公开(公告)号：US20190338445A1

公开(公告)日：2019-11-07

申请号：US16508620

申请日：2019-07-11

申请人： University of Central Oklahoma

发明人： Maurice Haff ,  Morshed KHANDAKER ,  William Paul SNOW

IPC分类号： D01D5/00 ,  D04H1/728 ,  D01D5/34

摘要： An apparatus for collecting cross-aligned fiber threads, comprising an elongated assembly having a plurality of segments including at least a first segment, a second segment, and an intermediate segment, the first segment positioned at one end of the intermediate segment and the second segment positioned at an opposite end of the intermediate segment, each segment being electrically chargeable; an electrically chargeable emitter for electrospinning nanoscale fiber streams comprising charged fiber branches, the emitter having a tip positioned offset and between an edge of the first segment and an edge of the second segment; a support structure for rotating the elongated assembly about a longitudinal axis and applying an electrical charge to at least the edges of the first and second segment; at least one electrically chargeable steering electrode for attracting fiber streams, the at least one steering electrode chargeable with an electrical polarity opposing a charge applied to the emitter.

公开(公告)号：US20160047064A1

公开(公告)日：2016-02-18

申请号：US14734147

申请日：2015-06-09

申请人： UNIVERSITY OF CENTRAL OKLAHOMA

发明人： Morshed KHANDAKER ,  William Paul SNOW

IPC分类号： D01D5/00 ,  A61C13/00

CPC分类号： D01D5/0084 ,  A61C13/0006 ,  A61F2240/001 ,  D01D5/0076

摘要： A method for separating out a continuous single thread of fiber from many fiber branches and controlling alignment and deposition of said fiber on a substrate, comprising: electrospinning synthetic polymer fiber streams from an electrically charged syringe needle; controlling the fiber using at least one electrically charged metallic disk rotating about an axis positioned below the needle; capturing the fiber using electrically grounded collector; extracting a single fiber branch thread from the polymer fiber streams, wherein the single fiber branch thread is attracted to and intercepted by the collector shape, and depositing the single fiber branch thread as substantially aligned fiber on the collector.

摘要翻译： 一种用于从许多纤维分支中分离纤维的连续单线并控制所述纤维在衬底上的对准和沉积的方法，包括：从带电的注射器针静电纺合成聚合物纤维流; 使用至少一个带电的金属盘控制所述纤维，所述至少一个带电的金属盘围绕位于所述针的下方的轴线旋转; 使用电接地收集器捕获光纤; 从聚合物纤维流中提取单根纤维分支线，其中单根纤维分支线被集电器形状吸引和截取，并将单根纤维分支线作为基本对准的纤维沉积在收集器上。

公开(公告)号：US20160047063A1

公开(公告)日：2016-02-18

申请号：US14825493

申请日：2015-08-13

申请人： UNIVERSITY OF CENTRAL OKLAHOMA

发明人： Morshed KHANDAKER ,  William Paul SNOW

IPC分类号： D01D5/00

CPC分类号： D01D5/0076 ,  D01D5/0069 ,  D01D5/0084 ,  D01D5/0092

摘要： A method for separating out nano-scale fiber threads from many fiber branches and controlling alignment and deposition of the fiber threads on a substrate, comprising: electrospinning at least synthetic polymer fiber streams from an electrically charged syringe needle; controlling the fiber using at least one electrically charged metallic disk rotating about an axis positioned below the needle; capturing the fiber using electrically grounded collector; extracting a single or plurality of fiber branch threads from the fiber streams, wherein the single or plurality of fiber branch threads is attracted to and intercepted by the collector shape, and depositing the single or plurality of fiber branch threads as substantially aligned fiber on the collector.

摘要翻译： 一种用于从许多纤维分支中分离出纳米级纤维丝并控制纤维线在衬底上的对准和沉积的方法，包括：从带电的注射针中至少合成聚合物纤维流; 使用至少一个带电的金属盘控制所述纤维，所述至少一个带电的金属盘围绕位于所述针的下方的轴线旋转; 使用电接地收集器捕获光纤; 从纤维流中提取单个或多个纤维分支线，其中所述单个或多个纤维分支线被所述收集器形状吸引并被所述收集器形状截取，以及将所述单个或多个纤维分支线作为基本对齐的纤维沉积在所述收集器 。

公开(公告)号：US20190142593A1

公开(公告)日：2019-05-16

申请号：US16248122

申请日：2019-01-15

申请人： UNIVERSITY OF CENTRAL OKLAHOMA

发明人： Morshed KHANDAKER ,  Shahram RIAHINEZHAD ,  William Paul SNOW

IPC分类号： A61F2/28 ,  D01D5/00 ,  D01F1/10 ,  D01F6/62 ,  A61F2/30

摘要： The present invention provides a process to functionalize nanofiber membrane (NFM) on a total joint replacement (TJR) implant surface to support bone ingrowth and reduce macrophage-associated inflammation, the process comprising amending the implant surface by laser cutting microgrooves greater than 100 μm in depth to protect functional PCL NFM from applied loading, induce a higher amount of osteoblast cell function, increase implant-bone contact area, and serve as a reservoir for the local delivery of biomolecules to increase osseointegration of the implant; depositing aligned fibers on the implant surface, the fibers aligned in the direction of the microgrooves and collected in layers until a thickness less than 30 μm is reached and preferably in the range of 1 μm to 10 μm. Biofunctionalized NFM are used to indirectly attach biomolecules on said implant surface, or extracellular matrix proteins with biomolecules are immobilized and deposited on the PCL NFM coated implant.