公开(公告)号：US20220380411A1

公开(公告)日：2022-12-01

申请号：US17769689

申请日：2020-10-20

Applicant: UNIVERSITÄT ULM

Inventor： Stefan KOCHANEK ,  Lea KRUTZKE ,  Robin STEINER ,  Olivia LÜBBERS

IPC: C07K14/005 ,  C12N15/86 ,  A61K35/28

Abstract: The invention discloses a human adenovirus species C having a capsid which comprises a modified adenovirus hexon protein, wherein the modified adenovirus hexon protein has a modified HVR1 region, wherein the modified HVR1 region has the sequence DEAATALEINLKKKKQAEQQ (SEQ ID NO.: 1). The invention further discloses the adenovirus of the disclosure for use in treating or preventing a human disease. The invention further discloses a nucleic acid encoding the modified adenovirus hexon protein. The invention further discloses the use of an adenovirus according to the disclosure for transducing mesenchymal stromal cells (MSCs) or tumor cells. The invention further discloses an in vitro method for transducing MSCs and a transduced MSC obtainable by the method. The invention further discloses the transduced MSC of the disclosure for use in treating a disease.