    摘要翻译： 本发明提供可用作抗炎药物的噻吩并吡啶衍生物，特别是作为关节炎的补救剂; 制备它们的方法和含有它们的药物组合物。 噻吩并吡啶衍生物由式（I）表示：其中G是卤素原子，羟基，任选取代的氨基等; 烷基是任选取代的低级亚烷基; X是O，S， - （CH 2）q - 等; R是任选取代的氨基等; 环B是任选取代的含有Y的5至8元环，其环组成原子不含氮原子; Y是O，S，（其中Ra，Rb和Rc相同或不同，并且各自为H，卤素原子，任选取代的烃基等）等; 并且环A可以被取代。

    Thienopyridine derivatives, their production and use
    2.
    发明授权
    Thienopyridine derivatives, their production and use 失效
    噻吩并吡啶衍生物，其生产和使用

    公开(公告)号：US07067527B2

    公开(公告)日：2006-06-27

    申请号：US10662165

    申请日：2003-09-03

    申请人： Tsuneo Yasuma ,  Atsuo Baba ,  Haruhiko Makino ,  Isao Aoki ,  Toshiaki Nagata

    发明人： Tsuneo Yasuma ,  Atsuo Baba ,  Haruhiko Makino ,  Isao Aoki ,  Toshiaki Nagata

    IPC分类号： C07D495/14 ,  A61K31/38

    CPC分类号： C07D495/04 ,  C07D495/14

    摘要： The present invention provides thienopyridine derivatives, which are useful as anti-inflammatory drugs, particularly as remedies for arthritis; processes for producing them, and pharmaceutical compositions containing them. The thienopyridine derivatives are represented by the formula (I): wherein G is a halogen atom, hydroxyl group, an optionally substituted amino group, etc.; alk is an optionally substituted lower alkylene group; X is O, S, —(CH2)q—, etc.; R is an optionally substituted amino group, etc.; ring B is an optionally substituted Y-containing 5- to 8-membered ring whose ring constituent atoms contain no nitrogen atom; Y is O, S, a group of (wherein Ra, Rb and Rc are the same or different and, each is H, a halogen atom, an optionally substituted hydrocarbon group, etc.), etc.; and ring A may be substituted.

    摘要翻译： 本发明提供可用作抗炎药物的噻吩并吡啶衍生物，特别是作为关节炎的补救剂; 制备它们的方法和含有它们的药物组合物。 噻吩并吡啶衍生物由式（I）表示：其中G是卤素原子，羟基，任选取代的氨基等; 烷基是任选取代的低级亚烷基; X是O，S， - （CH 2 CH 2）q - 等; R是任选取代的氨基等; 环B是任选取代的含有Y的5至8元环，其环组成原子不含氮原子; Y是O，S，（其中Ra，Rb和Rc相同或不同，并且各自为H，卤素原子，任选取代的烃基等）等; 并且环A可以被取代。

    Thienopyridine Derivatives, Production Method and Use Thereof
    3.
    发明申请
    Thienopyridine Derivatives, Production Method and Use Thereof 审中-公开
    噻吩并吡啶衍生物，其生产方法和用途

    公开(公告)号：US20080146602A1

    公开(公告)日：2008-06-19

    申请号：US11596634

    申请日：2005-05-13

    申请人： Atsuo Baba ,  Tsuneo Yasuma ,  Hiroyuki Tawada ,  Makoto Yamashita

    发明人： Atsuo Baba ,  Tsuneo Yasuma ,  Hiroyuki Tawada ,  Makoto Yamashita

    IPC分类号： A61K31/4365 ,  C07D471/04 ,  A61P19/02

    CPC分类号： C07D495/04

    摘要： A compound represented by the formula (I) wherein R is a hydrogen atom or a C1-4 alkyl group, and X is CH2, O or S, or a salt thereof. The present invention provides a novel thienopyridine derivative having an anti-inflammatory effect, a bone resorption suppressing effect, an immune cytokine production suppressing effect and the like, and useful as a pharmaceutical agent such as an agent for the prophylaxis or treatment of arthritis such as rheumatoid arthritis and the like, and the like, and the like.

    摘要翻译： 由式（I）表示的化合物，其中R是氢原子或C 1-4烷基，X是CH 2，O或S，或 的盐。 本发明提供具有抗炎作用，骨吸收抑制作用，免疫细胞因子产生抑制作用等的新颖的噻吩并吡啶衍生物，可用作预防或治疗关节炎的药剂如 类风湿关节炎等，类似物等。

    Benzothiepin derivatives, process for the preparation of the same and uses thereof
    4.
    发明授权
    Benzothiepin derivatives, process for the preparation of the same and uses thereof 失效
    苯并噻吩衍生物，其制备方法及其用途

    公开(公告)号：US06355672B1

    公开(公告)日：2002-03-12

    申请号：US09744857

    申请日：2001-01-30

    申请人： Tsuneo Yasuma ,  Haruhiko Makino ,  Akira Mori

    发明人： Tsuneo Yasuma ,  Haruhiko Makino ,  Akira Mori

    IPC分类号： C07D33708

    CPC分类号： C07D263/44 ,  C07D211/88 ,  C07D233/74 ,  C07D277/04 ,  C07D295/135 ,  C07D495/04

    摘要： The invention provides compounds of the formula: wherein the ring A is an optionally substituted benzene ring; R1 is an optionally substituted non-aromatic heterocyclic group; R2 and R3 are independently hydrogen atom or an optionally substituted hydrocarbon group; n is an integer of 0-3; or salts thereof, which are useful as medicines having an osteogenesis promoting effect and chondrogensis promoting effect. The present invention relates to an amine compound having an excellent effect of inhibiting production and/or secretion of amyloid-b protein, a production and use thereof. Especially, it is effective for preventing and/or treating, for example, neurodegenerative diseases, amyloid angiopathy, neurological disorders caused by cerebrovascular disorders, and so forth.

    摘要翻译： 本发明提供下式的化合物：其中环A是任选取代的苯环; R1是任选取代的非芳族杂环基; R2和R3独立地为氢原子或任选取代的烃基; n为0-3的整数; 或其盐，其可用作具有成骨促进作用的药物和软骨素促进作用。本发明涉及具有抑制淀粉样蛋白b蛋白的产生和/或分泌的优异效果的胺化合物及其制备和用途。 特别地，对于预防和/或治疗例如神经变性疾病，淀粉样血管病，由脑血管障碍引起的神经障碍等是有效的。

    Benzothiepine derivatives, their production and use
    5.
    发明授权
    Benzothiepine derivatives, their production and use 失效
    苯并噻吩衍生物，其生产和使用

    公开(公告)号：US06531604B2

    公开(公告)日：2003-03-11

    申请号：US10044787

    申请日：2002-01-11

    申请人： Tsuneo Yasuma ,  Haruhiko Makino ,  Akira Mori

    发明人： Tsuneo Yasuma ,  Haruhiko Makino ,  Akira Mori

    IPC分类号： C07D21140

    CPC分类号： C07D263/44 ,  C07D211/88 ,  C07D233/74 ,  C07D277/04 ,  C07D295/135 ,  C07D495/04

    摘要： The invention provides compounds of the formula: wherein the ring A is an optionally substituted benzene ring; R1 is an optionally substituted non-aromatic heterocyclic group; R2 and R3 are independently hydrogen atom or an optionally substituted hydrocarbon group; n is an integer of 0-3; or salts thereof, which are useful as medicines having an osteogenesis promoting effect and chondrogensis promoting effect. The present invention relates to an amine compound having an excellent effect of inhibiting production and/or secretion of amyloid-b protein, a production and use thereof. Especially, it is effective for preventing and/or treating, for example, neurodegenerative diseases, amyloid angiopathy, neurological disorders caused by cerebrovascular disorders, and so forth.

    摘要翻译： 本发明提供下式的化合物：其中环A是任选取代的苯环; R1是任选取代的非芳族杂环基; R2和R3独立地为氢原子或任选取代的烃基; n为0-3的整数; 或其盐，其可用作具有成骨促进作用的药物和软骨素促进作用。本发明涉及具有抑制淀粉样蛋白b蛋白的产生和/或分泌的优异效果的胺化合物及其制备和用途。 特别地，对于预防和/或治疗例如神经变性疾病，淀粉样血管病，由脑血管障碍引起的神经障碍等是有效的。

    Indole compound
    10.
    发明授权
    Indole compound 失效

    公开(公告)号：US07652133B2

    公开(公告)日：2010-01-26

    申请号：US11907929

    申请日：2007-10-18

    申请人： Tsuneo Yasuma

    发明人： Tsuneo Yasuma

    IPC分类号： C07D417/04

    CPC分类号： C07D417/14

    摘要： The purpose of the present invention is to provide a glucokinase activator useful as a pharmaceutical agent such as an agent for the prophylaxis or treatment of diabetes, obesity and the like.The present invention provides a glucokinase activator containing a compound represented by the formula (I): wherein R1 is a hydrogen atom or a halogen atom; R2 is a group represented by wherein each symbol is defined in the specification, or a salt thereof or a prodrug thereof.