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公开(公告)号:US06723857B1
公开(公告)日:2004-04-20
申请号:US10019670
申请日:2002-01-02
IPC分类号: C07D33350
CPC分类号: C07F7/188 , C07B2200/07 , C07C67/343 , C07C213/00 , C07C213/02 , C07C215/42 , C07C249/08 , C07C2602/42 , C07D333/68 , C07D333/70 , C07F7/1804 , C07C69/716 , C07C251/44 , C07C251/50
摘要: The present invention provides a process for the preparation of a bicyclic aminoalcohol which comprises reacting a starting compound, nopinone (I), with XCH2COOR1 wherein X is halogen, and R1 is alkyl, in the presence of an additive and a base to produce a compound (II), converting it to oxime derivative (III), and reducing it with an aluminum hydride.
摘要翻译: 本发明提供了一种制备双环氨基醇的方法,其包括在添加剂存在下使起始化合物,诺酮酮(I)与X为卤素的XCH 2 COOR 1和R 1为烷基, 制备化合物(II)的碱,将其转化为肟衍生物(III),并用氢化铝还原。