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公开(公告)号：US20240345086A1
公开(公告)日：2024-10-17
申请号：US18579635
申请日：2022-07-20
申请人： UCL Business LTD
发明人： Kevin Mills , Wendy Heywood , Ivan Doykov , James Moon
IPC分类号： G01N33/569 , G01N33/68
CPC分类号： G01N33/56983 , G01N33/6848 , G01N2333/165 , G01N2469/20
摘要： The present invention relates to a high throughput targeted proteomics-based method for identifying and quantifying one or more binding molecules in a biological fluid of an individual. The present invention involves the use of a plurality of bait molecules to capture the binding molecules. The invention uses proteomics techniques, such as mass spectrometry, for the identification and quantification of the binding molecules. The methods of the invention can be used to identify and quantify antibodies produced by an individual, and proteins expressed by an individual, following exposure to antigens, such as viral antigens, particularly coronavirus antigens and more particularly SARS-CoV-2. Exposure may be via vaccination or following natural infection. The methods of the invention can be used to identify and quantify molecules which bind to a range of proteins of interest, such as autoantigens and neoantigens, as well as to viral vectors.
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公开(公告)号：US12102431B2
公开(公告)日：2024-10-01
申请号：US17054189
申请日：2018-05-25
IPC分类号： A61B5/18 , A61B5/00 , A61B5/145 , A61B5/1455
CPC分类号： A61B5/14553 , A61B5/0048 , A61B5/14546 , A61B5/18 , A61B5/4064
摘要： A method of determining the perceptual load of a human brain. The perceptual load is induced by a predetermined task carried out by the human. The method includes the steps of: measuring with a functional near-infrared spectroscopy (fNIRS) sensor device a metabolic activity of the human brain while the task is carried out and determining the perceptual load as a function of a measured change in metabolic activity. The invention further relates to a method of determining the level of stimulus perception corresponding systems.
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公开(公告)号：US20240310619A1
公开(公告)日：2024-09-19
申请号：US18257389
申请日：2021-12-07
申请人： UCL BUSINESS LTD
CPC分类号： G02B21/367 , G02B21/26 , G06T7/0012 , G06V20/693 , G06T2207/10056 , G06T2207/20081 , G06T2207/20084
摘要： A computer implemented method of controlling a microscope (632) is provided. The method comprises capturing an image (631) within a field of view of a lens of the microscope (632) configured to view a sample on a motorised stage (633) of the microscope (632). The image comprises a portion of the sample. The image (631) is provided to an artificial neural network (610). An action (611) for moving the motorised stage (633) is determined in dependence on an output of the artificial neural network (610). The motorised stage (633) is moved automatically in accordance with the action (611).
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公开(公告)号：US20240280530A1
公开(公告)日：2024-08-22
申请号：US18570995
申请日：2022-06-17
申请人： UCL BUSINESS LTD
发明人： Stefan HOWORKA , Yongzheng XING
IPC分类号： G01N27/327
CPC分类号： G01N27/3278
摘要： A membrane-spanning actuatable nucleic acid nanopore is provided. The nanopore comprises: one or more polynucleotide strands that provide a scaffold component and a plurality of polynucleotide strands that provide a plurality of staple components wherein each of the plurality of staple components hybridise to the scaffold component; and a trigger that is actuatable in response to a stimulus. Actuation of the trigger results in a detectable conformational change of the nanopore from a first conformation to at least a second conformation. Detection may be via a signal change, such as via fluorescence (e.g. FRET) or a change in an electrical signal readout. Semi-fluid membranes, and sensor devices comprising the actuatable nucleic acid nanopores are also provided.
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公开(公告)号：US12064087B2
公开(公告)日：2024-08-20
申请号：US17205941
申请日：2021-03-18
申请人： UCL Business LTD.
发明人： Danail Stoyanov , Agostino Stilli
CPC分类号： A61B1/041 , A61B1/00027 , A61B1/00112 , A61B1/00156 , A61B2562/0247
摘要： An apparatus for capsule endoscopy, the apparatus comprising a capsule that comprises: at least one inflatable bladder configured to form a toroid having a hole and an outer periphery when inflated; a plurality of continuous tracks, each extending through the hole and around the outer periphery of the at least one inflatable bladder; and a propulsion system configured to drive the continuous tracks; wherein the capsule is configured such that the continuous tracks slip over the at least one inflatable bladder when driven by the propulsion system.
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公开(公告)号：US20240272138A1
公开(公告)日：2024-08-15
申请号：US18570947
申请日：2022-06-17
申请人： UCL BUSINESS LTD
发明人： Stefan HOWORKA , Yongzheng XING , Adam DOREY
IPC分类号： G01N33/487 , C12Q1/6804 , G01N33/566
CPC分类号： G01N33/48721 , C12Q1/6804 , G01N33/566
摘要： A sensing nucleic acid nanopore is provided. The nanopore possesses a geometry and wherein the nanopore defines a central lumen passing therethrough. The geometry of the nanopore is configured to accommodate all or a part of an analyte molecule within, or proximate to, the central lumen so as to optimize obstruction of the central lumen by the analyte molecule. Methods for enhancing binding of an analyte molecule to a membrane-spanning nanopore are provided. Membranes, sensor devices and methods for molecular sensing comprising the sensing nucleic acid nanopores are also provided.
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公开(公告)号：US20240199478A1
公开(公告)日：2024-06-20
申请号：US18279239
申请日：2022-03-02
申请人： UCL BUSINESS LTD
发明人： Manish Tiwari , Vikaramjeet Singh
IPC分类号： C03C17/28 , C08K5/56 , C09D5/16 , C09D183/04
CPC分类号： C03C17/28 , C09D5/1625 , C09D5/1675 , C09D183/04 , C03C2217/76 , C03C2218/32 , C08K5/56
摘要： Described are substrates having an amhiphobic surface coating. the surface coating comprising a Metal-Organic Framework (MOF) film wherein: (i) a first surface of the MOF film is bonded to the substrate: (ii) a second surface of the MOF film is an outer surface, functionalized with a plurality of surface functionalization groups; wherein: the MOF film comprises a MOF, the MOF having: metal ions selected from ions of Zr, Al, Fe, Cr and Ti; and multivalent linker groups having a structure according to formula (I): wherein A is a C5-26 aryl group, optionally substituted with one or more groups selected from amino, halo, hydroxyl, nitro, azido, and C2-4 alkynyl and cyclooctynyl; L is a ligation group, each independently selected from carboxyl, hydroxyl and 5- or 6-membered heteroaryl having from 1 to 3 nitrogen heteroatoms; and n is an integer number in the range 2 to 6; the surface functionalization groups are covalently bonded to the second surface of the MOF film and are independently selected from C1-40 alkyl groups optionally substituted with halo; C5-20 carboaryl groups optionally substituted with C1-6 alkyl and/or halo; C5-20 cycloalkyl groups optionally substituted with C1-6 alkyl and/or halo; silyl-C1-40 alkyl groups optionally substituted with halo; and polydimethylsiloxane oligomers having from 5 to 50 repeating units; the MOF film having an average thickness in the range 50-500 nm; and the surface coating having an optical transmission of greater than 75% to light having a wavelength in the range 400-700 nm. Also described are methods of forming such coatings using a layer-by-layer deposition process.
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公开(公告)号：US11947052B2
公开(公告)日：2024-04-02
申请号：US17767665
申请日：2020-10-09
申请人： UCL Business Ltd.
发明人： Simon Jolly , Raffaella Radogna , Laurent Kelleter
CPC分类号： G01T1/023 , G01T1/2914
摘要： Examples of the present disclosure relate to a particle beam dose profile measurement apparatus comprising a particle detector stack comprising a plurality of scintillator layers. Each scintillator layer of the detector stack is disposed along an axis of the apparatus such that the axis projects through each layer. Each scintillator layer is configured to produce scintillation light indicative of an energy deposition, in that scintillator, of a particle beam incident upon the detector stack along said axis. The apparatus comprises readout circuitry configured to measure the scintillation light of each scintillator layer; and dose profile determination circuitry configured to determine a dose profile of said particle beam within the detector stack. Said determining is based on the measured scintillation light of each scintillator layer, and a quenching correction.
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9.发明授权公开(公告)号：US11920200B2
公开(公告)日：2024-03-05
申请号：US16469963
申请日：2017-12-15
发明人： Martin Widschwendter , Allison Jones , Iona Evans , Harri Lempiäinen , Johannes Eichner , Tamas Rujan , Timo Wittenberger , Tobias Paprotka , Benjamin Lindner
IPC分类号： C12Q1/6886 , G16B20/00 , G16B40/10 , G16H20/00 , G16H50/20
CPC分类号： C12Q1/6886 , G16B20/00 , G16B40/10 , G16H20/00 , G16H50/20 , C12Q2600/106 , C12Q2600/112 , C12Q2600/118 , C12Q2600/154
摘要： The present invention relates to methods of determining the presence or absence of certain cancers in a human individual, as well as to related methods to determine the response to therapy against certain cancers in a human individual, in particular ovarian cancer in a woman. Such methods are based on the detection-from (eg cell-free) DNA of said human individual—of one or more methylated (or un-methylated) CpGs being associated with differentially methylated regions (DMRs) of the present invention; such as methylation (or un-methylation) at one or more or all of certain CpGs being associated with such DMRs. Accordingly, such methods have diagnostic, prognostic and/or predictive utility for detecting or managing certain cancers in women or men, in particular ovarian cancer in women. The present invention further relates to nucleic acids comprising certain sequences that may be detected during the method, or nucleic acids (such as probes and/or primers) that are useful to detect such sequences, as wells as compositions, kits, computer program products and other aspects that are useful for or related to the practice or application of such methods.
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10.发明公开公开(公告)号：US20240060136A1
公开(公告)日：2024-02-22
申请号：US18009957
申请日：2021-06-17
申请人： UCL Business Ltd
发明人： Martin Widschwendter , James Barrett , Allison Jones , Iona Evans
IPC分类号： C12Q1/6886 , C12Q1/70 , C12Q1/6837
CPC分类号： C12Q1/6886 , C12Q1/708 , C12Q1/6837 , C12Q2600/154 , C12Q1/6806
摘要： The present invention relates to assays for predicting the presence, absence or development of CIN3 and/or cancer, particularly cervical or endometrial cancer, most preferably cervical cancer, in an individual, particularly cervical and endometrial cancer, by determining the methylation status of certain CpGs in a population of DNA molecules in a sample which has been taken from the individual, deriving an index value based on the methylation status of the certain CpGs, and predicting the presence, absence or development of CIN3 and/or cancer, particularly cervical or endometrial cancer, most preferably cervical cancer, in the individual based on the cancer index value. The invention further relates to a method of treating and/or prevention of cancer in an individual, particularly cervical and endometrial cancer, the method comprising assessing the presence, absence or development of CIN3 and/In or cancer, particularly cervical or endometrial cancer, most preferably cervical cancer, in an individual by performing the assays of the invention, followed by administering one or more therapeutic treatments or measures to the individual based on the assessment. The invention further provides a method of monitoring the CIN3 and/or cancer status of an individual according to changes in the individual's cancer index value over the course of time. The invention further relates to arrays which are suitable for performing the assays of the invention.
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