公开(公告)号：US20180185370A1

公开(公告)日：2018-07-05

申请号：US15739353

申请日：2016-06-23

申请人： UNIVERSIDADE DO PORTO

发明人： Vítor Manuel DE OLIVEIRA E VASCONCELOS ,  Lucinda Janete DA SILVA BESSA ,  Anake KIJJOA ,  Suradet BUTTACHON ,  Tida DETHOUP ,  Paulo Manuel RODRIGUES MARTINS DA COSTA

IPC分类号： A61K31/519 ,  A61K31/43 ,  C07D519/00 ,  A61P31/04 ,  A61K31/431 ,  A61K45/06

CPC分类号： A61K31/519 ,  A61K31/43 ,  A61K31/431 ,  A61K31/527 ,  A61K45/06 ,  A61P31/04 ,  C07D519/00 ,  A61K2300/00

摘要： The present disclosure relates to compounds and compositions displaying antibacterial activity, particularly against Gram-positive bacteria. The compounds comprise a class of pyrazinoquinazolinone derivatives, including neofiscalin A and fiscalin C, or pharmaceutically acceptable salts, esters, solvates or prodrugs thereof. The present disclosure further relates to methods for treating a patient with a bacterial infection with the disclosed compounds and compositions.

公开(公告)号：US20220274987A1

公开(公告)日：2022-09-01

申请号：US17632648

申请日：2020-08-20

申请人： CIIMAR -CENTRO INTERDISCIPLINAR DE INVESTIGAÇÃO MARINHA E AMBIENTAL ,  UNIVERSIDADE DO PORTO ,  Universidade Nova De Lisboa

发明人： Maria Emilia DA SILVA PEREIRA DE SOUSA ,  Solida LONG ,  Madalena Maria DE MAGALHAES PINTO ,  Diana RESENDE ,  Anake KIJJOA ,  Paulo Manuel RODRIGUES MARTINS DA COSTA ,  Joana Manuela MACHADO FREITAS DA SILVA ,  Fatima NOGUEIRA

IPC分类号： C07D471/14 ,  C07D487/04 ,  A61K45/06

摘要： The present disclosure relates to pyrazino [1,2-b]quinazoline-3,6-diones compounds, in particular it relates to pyrazino [1,2-b]quinazoline-3,6-diones compounds having antibacterial activity and/or antimalarial activity.