公开(公告)号：US20250057951A1

公开(公告)日：2025-02-20

申请号：US18719780

申请日：2022-12-16

Applicant: UNIVERSITÄT BASEL ,  CIMEIO THERAPEUTICS AG

Inventor： Stefanie URLINGER ,  Rosalba LEPORE ,  Lukas JEKER ,  Amélie WIEDERKEHR ,  Alessandro SINOPOLI ,  Anna CAMUS ,  Lisa WELLINGER ,  Romina MATTER-MARONE

IPC: A61K39/00

Abstract: The present disclosure relates to the use of cells having discernible surface protein with engineered or naturally occurring mutation(s) but functional surface protein for use in therapy. The present invention also relates to the use of cells having discernible CD117 surface protein variants but functional surface protein for use in therapy, in particular adoptive cell therapy.