公开(公告)号：US10030041B2

公开(公告)日：2018-07-24

申请号：US15227230

申请日：2016-08-03

Applicant: UNIVERSITY OF KANSAS

Inventor： Brian S. J. Blagg ,  Bhaskar Reddy Kusuma ,  Teather Sundstrom

IPC: C07H15/207 ,  C07H15/203 ,  C07C211/17

Abstract: Hsp90 C-terminal inhibitors and pharmaceutical compositions containing such compounds are provided. The compounds of the disclosure are useful for the treatment and/or prevention of neurodegenerative disorders such as diabetic peripheral neuropathy.

公开(公告)号：US10882881B2

公开(公告)日：2021-01-05

申请号：US16783025

申请日：2020-02-05

Applicant: UNIVERSITY OF KANSAS

Inventor： Brian S. J. Blagg ,  Bhaskar Reddy Kusuma ,  Teather Sundstrom

IPC: C07H15/207 ,  C07C211/17 ,  C07H15/203

Abstract: Hsp90 C-terminal inhibitors and pharmaceutical compositions containing such compounds are provided. The compounds of the disclosure are useful for the treatment and/or prevention of neurodegenerative disorders such as diabetic peripheral neuropathy.

公开(公告)号：US20150057240A1

公开(公告)日：2015-02-26

申请号：US14377616

申请日：2013-02-08

Applicant: University of Kansas

Inventor： Brian S. J. Blagg ,  Bhaskar Reddy Kusuma ,  Teather Sundstrom

IPC: C07H15/203 ,  C07C211/17

CPC classification number: C07H15/207 ,  C07C211/17 ,  C07H15/203

Abstract: Hsp90 C-terminal inhibitors and pharmaceutical compositions containing such compounds are provided. The compounds of the disclosure are useful for the treatment and/or prevention of neurodegenerative disorders such as diabetic peripheral neuropathy.

Abstract translation: 提供Hsp90 C末端抑制剂和含有这些化合物的药物组合物。 本公开的化合物可用于治疗和/或预防神经变性疾病如糖尿病性周围神经病变。

公开(公告)号：US12024536B2

公开(公告)日：2024-07-02

申请号：US17863135

申请日：2022-07-12

Applicant: UNIVERSITY OF KANSAS

Inventor： Brian S. J. Blagg ,  Bhaskar Reddy Kusuma ,  Teather Sundstrom

IPC: C07H15/207 ,  C07C211/17 ,  C07H15/203

CPC classification number: C07H15/207 ,  C07C211/17 ,  C07H15/203

Abstract: Hsp90 C-terminal inhibitors and pharmaceutical compositions containing such compounds are provided. The compounds of the disclosure are useful for the treatment and/or prevention of neurodegenerative disorders such as diabetic peripheral neuropathy.

公开(公告)号：US10590157B2

公开(公告)日：2020-03-17

申请号：US16018401

申请日：2018-06-26

Applicant: UNIVERSITY OF KANSAS

Inventor： Brian S. J. Blagg ,  Bhaskar Reddy Kusuma ,  Teather Sundstrom

IPC: C07H15/207 ,  C07H15/203 ,  C07C211/17

Abstract: Hsp90 C-terminal inhibitors and pharmaceutical compositions containing such compounds are provided. The compounds of the disclosure are useful for the treatment and/or prevention of neurodegenerative disorders such as diabetic peripheral neuropathy.

公开(公告)号：US09422320B2

公开(公告)日：2016-08-23

申请号：US14377616

申请日：2013-02-08

Applicant: University of Kansas

Inventor： Brian S. J. Blagg ,  Bhaskar Reddy Kusuma ,  Teather Sundstrom

IPC: C07C211/17 ,  C07H15/203

CPC classification number: C07H15/207 ,  C07C211/17 ,  C07H15/203

Abstract: Hsp90 C-terminal inhibitors and pharmaceutical compositions containing such compounds are provided. The compounds of the disclosure are useful for the treatment and/or prevention of neurodegenerative disorders such as diabetic peripheral neuropathy.

Abstract translation: 提供Hsp90 C末端抑制剂和含有这些化合物的药物组合物。 本公开的化合物可用于治疗和/或预防神经变性疾病如糖尿病性周围神经病变。