公开(公告)号：US3759928A

公开(公告)日：1973-09-18

申请号：US3759928D

申请日：1970-06-02

申请人： UCB SA

发明人： ZIVKOVIC D

IPC分类号： C07D211/70 ,  C07D29/12

CPC分类号： C07D211/70 ,  Y10S514/821 ,  Y10S514/872

摘要： WHEREIN A1, A2, A3, A4, A5 and B, taken separately, each represents hydrogen, halogen, halomethyl, alkyl, alkoxy, nitro, cyano or amino, and A5 and B, taken together, represent a bivalent radical selected from the group consisting of alkylene, alkenylene and alkadienylene having 3 to 5 carbon atoms and alkylene dioxy having 1 to 3 carbon atoms, said bivalent radical being connected to two adjacent carbon atoms of the benzene nucleus, WITH THE PROVISO THAT WHEN A1, A2, A3, A4, A5 and B are all hydrogen atoms, the diphenyl-methylene radical is in the ortho or meta position with regard to the nitrogen atom in the piperidine nucleus, AND THE ADDITION SALTS THEREOF WITH PHARMACEUTICALLY ACCEPTABLE INORGANIC OR ORGANIC ACIDS.

Blood circulation activating, anti-arrhythmic and antihistaminic diphenyl-methylene-N-benzyl-piperidines having the general formula

摘要翻译： 具有通式为A1，A2，A3，A4，A5和B的血液循环活化，抗心律不齐和抗组胺二苯基 - 亚甲基-N-苄基 - 哌啶分别代表氢，卤素，卤代甲基，烷基，烷氧基， 硝基，氰基或氨基，并且A 5和B一起代表选自具有3至5个碳原子的亚烷基，亚烯基和亚烷基二烯基以及具有1至3个碳原子的亚烷基二氧基的二价基团，所述二价基团连接 对于苯核的两个相邻的碳原子，当A1，A2，A3，A4，A5和B都是氢原子时，二苯基 - 亚甲基相对于氮原子在邻位或间位 哌啶核，以及其与药物接受无机或有机酸的添加剂。