专利检索 ap:("UNIVERSIDADE DO PORTO") AND inv:"Vítor Manuel DE OLIVEIRA E VASCONCELOS" 第 1 页

1.

发明申请
PYRAZINOQUINAZOLINONE DERIVATIVES WITH ANTIBACTERIAL ACTIVITY, METHODS AND USES THEREOF 审中-公开

公开(公告)号：US20180185370A1

公开(公告)日：2018-07-05

申请号：US15739353

申请日：2016-06-23

申请人： UNIVERSIDADE DO PORTO

发明人： Vítor Manuel DE OLIVEIRA E VASCONCELOS , Lucinda Janete DA SILVA BESSA , Anake KIJJOA , Suradet BUTTACHON , Tida DETHOUP , Paulo Manuel RODRIGUES MARTINS DA COSTA

IPC分类号： A61K31/519 , A61K31/43 , C07D519/00 , A61P31/04 , A61K31/431 , A61K45/06

CPC分类号： A61K31/519 , A61K31/43 , A61K31/431 , A61K31/527 , A61K45/06 , A61P31/04 , C07D519/00 , A61K2300/00

摘要： The present disclosure relates to compounds and compositions displaying antibacterial activity, particularly against Gram-positive bacteria. The compounds comprise a class of pyrazinoquinazolinone derivatives, including neofiscalin A and fiscalin C, or pharmaceutically acceptable salts, esters, solvates or prodrugs thereof. The present disclosure further relates to methods for treating a patient with a bacterial infection with the disclosed compounds and compositions.