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公开(公告)号：US11492408B2
公开(公告)日：2022-11-08
申请号：US15028113
申请日：2014-10-10
Applicant: UCL BUSINESS LTD
Inventor： Martin Pulé , Kwee Yong , Lydia Lee , Neil Chaplin
IPC: C07K16/28
Abstract: The present invention provides a bi-specific molecule which comprises: (i) a first domain which binds B cell maturation antigen (BCMA) and comprises at least part of a proliferation-inducing ligand (APRIL); and (ii) a second domain capable of activating a T cell. The invention also provides the use of such a molecule in the treatment of plasma-cell mediated diseases, such as multiple myeloma.
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