公开(公告)号：US20180038873A1

公开(公告)日：2018-02-08

申请号：US15549166

申请日：2016-02-05

Applicant: UNIVERSITY OF FLORIDA RESEARCH FOUNDATION, INC.

Inventor： SADASIVAN VIDYASAGAR ,  PAUL OKUNIEFF ,  ANAND VIDYASAGAR

IPC: G01N33/68 ,  G01N33/567 ,  C12Q1/68

CPC classification number: G01N33/6893 ,  C12Q1/6876 ,  C12Q1/6883 ,  C12Q2600/158 ,  G01N33/566 ,  G01N33/567 ,  G01N2800/40

Abstract: Embodiments of the present invention are directed to the use of NHE3 as an early biomarker for radiation biodosimetry. In other embodiments, the present invention relates to the use of NHE3 as a biomarker for determining the absorbed radiation dose in a subject who has been exposed to a known or unknown dose of ionizing radiation. Further embodiments relate to the use of NHE3 as a biomarker for determining effectiveness of a therapy for reducing radiation toxicity. Advantageously, the diagnostic and prognostic assays of the present invention are rapid, sensitive, and non-invasive, rendering it useful in civilian and military industries.