公开(公告)号：US09617302B2

公开(公告)日：2017-04-11

申请号：US14126808

申请日：2012-06-14

申请人： Tur-Fu Huang ,  Chien-Hsin Chang ,  Ching-Hu Chung

发明人： Tur-Fu Huang ,  Chien-Hsin Chang ,  Ching-Hu Chung

IPC分类号： A61K38/08 ,  A61K45/06 ,  C07K7/06 ,  C07K7/08 ,  C07K7/64 ,  C07K14/705 ,  A61K38/00

CPC分类号： C07K7/06 ,  A61K9/0019 ,  A61K38/00 ,  A61K38/08 ,  A61K45/06 ,  A61L33/0011 ,  A61L2300/42 ,  C07K5/12 ,  C07K7/08 ,  C07K7/64 ,  C07K14/705

摘要： The invention relates to a peptide compound and its pharmaceutical composition for inhibiting platelet aggregation and preventing/treating thrombogenic diseases. The invention develops pentapeptides and hexapeptides derived from snake venom C-type lectin-like proteins (CLPs) fragments, which can inhibit platelet aggregation and have antithrombotic activity without hemorrhagic tendency. Accordingly, they can be used as potential agents for the prevention and therapy of thrombogenic diseases.

公开(公告)号：US20140363423A1

公开(公告)日：2014-12-11

申请号：US14126808

申请日：2012-06-14

申请人： Tur-Fu Huang ,  Chien-Hsin Chang ,  Ching-Hu Chung

发明人： Tur-Fu Huang ,  Chien-Hsin Chang ,  Ching-Hu Chung

IPC分类号： C07K7/06 ,  A61K45/06 ,  A61K38/08 ,  C07K7/08 ,  C07K7/64

CPC分类号： C07K7/06 ,  A61K9/0019 ,  A61K38/00 ,  A61K38/08 ,  A61K45/06 ,  A61L33/0011 ,  A61L2300/42 ,  C07K5/12 ,  C07K7/08 ,  C07K7/64 ,  C07K14/705

摘要： The invention relates to a peptide compound and its pharmaceutical composition for inhibiting platelet aggregation and preventing/treating thrombogenic diseases. The invention develops pentapeptides and hexapeptides derived from snake venom C-type lectin-like proteins (CLPs) fragments, which can inhibit platelet aggregation and have antithrombotic activity without hemorrhagic tendency. Accordingly, they can be used as potential agents for the prevention and therapy of thrombogenic diseases.

摘要翻译： 本发明涉及一种肽化合物及其用于抑制血小板聚集和预防/治疗血栓形成疾病的药物组合物。 本发明开发衍生自蛇毒C型凝集素样蛋白（CLPs）片段的五肽和六肽，其可以抑制血小板聚集并具有抗血栓形成活性而没有出血倾向。 因此，它们可以用作预防和治疗血栓形成疾病的潜在剂。