公开(公告)号：US20200024346A1

公开(公告)日：2020-01-23

申请号：US16513002

申请日：2019-07-16

申请人： UCB BIOPHARMA SPRL

发明人： Helene Margaret FINNEY ,  Stephen Edward RAPECKI ,  Michael John WRIGHT ,  Kerry Louise TYSON

IPC分类号： C07K16/28 ,  C07K16/18

摘要： The present disclosure relates to multispecific molecule comprising a binding domain specific to the antigen CD22 and a binding domain specific to the antigen CD79a and/or CD79b, compositions comprising the same and use of both in treatment, for example the treatment of autoimmune disease.

公开(公告)号：US20190322739A1

公开(公告)日：2019-10-24

申请号：US16402097

申请日：2019-05-02

申请人： UCB BIOPHARMA SPRL

发明人： Helene Margaret FINNEY ,  Stephen Edward RAPECKI ,  Michael John WRIGHT

IPC分类号： C07K16/28 ,  C07K16/14 ,  C07K16/46 ,  C07K16/00 ,  G01N33/68

摘要： The present disclosure relates to a novel bispecific protein complex and a method of using the complexes to screen for synergistic or novel biological function. The bispecific format is particularly suitable for high-throughput screening because all of its components can be expressed from cells as individual units and the units can be assembled simply by mixing without employing conjugation or coupling chemistry.

公开(公告)号：US20180273620A1

公开(公告)日：2018-09-27

申请号：US15743756

申请日：2016-07-15

申请人： UCB Biopharma SPRL

发明人： Helene Margaret FINNEY ,  Stephen Edward RAPECKI ,  Kerry Louise TYSON ,  Michael John WRIGHT

IPC分类号： C07K16/28

摘要： The present disclosure relates to antibody molecules comprising a binding domain specific to CD22, said binding domain comprising SEQ ID NO: 1, 2, 3, 4, 5 and 6 or 7. The disclosure also extends to pharmaceutical compositions comprising said antibody molecules and use of the antibody molecules/compositions in treatment.

公开(公告)号：US20180346603A1

公开(公告)日：2018-12-06

申请号：US15779417

申请日：2016-12-01

申请人： UCB BIOPHARMA SPRL

发明人： Pallavi BHATTA ,  Laura STARKIE ,  Michael John WRIGHT

IPC分类号： C07K16/46 ,  C07K16/14 ,  C07K14/395 ,  C12N15/10

CPC分类号： C07K16/00 ,  C07K14/395 ,  C07K16/14 ,  C07K16/468 ,  C07K2319/00 ,  C07K2319/21 ,  C07K2319/23

摘要： The present invention relates to heterodimerically-tethered bispecific protein complexes (according to the general formula of A-X:Y-B) and libraries/multiplexes thereof for use in research and therapy and in particular an in vitro/ex vivo method of detecting synergistic biological function of otherwise unknown pairs of targets.

公开(公告)号：US20180334514A1

公开(公告)日：2018-11-22

申请号：US15779424

申请日：2016-12-01

申请人： UCB BIOPHARMA SPRL

发明人： Michael John WRIGHT

IPC分类号： C07K16/46

摘要： The present invention relates to heterodimerically-tethered bispecific protein complexes (according to the general formula of A(A1)n-X:Y-B(B1)m and libraries/multiplexes thereof for use in research and therapy and in particular an in vitro/ex vivo method of detecting synergistic biological function of otherwise unknown pairs of targets. Such complexes may be used to capture soluble molecules secreted from a particular cell, in therapy, in research and for experimental purposes such as in assays to characterise patient populations by identifying cell populations relevant to a pathology or prognosis.

公开(公告)号：US20180334513A1

公开(公告)日：2018-11-22

申请号：US15779421

申请日：2016-12-01

申请人： UCB BIOPHARMA SPRL

发明人： Michael John WRIGHT

IPC分类号： C07K16/46

CPC分类号： C07K16/468 ,  C07K16/00 ,  C07K16/14 ,  C07K2317/55 ,  C07K2317/622 ,  C07K2319/00

摘要： The present invention relates to heterodimerically-tethered bispecific protein complexes (according to the general formula of (A-X)2:(Y-B)2) and libraries/multiplexes thereof for use in research and therapy and in particular an in vitro/ex vivo method of detecting synergistic biological function of otherwise unknown pairs of targets. Such complexes may be used to capture soluble molecules secreted from a particular cell, in therapy, in research and for experimental purposes such as in assays to characterise patient populations by identifying cell populations relevant to a pathology or prognosis.

公开(公告)号：US20180237521A1

公开(公告)日：2018-08-23

申请号：US15743761

申请日：2016-07-15

申请人： UCB Biopharma SPRL

发明人： Helene Margaret FINNEY ,  Stephen Edward RAPECKI ,  Kerry Louise TYSON ,  Michael John WRIGHT

IPC分类号： C07K16/28 ,  C07K16/18

CPC分类号： C07K16/289 ,  C07K16/18 ,  C07K16/2803 ,  C07K2317/24 ,  C07K2317/31 ,  C07K2317/35 ,  C07K2317/55 ,  C07K2317/622 ,  C07K2317/624 ,  C07K2317/64 ,  C07K2317/76 ,  C07K2317/90

摘要： The present disclosure relates to constructs, such as antibody molecules comprising a binding domain specific to CD45, said binding domain comprising SEQ ID NO: 1, 2, 3 and/or SEQ ID NO: 4, 5 and 6. The disclosure also extends to pharmaceutical compositions comprising said constructs and use of the constructs/compositions in treatment.

公开(公告)号：US20180201678A1

公开(公告)日：2018-07-19

申请号：US15743764

申请日：2016-07-15

申请人： UCB Biopharma SPRL

发明人： Helene Margaret FINNEY ,  Stephen Edward RAPECKI ,  Kerry Louise TYSON ,  Michael John WRIGHT

IPC分类号： C07K16/28

CPC分类号： C07K16/2803 ,  A61K47/6809 ,  A61K47/6849 ,  A61K47/6867 ,  C07K16/18 ,  C07K16/289 ,  C07K16/2896 ,  C07K2317/24 ,  C07K2317/31 ,  C07K2317/33 ,  C07K2317/35 ,  C07K2317/55 ,  C07K2317/622 ,  C07K2317/64 ,  C07K2317/76

摘要： The present disclosure relates to antibody molecules comprising a binding domain specific to CD79, said binding domain comprising SEQ ID NO: 1, 2, 3 or 4, and/or SEQ ID NO: 5, 6 and 7. The disclosure also extends to pharmaceutical compositions comprising said antibody molecules and use of the antibody molecules/compositions in treatment.