公开(公告)号：US20150307471A1

公开(公告)日：2015-10-29

申请号：US14653669

申请日：2013-12-20

申请人： UNIVERSITE DE DROIT ET DE LA SANTE DE LILLE 2

发明人： Nicolas Willand ,  Benoit Deprez ,  Alain Baulard ,  Priscille BRODIN ,  Marion FLIPO

IPC分类号： C07D401/04 ,  A61K31/451 ,  C07D295/185 ,  A61K31/495 ,  A61K45/06 ,  C07D211/22 ,  A61K31/4545 ,  C07D207/08 ,  A61K31/40 ,  C07D211/16 ,  C07D211/18

CPC分类号： C07D401/04 ,  A61K31/40 ,  A61K31/451 ,  A61K31/4545 ,  A61K31/495 ,  A61K45/06 ,  C07D207/08 ,  C07D211/16 ,  C07D211/18 ,  C07D211/22 ,  C07D295/185

摘要： The present invention concerns a compound of general formula (I): in which n=0 or 1, R1 represents an optionally substituted alkyl chain, in particular substituted alkyl chain, in particular substituted with fluorine, X is chosen from N and CH, and R2 is chosen from optionally substituted phenyl and benzyl, wherein the heterocycles having 6 vertices comprise one, two or three nitrogen atoms. The present invention also concerns the use of this compound as a medicament, in particular in the treatment of bacterial and mycobacterial infections such as tuberculosis in combination with an antibiotic that is active against bacteria and/or mycobacteria, said compound potentiating the activity of said antibiotic.

摘要翻译： 本发明涉及通式（I）的化合物：其中n = 0或1，R 1表示任选取代的烷基链，特别是取代的烷基链，特别是被氟取代，X选自N和CH，和 R2选自任选取代的苯基和苄基，其中具有6个顶点的杂环包含一个，两个或三个氮原子。 本发明还涉及这种化合物作为药物的用途，特别是在治疗细菌和分枝杆菌感染如结核病与抗细菌和/或分枝杆菌活性的抗生素的组合中，所述化合物增强所述抗生素的活性 。