公开(公告)号：US20170202966A1

公开(公告)日：2017-07-20

申请号：US15315699

申请日：2015-06-02

Applicant: UNIVERSITY OF EXETER

Inventor： Mark Elliott WOOD ,  Paul Graham WINYARD ,  Daniel Colin Jeremy FERGUSON ,  Matthew WHITEMAN ,  Alison CURNOW ,  Alexis PERRY

IPC: A61K41/00 ,  A61K31/67

CPC classification number: A61K41/0061 ,  A61K31/385 ,  A61K31/44 ,  A61K31/445 ,  A61K31/454 ,  A61K31/67 ,  A61K31/7135 ,  A61K33/24 ,  A61K41/0071 ,  A61K47/54

Abstract: Compounds for use The invention relates to a combination comprising (i) a compound A comprising a mitochondrial targeting group linked to a group capable of releasing hydrogen sulfide or a pharmaceutically acceptable salt thereof or a prodrug thereof, an inhibitor of the thioredoxin antioxidant system or a pharmaceutically acceptable salt thereof or a prodrug thereof, and/or a nitroxide or a pharmaceutically acceptable salt thereof or a prodrug thereof; and (ii) a photosensitizer or photosensitizer precursor; for use in photodynamic therapy

公开(公告)号：US20180161430A1

公开(公告)日：2018-06-14

申请号：US15890576

申请日：2018-02-07

Applicant: UNIVERSITY OF EXETER

Inventor： Mark Elliott WOOD ,  Paul Graham WINYARD ,  Daniel Colin Jeremy FERGUSON ,  Matthew WHITEMAN ,  Alison CURNOW ,  Alexis PERRY

IPC: A61K41/00 ,  A61K31/67

CPC classification number: A61K41/0061 ,  A61K31/385 ,  A61K31/44 ,  A61K31/445 ,  A61K31/454 ,  A61K31/67 ,  A61K31/7135 ,  A61K33/24 ,  A61K41/0071 ,  A61K47/54

Abstract: The invention relates to a combination comprising(i) a compound A comprising a mitochondrial targeting group linked to a group capable of releasing hydrogen sulfide or a pharmaceutically acceptable salt thereof or a prodrug thereof, an inhibitor of the thioredoxin antioxidant system or a pharmaceutically acceptable salt thereof or a prodrug thereof, and/or a nitroxide or a pharmaceutically acceptable salt thereof or a prodrug thereof; and (ii) a photosensitizer or photosensitizer precursor; for use in photodynamic therapy.