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公开(公告)号：US12299908B2
公开(公告)日：2025-05-13
申请号：US17423597
申请日：2020-01-17
Applicant: University Health Network
Inventor： Ralph S. Dacosta , Kathryn Ottolino-Perry , Christopher Gibson
Abstract: The present disclosure provides methods, systems, and devices for coregistering imaging data to form three-dimensional superimposed images of target such as a tumor or a surgical bed. A three-dimensional map can be generated by projecting infrared radiation at a target area, receiving reflected infrared radiation, and measuring depth of the target area. A three-dimensional white light image can be created from a captured two-dimensional white light image and the three-dimensional map. A three-dimensional fluorescence image can be created from a captured two-dimensional fluorescence image and the three-dimensional map. The three-dimensional white light image and the three-dimensional fluorescence image can be aligned using one or more fiducial markers to form a three-dimensional superimposed image. The superimposed image can be used to excise cancerous tissues, for example, breast tumors. Images can be in the form of videos.
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公开(公告)号：US20210378518A1
公开(公告)日：2021-12-09
申请号：US17408027
申请日：2021-08-20
Applicant: UNIVERSITY HEALTH NETWORK
Inventor： Ralph S. Dacosta , Brian C. Wilson , Kai Zhang
Abstract: A method for fluorescence-based imaging of a target to detect contamination and/or pollutants is disclosed. The method includes labelling a pre-selected biomarker at the target, illuminating the target with excitation light emitted by an excitation light source and having at least one wavelength or wavelength band causing at least the pre-selected biomarker to fluoresce, detecting fluorescence emissions of at least the pre-selected biomarker with an image detector of a handheld imaging device, and determining the presence, location, and/or quantity of contamination and/or pollutants on and/or in the illuminated target based on the detected fluorescence emissions of at least the pre-selected biomarker.
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公开(公告)号：US11154198B2
公开(公告)日：2021-10-26
申请号：US16027775
申请日：2018-07-05
Applicant: UNIVERSITY HEALTH NETWORK
Inventor： Ralph S. Dacosta , Brian C. Wilson , Kai Zhang
Abstract: A system for fluorescence-based imaging of a target includes at least one excitation light source configured to emit a homogeneous field of excitation light and positioned to uniformly illuminate a target surface with the homogeneous field of excitation light during fluorescent imaging, a power source, and a portable housing configured to be held in a user's hand during imaging. The housing contains a lens, a filter, an image sensor, and a processor. The filter is configured to permit optical signals responsive to illumination of the target surface and having a wavelength corresponding to at least one of bacterial autofluorescence and tissue autofluorescence to pass through the filter to the image sensor. The at least one excitation light is adjacent to the housing so as to be positioned between the target surface and the image sensor during fluorescent imaging.
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