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    Compositions and methods for treatment of central nervous system tumors
    3.
    发明授权
    Compositions and methods for treatment of central nervous system tumors 有权

    公开(公告)号：US11434195B2

    公开(公告)日：2022-09-06

    申请号：US16632721

    申请日：2018-07-20

    申请人： UNIVERSITY OF FLORIDA RESEARCH FOUNDATION, INC.

    发明人： Stanislav Igorevich Svetlov

    IPC分类号： C07C217/28 ,  A61K31/133

    摘要： Compounds, pharmaceutical compositions, and methods for treating cancer, in particular brain cancer, are provided, including amphiphilic fatty acid/alcohol ethers (AIPs) comprising endocannabinoid and FABP motifs covalently linked to a beta-adrenoreceptor antagonist motif in one molecule. The invention includes methods for inhibiting growth of brain cancer cells by contacting the compound(s) with brain cancer cells. The invention provides a method for treating both brain cancer and brain cancer metastases, and for suppression of regrowth of brain cancer cells after radiation, surgical treatment, or chemotherapy of brain cancer. The invention also comprises an optimized chemical synthesis of the AIP compounds and methods of using the compounds, alone or in combination with another agent, for suppressing the growth of brain cancer cells, and enhancing survival of normal CNS cells, or improving recuperation from radiation, surgical or chemotherapy.

    Removal of hydrogen sulphide and carbon dioxide from a stream of fluid
    7.
    发明授权
    Removal of hydrogen sulphide and carbon dioxide from a stream of fluid 有权

    公开(公告)号：US10207217B2

    公开(公告)日：2019-02-19

    申请号：US15506635

    申请日：2015-08-20

    申请人： BASF SE

    发明人： Thomas Ingram ,  Ralf Notz ,  Gerald Vorberg ,  Georg Sieder

    IPC分类号： B01D53/14 ,  B01D53/52 ,  B01D53/78 ,  B01D53/96 ,  C07C217/08 ,  C07C217/28 ,  C07C217/42

    摘要： A process for removing hydrogen sulfide and carbon dioxide from a fluid stream comprises a) an absorption step in which the fluid stream is contacted with an absorbent comprising an aqueous solution (i) of an amine of the general formula (I) in which R1, R2 and R3 are each independently selected from C1-4-alkyl and C1-4-hydroxyalkyl; each R4 is independently selected from hydrogen, C1-4-alkyl and C1-4-hydroxyalkyl; each R5 is independently selected from hydrogen, C1-4-alkyl and C1-4-hydroxyalkyl; X is OH or NH(CR1R2R3); m is 2, 3, 4 or 5; n is 2, 3, 4 or 5; and o is 0 or 1; and optionally (ii) at least one tertiary amine, where the molar ratio of (i) to (ii) is greater than 0.05; wherein at least 90% of the hydrogen sulfide is removed from the fluid stream and selectivity for hydrogen sulfide over carbon dioxide is not greater than 8, wherein a CO2- and H2S-laden absorbent is obtained; b) a regeneration step in which at least a substream of the CO2- and H2S-laden absorbent is regenerated and a regenerated absorbent is obtained; and c) a recycling step in which at least a substream of the regenerated absorbent is recycled into the absorption step a). The process allows a high level of hydrogen sulfide removal with a simultaneously high coabsorption of carbon dioxide.