公开(公告)号：US20180265528A1

公开(公告)日：2018-09-20

申请号：US15761350

申请日：2016-09-23

申请人： UNIVERSITÉ DE BRETAGNE OCCIDENTALE ,  INSERM (INSTITUT NATIONAL DE LA SANTÉ ET DE LA RECERCHE MÉDICALE ,  CENTER HOSPITALIER RÉGIONAL ET UNIVERSITAIRE DE BREST

发明人： Paul-Alain JAFFRÈS ,  Hélène COUTHON-COURVÈS ,  Damien AFONSO ,  Tristan MONTIER ,  Tony LE GALL

IPC分类号： C07F9/24 ,  C07C217/28 ,  C12N15/88

摘要： Disclosed are novel branched amphiphilic lipids, in particular novel branched amphiphilic lipids of general formula (II). Also disclosed is a method of synthesis for the compounds of formula (II), from unsaturated amphiphilic compounds of general formula (I). Further disclosed is the use of the compounds of general formula (II) and of the lipoplexes obtained by formulation of the compounds of general formula (II) for applications, particularly transfection, in which improved fusion properties are desired.