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公开(公告)号：US20230063059A1
公开(公告)日：2023-03-02
申请号：US17442640
申请日：2020-03-23
申请人： UNIVERSITÉ DE BRETAGNE OCCIDENTALE - UBO , CENTRE HOSPITALIER RÉGIONAL ET UNIVERSITAIRE DE BREST , INSERM-INSTITUT NATIONAL DE LA SANTÉ ET DE LA RECHERCHE MÉDICALE
发明人： OLIVIER MIGNEN , PAUL BUSCAGLIA , PATRICE HEMON , NELIG LE GOUX
IPC分类号： C07K16/30 , G01N33/574 , G01N33/50 , A61K31/7068 , A61P35/00 , A61P1/18 , A61K39/395
摘要： The present invention relates to a substance interacting with C terminal fragment of the STIM1 fraction localized to the plasma membrane of the cells, for its use in the treatment of cancers. The present invention further relates to a pharmaceutical composition comprising at least one substance interacting with C terminal fragment of the STIM1 fraction localized to the plasma membrane of cells, and at least one pharmaceutically acceptable excipient. The invention also refers to the use of isolated C terminal fragment of the STIM1 fraction localized to the plasma membrane of cells in a method for screening candidate molecules for treating cancers, especially pancreatic, colon, breast, Burkitt lymphoma or chronic Lymphocytic Leukaemia. The present invention also relates to a process for predicting the progression and/or monitoring the progression of a cancer, comprising the in vitro detection of the expression of STIM1 in a sample of the tumour of the subject.
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公开(公告)号：US11458118B2
公开(公告)日：2022-10-04
申请号：US16606236
申请日：2018-04-20
申请人： INSERM (INSTITUT NATIONAL DE LA SANTÉ ET DE LA RECHERCHE MÉDICALE) , UNIVERSITÉ DE BRETAGNE OCCIDENTALE , ETABLISSEMENT FRANÇAIS DU SANG (EFS) , CENTRE HOSPITALIER REGIONAL ET UNIVERSITAIRE DE BREST
IPC分类号： A61K31/40 , A61P11/00 , A61K9/00 , C12N15/113
摘要： Activating transcription factor 6 (ATF6) is involved in cystic fibrosis transmembrane conductance regulator (CFTR) repression and understanding this inhibitory mechanism is of great interest to develop a therapeutic approach based on UPR regulation. Using site-1 protease (S1P) inhibitor (e.g. PF-429242) the inventors showed that both membrane localization and function of F508del-CFTR are partially restored. Accordingly, the present invention relates to a method of treating a disease associated with reduced CFTR function in a subject in need thereof comprising administering to the subject a therapeutically effective amount of a S1P inhibitor.
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公开(公告)号：US20210017180A1
公开(公告)日：2021-01-21
申请号：US17042408
申请日：2019-03-29
申请人： CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE , ÉCOLE NORMALE SUPÉRIEURE DE LYON , UNIVERSITÉ CLAUDE BERNARD LYON 1 (UCBL1) , UNIVERSITÉ DE BRETAGNE OCCIDENTALE
发明人： Nadège HAMON , Maryline BEYLER , Raphaël TRIPIER , Olivier MAURY , Janah SHAYA
IPC分类号： C07D471/08 , A61K49/00
摘要： A ligand of Formula (A): or a carboxylate salt thereof; wherein Y1, Y2 and Y3 each independently represents —COOH or a picolinate of Formula (i): wherein each R1 independently represents a chromophore group; L1, L2 and L3 each independently represents a single bond or a linker; and X1, X2 and X3 each independently represents a hydrogen atom, a coupling function or a bio-vectorizing group. Also, a process for manufacturing the ligand and to a process for manufacturing a chelate by complexation by the ligand of a rare-earth cation, preferably a lanthanide cation. Further, a use of the ligand and/or the chelate in biological imaging and/or photoluminescence imaging.
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公开(公告)号：US20200150105A1
公开(公告)日：2020-05-14
申请号：US16629362
申请日：2018-07-09
摘要： The present invention relates to a novel analysis device and method for obtaining the concentration of dissolved inorganic carbon (DIC) and isotopic carbon and oxygen concentration thereof, continuously from a liquid sample.
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公开(公告)号：US20180267035A1
公开(公告)日：2018-09-20
申请号：US15554166
申请日：2016-02-26
申请人： UNIVERSITÉ DE BRETAGNE OCCIDENTALE - UBO , INSERM , CENTRE HOSPITALIER RÉGIONAL ET UNIVERSITAIRE DE BREST
发明人： Yves RENAUDINEAU , Olivier MIGNEN , Marjolaine DEBANT , Christelle LE DANTEC , Jacques Olivier PERS
IPC分类号： G01N33/564 , G01N33/574
CPC分类号： G01N33/564 , G01N33/57426 , G01N33/6893 , G01N2800/104 , G01N2800/52 , G01N2800/7028
摘要： Some embodiments are directed to a process for the diagnosis of systemic lupus erythematosus (SLE) and/or of chronic lymphoid leukaemia (CLL) of a subject who may be suffering therefrom, comprising the in vitro detection of the expression of the fraction of the STIM1 protein located at the cell plasma membrane in a biological sample from human and mice. Some other embodiments are directed to a process for predicting the progression and/or monitoring the progression of CLL and/or of SLE, comprising the in vitro detection of the expression of the fraction of the STIM1 protein located at the cell plasma membrane.
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公开(公告)号：US20180265528A1
公开(公告)日：2018-09-20
申请号：US15761350
申请日：2016-09-23
申请人： UNIVERSITÉ DE BRETAGNE OCCIDENTALE , INSERM (INSTITUT NATIONAL DE LA SANTÉ ET DE LA RECERCHE MÉDICALE , CENTER HOSPITALIER RÉGIONAL ET UNIVERSITAIRE DE BREST
IPC分类号： C07F9/24 , C07C217/28 , C12N15/88
摘要： Disclosed are novel branched amphiphilic lipids, in particular novel branched amphiphilic lipids of general formula (II). Also disclosed is a method of synthesis for the compounds of formula (II), from unsaturated amphiphilic compounds of general formula (I). Further disclosed is the use of the compounds of general formula (II) and of the lipoplexes obtained by formulation of the compounds of general formula (II) for applications, particularly transfection, in which improved fusion properties are desired.
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公开(公告)号：US20240008951A1
公开(公告)日：2024-01-11
申请号：US18253316
申请日：2021-11-17
申请人： CENTRE HOSPITALIER RÉGIONAL ET UNIVERSITAIRE DE BREST , UNIVERSITÉ DE BRETAGNE OCCIDENTALE , INSERM (INSTITUT NATIONAL DE LA SANTÉ ET DE LA RECHERCHE MÉDICALE)
发明人： Guillaume DARDENNE , Hoel LETISSIER , Jérôme OGOR , Eric STINDEL
CPC分类号： A61B90/39 , A61B34/10 , A61B2034/105 , A61B2090/3937
摘要： A computer-implemented method and a system for providing anatomical landmarks of a subject's body part using a set of measures previously acquired by an ultrasound device including at least one fiducial marker and an imaging sensor. Also, a non-transitory computer readable medium including instructions which, when the program is executed by a computer, cause the computer to carry out the method.
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公开(公告)号：US11740220B2
公开(公告)日：2023-08-29
申请号：US16629362
申请日：2018-07-09
CPC分类号： G01N33/1846 , B01D19/0005 , B01D19/0036 , G01N35/1097
摘要： The present invention relates to a novel analysis device and method for obtaining the concentration of dissolved inorganic carbon (DIC) and isotopic carbon and oxygen concentration thereof, continuously from a liquid sample.
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公开(公告)号：US20230058212A1
公开(公告)日：2023-02-23
申请号：US17442638
申请日：2020-03-23
申请人： UNIVERSITÉ DE BRETAGNE OCCIDENTALE - UBO , CENTRE HOSPITALIER RÉGIONAL ET UNIVERSITAIRE DE BREST , INSERM -INSTITUT NATIONAL DE LA SANTÉ ET DE LA RECHERCHE MÉDICALE
摘要： The present invention relates to a compound that specifically binds to the region between amino acid residues 58 and 201, preferably 97 and 127 of human STIM1 (SEQ ID NO: 1). The present invention also relates to a composition comprising a therapeutically effective amount of the compound, a host cell that produces an isolated antibody, an isolated nucleic acid sequence encoding the isolated antibody and an expression vector comprising the nucleic acid. The present invention additionally relates to a method of producing the isolated antibody, to the isolated antibody for its use as a drug, especially for its use in treating a condition or a disorder in which the STIM1 protein localized to the plasma membrane of the cells is overexpressed, and to an isolated protein fragment consisting of the region between amino acid residues 97 and 127 for developing modulators of STIM1 (SEQ ID NO: 1).
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公开(公告)号：US20230055411A1
公开(公告)日：2023-02-23
申请号：US17442636
申请日：2020-03-23
申请人： UNIVERSITÉ DE BRETAGNE OCCIDENTALE - UBO , CENTRE HOSPITALIER RÉGIONAL ET UNIVERSITAIRE DE BREST , INSERM -INSTITUT NATIONAL DE LA SANTÉ ET DE LA RECHERCHE MÉDICALE
摘要： The present invention relates to a compound that specifically binds to the region between amino acid residues 58 and 201 of human STIM1 (SEQ ID NO: 1). The present invention also relates to a composition comprising a therapeutically effective amount of the compound, a host cell that produces an isolated antibody, an isolated nucleic acid sequence encoding the isolated antibody and an expression vector comprising the nucleic acid. The present invention additionally relates to a method of producing the isolated antibody, to the isolated antibody for its use as a drug, especially for its use in treating a condition or a disorder in which the STIM1 protein localized to the plasma membrane of the cells is overexpressed, and to an isolated protein fragment consisting of the region between amino acid residues 58 and 201 for developing modulators of the STIM1 amino acid sequence SEQ ID NO: 1.
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