公开(公告)号：US20200282398A1

公开(公告)日：2020-09-10

申请号：US16758123

申请日：2017-12-22

申请人： UNIST (ULSAN NATIONAL INSTITUTE OF SCIENCE AND TECHNOLOGY) ,  CLINOMICS CO.

发明人： Yoon Kyoung CHO ,  Kyusaog Lee ,  Yongjin Lee

IPC分类号： B01L3/00

摘要： Provided is a microfluidic device to more easily and effectively operate a valve by improving the structure of valves for controlling a fluid flow more simply and efficiently, which comprises a platform having at least one chamber, at least one flow channel connected to the chambers and transfer fluid, and a valve which opens or closes the flow channel, wherein the valve comprises a body installed in the platform, a blocking plate installed in the body and positioned to face the flow channel to selectively blocks the flow channel, a pressing rod installed to be movable at the inside of the body to press the blocking plate, and a fixing unit installed at the body and fix the pressing rod at a blocking plate pressing position.

公开(公告)号：US20180002654A1

公开(公告)日：2018-01-04

申请号：US15536748

申请日：2015-12-18

申请人： UNIST (ULSAN NATIONAL INSTITUTE OF SCIENCE AND TECHNOLOGY)

发明人： Yoon Kyoung CHO ,  Cedric BATHANY ,  Jun Young KIM ,  Devrim GOZUACIK

IPC分类号： C12M1/34 ,  G01N33/48 ,  C12M1/12 ,  C12M3/06 ,  G01N33/543 ,  G01N33/50

CPC分类号： C12M41/46 ,  C12M1/34 ,  C12M23/16 ,  C12M25/02 ,  G01N33/48 ,  G01N33/5005 ,  G01N33/54366

摘要： A device for single-cell analysis according to an embodiment of the present invention comprises: a substrate; a gap between the substrate and porous membrane which is a space for culture medium; and a porous membrane formed on having a pore capable of isolating a second cell into single cell units.A method for single-cell analysis according to an embodiment of the present invention comprises: Culturing a first cell in a culture medium on a bottom side of porous membrane; Applying a sample including a second cell on a porous membrane in a culture medium; Isolating the second cell into single cell units in a pore existing in the porous membrane with a external force such as agitation and gravitational force; Generating an interaction situation between the first cells and the single cell-level second cell; Analyzing a cellular phenomena of the first cell or the second cell.

公开(公告)号：US20180312902A1

公开(公告)日：2018-11-01

申请号：US15770238

申请日：2016-10-21

申请人： UNIST(ULSAN NATIONAL INSTITUTE OF SCIENCE AND TECHNOLOGY)

发明人： Yoon Kyoung CHO ,  Chi Ju KIM ,  Tae Hyeong KIM

IPC分类号： C12Q1/6806

CPC分类号： B01L3/00 ,  C12N15/10 ,  C12Q1/68 ,  G01N35/00 ,  G01N35/08

摘要： Provided is a nucleic acid purification device which is rotatably installed such that the entire processes of purifying a cell-free nucleic acid from a large amount of blood and a large amount of body fluid are integrated, the nucleic acid purification device including a disk in which a fluid is transferred by a centrifugal force, a supply portion installed in the disk and configured to supply a specimen and a reagent required for nucleic acid purification, an adsorption reaction chamber which is installed in the disk and is connected with the supply portion and in which an adsorption medium for adsorbing a nucleic acid is accommodated and the nucleic acid is adsorbed from the specimen, and a solution accommodating portion which is connected with an output side of an adsorption reaction portion along a centrifugal direction of the disk and in which a solution discharged through the adsorption reaction chamber by the centrifugal force is accommodated and is discharged to the outside.