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15 条记录 (耗时 0.013 秒)

    SIGNALLING SYSTEM
    6.
    发明申请
    SIGNALLING SYSTEM 有权

    公开(公告)号：US20210032332A1

    公开(公告)日：2021-02-04

    申请号：US16848717

    申请日：2020-04-14

    申请人： UCL BUSINESS LTD

    发明人： Martin Pulé ,  Shaun Cordoba ,  Khai Kong

    IPC分类号： C07K16/28 ,  A61K35/17 ,  C07K14/725 ,  C12N5/0783 ,  A61K31/65 ,  C07K14/73

    摘要： The present invention provides a chimeric antigen receptor (CAR) signalling system comprising; (i) a receptor component comprising an antigen binding domain, a transmembrane domain and a first binding domain; and (ii) an intracellular signalling component comprising a signalling domain and a second binding domain which specifically binds the first binding domain of the receptor component; wherein, binding of the first and second binding domains is disrupted by the presence of an agent, such that in the absence of the agent the receptor component and the signalling component heterodimerize and binding of the antigen binding domain to antigen results in signalling through the signalling domain, whereas in the presence of the agent the receptor component and the signalling component do not heterodimerize and binding of the antigen binding domain to antigen does not result in signalling through the signalling domain.

    Chimeric Antigen Receptor
    7.
    发明申请
    Chimeric Antigen Receptor 审中-公开

    公开(公告)号：US20200254021A1

    公开(公告)日：2020-08-13

    申请号：US16796370

    申请日：2020-02-20

    申请人： UCL Business LTD

    发明人： Martin Pulé ,  Anne Kramer ,  Evangelia K. Kokalaki

    IPC分类号： A61K35/17 ,  C07K14/705 ,  C07K14/725 ,  C07K16/28

    摘要： The present invention provides a chimeric antigen receptor (CAR) comprising an antigen-binding domain with an affinity in the range of 50 nM to 500 nM, wherein said affinity comprises component kinetics such that the association rate constant (kon) is greater than or equal to 1×105 M−1 S−1, and/or the dissociation rate constant (koff) is greater than or equal to 0.01 s−1.

    CHIMERIC PROTEIN
    9.
    发明申请
    CHIMERIC PROTEIN 审中-公开

    公开(公告)号：US20200222461A1

    公开(公告)日：2020-07-16

    申请号：US16598652

    申请日：2019-10-10

    申请人： UCL BUSINESS LTD

    发明人： Martin Pulé ,  Ryan Trowbridge ,  Edward Hodgkin

    IPC分类号： A61K35/17 ,  C12N9/64 ,  A61K31/436 ,  C12N15/62 ,  C07K14/705 ,  C12N9/12

    摘要： The present invention provides a chimeric protein having the formula: Casp-Ht1-Ht2 wherein Casp is a caspase domain; Ht1 is a first heterodimerization domain; and Ht2 is a second heterodimerization domain and wherein, in the presence of a chemical inducer of dimcrization (CID), an identical pair of the chimeric proteins interact such that Ht1 from one chimeric protein heterodimerizes with Ht2 from the other chimeric protein, causing homodimerization of the two caspase domains. The invention also provides a cell comprising such a protein and its use in adoptive cell therapy.

    Bi-specific T-cell engager specific for BCMA
    10.
    发明授权
    Bi-specific T-cell engager specific for BCMA 有权

    公开(公告)号：US11492408B2

    公开(公告)日：2022-11-08

    申请号：US15028113

    申请日：2014-10-10

    申请人： UCL BUSINESS LTD

    发明人： Martin Pulé ,  Kwee Yong ,  Lydia Lee ,  Neil Chaplin

    IPC分类号： C07K16/28

    摘要： The present invention provides a bi-specific molecule which comprises: (i) a first domain which binds B cell maturation antigen (BCMA) and comprises at least part of a proliferation-inducing ligand (APRIL); and (ii) a second domain capable of activating a T cell. The invention also provides the use of such a molecule in the treatment of plasma-cell mediated diseases, such as multiple myeloma.