公开(公告)号：US20170080112A1

公开(公告)日：2017-03-23

申请号：US15126523

申请日：2015-03-18

申请人： UNIVERSITE DE NANTES ,  CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (CNRS)

发明人： Elena ISHOW ,  Adrien FAUCON

IPC分类号： A61K49/18 ,  A61K49/00 ,  A61K31/7048 ,  A61K41/00 ,  A61K49/12 ,  A61K49/10

CPC分类号： A61K49/1878 ,  A61K31/7048 ,  A61K41/0042 ,  A61K47/6923 ,  A61K47/6929 ,  A61K49/0002 ,  A61K49/0021 ,  A61K49/0054 ,  A61K49/0093 ,  A61K49/10

摘要： Disclosed are magnetic and fluorescent nanoassemblies having reverse architectures. Especially, the nanoassemblies include an organic fluorescent inner core and magnetic nanoparticles contacting the surface of the fluorescent core. The nanoassemblies may further be coated by a polymer adsorbed at its surface, the polymer being optionally functionalized. Also described is a process for manufacturing the nanoassemblies, as well as use of the nanoassemblies, especially for multimodal imaging; in vitro and/or in vivo diagnostics through multimodal imaging; ex vivo sensing and/or extraction; and/or therapy.

公开(公告)号：US20150265728A1

公开(公告)日：2015-09-24

申请号：US14218368

申请日：2014-03-18

申请人： CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (CNRS) ,  UNIVERSITE DE NANTES

发明人： Elena ISHOW ,  Adrien FAUCON

IPC分类号： A61K49/18 ,  A61K47/48 ,  A61K41/00 ,  A61K49/12

CPC分类号： A61K49/1878 ,  A61K31/7048 ,  A61K41/0042 ,  A61K47/52 ,  A61K47/545 ,  A61K47/557 ,  A61K47/6929 ,  A61K47/6937 ,  A61K49/0002 ,  A61K49/0021 ,  A61K49/0054 ,  A61K49/0093 ,  A61K49/10

摘要： The present invention relates to magnetic and fluorescent nanoassemblies having reverse architectures. Especially, the nanoassemblies of the invention comprise a fluorescent core and magnetic nanoparticles contacting the surface of the fluorescent core. The nanoassemblies of the invention may further be coated by a polymer, which may optionally be functionalized. The invention further relates to a process for manufacturing the nanoassemblies of the invention. The invention is also directed to the use of the nanoassemblies of the invention, especially for multimodal imaging, in vitro and/or in vivo diagnostics through multimodal imaging, and/or therapy.

摘要翻译： 本发明涉及具有反向架构的磁性和荧光纳米组件。 特别地，本发明的纳米组件包括与荧光芯的表面接触的荧光芯和磁性纳米颗粒。 本发明的纳米组件还可以通过聚合物进行涂覆，聚合物可任选地被官能化。 本发明还涉及制造本发明的纳米组件的方法。 本发明还涉及本发明的纳米组件，特别是多模式成像，通过多模式成像和/或治疗的体外和/或体内诊断的用途。