专利检索 ap:("Tufts University" OR "Boston Medical Center Corporation" OR "The Regents of the University of California") AND inv:"Paola Massari" 第 1 页

1.

发明授权
Methods and compositions for vaccinating a subject for a sexually transmitted pathogen 有权

公开(公告)号：US09987346B2

公开(公告)日：2018-06-05

申请号：US15448767

申请日：2017-03-03

申请人： Tufts University , Boston Medical Center Corporation , The Regents of the University of California

发明人： Paola Massari , Guillermo Madico , Luis de la Maza

IPC分类号： A61K39/00 , A61K39/02 , A61K39/118 , C07K14/22 , C07K14/295

CPC分类号： A61K39/118 , A61K2039/55561 , A61K2039/55566 , A61K2039/575 , A61K2039/6068 , C07K14/22 , C07K14/295

摘要： Purified Chlamydia major outer membrane protein (MOMP) has been observed to induce protection against genital and respiratory challenge in mice. MOMP contains variable domains that are highly immunogenic and elicit cross-serovar neutralizing monoclonal and polyclonal antibodies and T cell responses in animal and human models. Examples herein provide a method for vaccinating a subject against Chlamydia using a composition that is a recombinant Neisseria porin that contains at least one antigenic variable domain of Chlamydia. The variable domains are inserted into the amino acid sequence of the Neisseria porin at a position encoding a surface-exposed loop of the Neisseria porin. The vaccine further contains an adjuvant that induces a Th1 response greater than a Th2 response.

2.

发明申请
Methods and compositions for vaccinating a subject for a sexually transmitted pathogen 有权

公开(公告)号：US20170252424A1

公开(公告)日：2017-09-07

申请号：US15448767

申请日：2017-03-03

申请人： Tufts University , Boston Medical Center Corporation , The Regents of the University of California

发明人： Paola Massari , Guillermo Madico , Luis de la Maza

IPC分类号： A61K39/118 , C12N15/70 , C12P21/02

CPC分类号： A61K39/118 , A61K2039/55561 , A61K2039/55566 , A61K2039/575 , A61K2039/6068 , C07K14/22 , C07K14/295

摘要： Purified Chlamydia major outer membrane protein (MOMP) has been observed to induce protection against genital and respiratory challenge in mice. MOMP contains variable domains that are highly immunogenic and elicit cross-serovar neutralizing monoclonal and polyclonal antibodies and T cell responses in animal and human models. Examples herein provide a method for vaccinating a subject against Chlamydia using a composition that is a recombinant Neisseria porin that contains at least one antigenic variable domain of Chlamydia. The variable domains are inserted into the amino acid sequence of the Neisseria porin at a position encoding a surface-exposed loop of the Neisseria porin. The vaccine further contains an adjuvant that induces a Th1 response greater than a Th2 response.