公开(公告)号：US12042369B2

公开(公告)日：2024-07-23

申请号：US16565189

申请日：2019-09-09

申请人： Biostage, Inc.

发明人： Ron Sostek ,  David Green ,  Linghui Meng ,  Sherif Soliman ,  Joseph Consiglio

IPC分类号： A61F2/02 ,  A61F2/00 ,  A61F2/04 ,  A61F2/06 ,  A61F2/07 ,  A61L27/34 ,  A61L27/48 ,  A61L27/56 ,  D01D5/00 ,  D04H1/4382

CPC分类号： A61F2/0063 ,  A61F2/02 ,  A61F2/04 ,  A61F2/07 ,  A61L27/34 ,  D01D5/0007 ,  D01D5/0084 ,  D04H1/43835 ,  D04H1/43838 ,  A61F2002/072 ,  A61F2210/00 ,  A61F2210/0071 ,  A61F2210/0076 ,  A61F2230/0069 ,  A61F2230/0091 ,  A61F2240/001 ,  A61F2250/0082

摘要： Aspects of the disclosure relate to synthetic tissue or organ scaffolds and methods and compositions for promoting or maintaining their structural integrity. Aspects of the disclosure are useful to prevent scaffold damage (e.g., delamination) during or after implantation into a host. Aspects of the disclosure are useful to stabilize tissue or organ scaffolds that include electrospun fibers.

公开(公告)号：US20230363897A1

公开(公告)日：2023-11-16

申请号：US17849565

申请日：2022-06-24

申请人： THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK

发明人： David KALFA

IPC分类号： A61F2/24 ,  D01F6/62 ,  D01F6/70 ,  D01D5/00 ,  B33Y80/00

CPC分类号： A61F2/2418 ,  A61F2/2436 ,  A61F2/2415 ,  D01F6/625 ,  D01F6/70 ,  D01D5/003 ,  B33Y80/00 ,  D01D5/0084 ,  A61F2250/0082 ,  D10B2331/10 ,  D10B2331/041 ,  D10B2509/00 ,  D10B2401/12

摘要： A heart valve replacement is provided including a tubular body portion having a proximal end, a distal end and a central portion arranged between said proximal and distal ends, defining a longitudinal direction of the valve replacement and having an inner wall region; a valve having at least one leaflet attached to the inner wall region of the central portion, each one of said leaflets being movable between a closing position and an opening position of the valve, wherein the tubular body portion is fabricated from a combination of a biostable polymer and a biodegradable biomaterial adapted to allow in-growth of tissue of the host and to increase its size concomitantly with surrounding organ structures of a host, and wherein the valve is fabricated of a biostable polymer connected to the biostable polymer of the tubular body portion.

公开(公告)号：US20230157804A1

公开(公告)日：2023-05-25

申请号：US18151885

申请日：2023-01-09

申请人： Merit Medical Systems, Inc.

发明人： Zeke Eller ,  John William Hall ,  Robert S. Kellar ,  Rachel Lynn Simmons ,  Robert J. Radford ,  Bart Dolmatch

IPC分类号： A61F2/06 ,  D01D5/00 ,  B32B27/32 ,  A61F2/07 ,  A61F2/88 ,  A61L31/10 ,  A61L31/14 ,  A61F2/82

CPC分类号： A61F2/06 ,  A61F2/07 ,  A61F2/82 ,  A61F2/88 ,  A61L31/10 ,  A61L31/146 ,  B32B27/322 ,  D01D5/003 ,  D01D5/0007 ,  D01D5/0038 ,  D01D5/0046 ,  D01D5/0084 ,  A61F2/89 ,  A61F2002/072

摘要： A stent or other prosthesis may be formed by coating a single continuous wire scaffold with a polymer coating. The polymer coating may consist of layers of electrospun polytetrafluoroethylene (PTFE). Electrospun PTFE of certain porosities may permit endothelial cell growth within the prosthesis.

公开(公告)号：US20180347427A1

公开(公告)日：2018-12-06

申请号：US15778702

申请日：2016-11-17

申请人： AMOGREENTECH CO., LTD.

发明人： Chan KIM ,  Seung Hoon LEE ,  In Yong SEO ,  Kyoung Taek PARK

IPC分类号： F01N3/20 ,  F01N3/28 ,  D04H1/728 ,  D01D5/00 ,  B01D29/11 ,  B01D39/16

CPC分类号： F01N3/208 ,  B01D29/111 ,  B01D39/1623 ,  B01D46/546 ,  B01D2239/025 ,  B01D2239/0421 ,  B01D2239/0631 ,  B01D2239/0654 ,  B01D2239/1216 ,  B01D2279/35 ,  D01D5/0084 ,  D04H1/728 ,  F01N3/2066 ,  F01N3/2896 ,  F01N2610/02 ,  F01N2610/1413 ,  F01N2610/1426 ,  F01N2610/1466

摘要： Provided is a nanofiber vent device for a urea water tank including a filter unit for discharging gas generated in the tank main body and preventing external dust, foreign matter, and moisture from flowing into the tank main body, as a vent device that is installed in a tank main body storing urea water and discharging gas inside the tank main body to the outside.

公开(公告)号：US20180274131A1

公开(公告)日：2018-09-27

申请号：US15763197

申请日：2016-10-03

申请人： Christophe Pierre Edouard NAZ ,  Xeltis, BV

发明人： Christophe Pierre Edouard Naz ,  Anandkumar Nandakumar ,  Oleg Svanidze ,  Martijn Antonius Johannes Cox ,  Fabio Zomer Volpato

IPC分类号： D01D5/00 ,  D04H1/728 ,  A61L27/34 ,  A61L27/18

CPC分类号： D01D5/0084 ,  A61L27/18 ,  A61L27/34 ,  A61L31/10 ,  A61L2420/02 ,  D01D5/0046 ,  D01D5/0061 ,  D01D5/0069 ,  D01D5/0092 ,  D04H1/728 ,  D10B2509/06

摘要： Endoluminal and other as implantable prostheses are fabricated in electrospinning apparatus including a target and an applicator. A solution comprising a polymer and a solvent is directed to the target with a first electrical potential between the target and the applicator to produce a first set of fibers. The same or another solution is continued to be delivered through the applicator onto the target while applying a second electrical potential to produce a second set of fibers having a second solvent fraction, and the same or different solution may be delivered while applying a third potential difference to produce a laminated structure having at least three layers. By properly controlling the electrical potentials and solvent fractions, an adhesive layer can be formed to serve a glue or adhesive between the inner and outer layers, and a stent or other scaffold may be positioned between the inner and outer layers to form a covered stent or graft.

公开(公告)号：US20180264248A1

公开(公告)日：2018-09-20

申请号：US15972611

申请日：2018-05-07

申请人： Cardiac Pacemakers, Inc.

发明人： Adegbola O. Adenusi ,  James P. Rohl ,  David R. Wulfman ,  Joseph T. Delaney, JR. ,  Adeniyi Aremu

IPC分类号： A61M39/08 ,  B32B1/08 ,  A61L29/04 ,  D01D5/098 ,  D01D5/00 ,  B32B27/12 ,  B32B27/08 ,  B32B5/02 ,  A61N1/05 ,  A61L31/14 ,  A61L31/10 ,  A61L31/06 ,  A61L31/04 ,  A61L29/14 ,  A61L29/08 ,  A61L29/06 ,  A61M39/00 ,  C08L71/02 ,  C08L39/06 ,  C08L75/04 ,  C08L83/04

CPC分类号： A61M39/08 ,  A61L29/041 ,  A61L29/06 ,  A61L29/085 ,  A61L29/145 ,  A61L29/146 ,  A61L31/048 ,  A61L31/06 ,  A61L31/10 ,  A61L31/145 ,  A61L31/146 ,  A61M39/00 ,  A61N1/0541 ,  A61N1/056 ,  B32B1/08 ,  B32B5/02 ,  B32B5/022 ,  B32B27/08 ,  B32B27/12 ,  B32B2262/0238 ,  B32B2535/00 ,  D01D5/0023 ,  D01D5/0076 ,  D01D5/0084 ,  D01D5/0985 ,  Y10T428/1372 ,  C08L71/02 ,  C08L39/06 ,  C08L75/04 ,  C08L83/04

摘要： A medical device made of a hybrid polymeric structure includes a tubular body including a first layer and a second layer. The first layer includes a fibrous matrix comprising a plurality of randomly oriented nanofibers made at least in part of a first polymeric material and pores formed between at least a portion of the nanofibers. The second layer is made at least in part of a second polymeric material. At least a portion of the second layer is disposed about and between the plurality of nanofibers such that at least a portion of the second polymeric material is embedded into at least a portion of the pores of the fibrous matrix.

公开(公告)号：US09987120B2

公开(公告)日：2018-06-05

申请号：US14851946

申请日：2015-09-11

申请人： NEOGRAFT TECHNOLOGIES, INC.

发明人： Lorenzo Soletti ,  Mohammed S. El-Kurdi ,  Jon McGrath ,  J. Christopher Flaherty

IPC分类号： B29C53/58 ,  B29C65/00 ,  B32B37/00 ,  A61F2/04 ,  A61F2/06 ,  B29C47/00 ,  H05B7/00 ,  B27N3/14 ,  B29C33/04 ,  B29C47/88 ,  D04H1/728 ,  D01D5/00 ,  D04H3/073 ,  D04H1/76 ,  B05D1/00 ,  B05D1/42 ,  B29C65/48 ,  B32B1/08 ,  B29C47/90

CPC分类号： A61F2/062 ,  A61F2/06 ,  B05D1/007 ,  B05D1/42 ,  B29C47/0023 ,  B29C47/908 ,  B29C65/48 ,  B29C66/5221 ,  B32B1/08 ,  D01D5/0084 ,  D04H1/728 ,  D04H1/76 ,  D04H3/073

摘要： In some aspects, a system for applying a fiber matrix on a tubular conduit is provided. The system can include a tubular conduit, a mandrel and a fiber matrix delivery assembly. The mandrel can comprise an elongate shaft and a rolling membrane configured to atraumatically engage the tubular conduit.

公开(公告)号：US20170268130A1

公开(公告)日：2017-09-21

申请号：US15272470

申请日：2016-09-22

申请人： National Taiwan University of Science and Technology

发明人： Chang-Mou Wu ,  I-Ting Chen ,  Jo-Cheng Chiang

IPC分类号： D01D5/00 ,  B33Y30/00 ,  B33Y50/02 ,  B29C67/00

CPC分类号： B33Y50/02 ,  B29C64/106 ,  B29C64/112 ,  B29C64/209 ,  B29C64/236 ,  B29C64/241 ,  B29C64/25 ,  B29C64/364 ,  B29K2105/0067 ,  B33Y10/00 ,  B33Y30/00 ,  D01D5/0023 ,  D01D5/0069 ,  D01D5/0076 ,  D01D5/0084 ,  D01D5/096 ,  D01D5/098

摘要： An ultrafine fiber printing system contains a moving deck having a nozzle seat that disposed on the moving deck. A pipe is installed in the nozzle seat and a nozzle is disposed at the bottom end of the pipe. The upper portion and the lower portion of the pipe are combined with a heat dissipating unit and heater respectively. The top end of the pipe is connected to a feed tube having an outer end being connected with a thread squeezer. A printing platform is disposed around the moving deck. The nozzle is connected to a static electricity supply and the fiber carrier is grounded. An electric field is formed between the nozzle and the fiber carrier. The droplets exported from the nozzle are stretched into ultrafine fibers to form a patterned fabric or product.

公开(公告)号：US09745644B2

公开(公告)日：2017-08-29

申请号：US14597654

申请日：2015-01-15

申请人： MYONGJI UNIVERSITY INDUSTRY AND ACADEMIA COOPERATION FOUNDATION

发明人： Wook-Jin Chung ,  Myoung Jun Park ,  Grace M. Nisola ,  Arnel B. Beltran ,  Rey Eliseo C. Torrejos ,  Jeong Gil Seo ,  Seong-Poong Lee ,  Young Deuk Yoo

IPC分类号： D01F1/02 ,  D01F1/10 ,  D06M11/11 ,  C22B26/12 ,  D01D5/00 ,  B01J20/04 ,  B01J20/06 ,  B01J20/28 ,  C02F103/08 ,  C02F101/20

CPC分类号： C22B26/12 ,  B01J20/041 ,  B01J20/06 ,  B01J20/28033 ,  B01J20/28038 ,  C02F2101/20 ,  C02F2103/08 ,  D01D5/003 ,  D01D5/0038 ,  D01D5/0046 ,  D01D5/0084

摘要： Disclosed are a composite nanofiber membrane for the adsorption of lithium, a method for preparing the same, and a lithium recovery apparatus and method using the same. The composite nanofiber membrane for the adsorption of lithium is immobilized with manganese oxide selectively adsorptive of lithium. The composite nanofiber membrane for lithium adsorption exhibits high selectivity for lithium ions and allows for the rapid and easy diffusion of lithium ions through interstitial spaces of the adsorbent. Particularly, the lithium recovery apparatus using the composite nanofiber membrane for lithium adsorption is able to effectively adsorb lithium ions dissolved in seawater in a selective manner within a short period of time, thus reducing the time taken for the adsorption process.

公开(公告)号：US20170016144A1

公开(公告)日：2017-01-19

申请号：US15281424

申请日：2016-09-30

申请人： THE OHIO STATE UNIVERSITY RESEARCH FOUNDATION

发明人： Susan V. Olesik ,  Jonathan E. Clark ,  Jeremy K. Steach ,  Joseph W. Zewe

IPC分类号： D01D5/00 ,  B01D15/20 ,  G01N30/06 ,  B01J20/28 ,  G01N30/93 ,  D01F9/12 ,  B01J20/286

CPC分类号： D01D5/0084 ,  B01D15/20 ,  B01J20/28007 ,  B01J20/28033 ,  B01J20/28035 ,  B01J20/286 ,  B01J20/3293 ,  B01J20/3295 ,  B01J2220/54 ,  B05D5/00 ,  B82Y30/00 ,  D01F9/12 ,  G01N30/06 ,  G01N30/93 ,  G01N2030/009 ,  G01N2030/062

摘要： A supported nanofiber medium useful for segregating chemical species is provided by selecting a polymer, selecting a substrate; and electrospinning the polymer to form a nanofiber medium on the supporting substrate. When the substrate is a planar surface, the nanofiber medium will be a mat suitable for conducting chromatographic separation. When the substrate is a filament, the nanofiber medium is an annular mat suitable for solid phase microextraction. The nanofiber media formed may be selectively cross-linked and at least partially carbonized to carbon nanofibers. The nanofiber medium is supported on the substrate without the use of binder material.

摘要翻译： 通过选择聚合物，选择底物提供了可用于分离化学物质的负载型纳米纤维介质; 并静电纺丝聚合物以在支撑基底上形成纳米纤维介质。 当基材是平面时，纳米纤维介质将是适于进行色谱分离的垫。 当基底是细丝时，纳米纤维介质是适用于固相微萃取的环形垫。 形成的纳米纤维介质可以选择性地交联并且至少部分地碳化成碳纳米纤维。 纳米纤维介质在不使用粘合剂材料的情况下被支撑在基底上。