公开(公告)号：US11098008B2

公开(公告)日：2021-08-24

申请号：US16776091

申请日：2020-01-29

Applicant: THE UNIVERSITY OF KANSAS

Inventor： Brian S. J. Blagg ,  Rick T. Dobrowsky ,  Mercy Anyika

IPC: C07D311/08 ,  C07C233/18 ,  C07D309/10 ,  C07H15/203 ,  C07D307/20 ,  C07D311/16

Abstract: Provided herein are compounds of the formulas: wherein: n, X2, R3, R3′, R4, R4′, R5, R5′, R6, and R6′ are as defined herein. Pharmaceutical compositions of the compounds are also provided. In some aspects, these compounds may be used for the treatment of diseases, including diabetic peripheral neuropathy or cancer.

公开(公告)号：US10975030B2

公开(公告)日：2021-04-13

申请号：US16346039

申请日：2017-10-31

Applicant: University of Kansas ,  University of South Florida

Inventor： Sanket Jaiprakash Mishra ,  Brian S. J. Blagg ,  Chad Anthony Dickey

IPC: C07D207/325 ,  A61K31/4025 ,  A61P27/06 ,  A61P35/00 ,  C07D401/06

Abstract: The present technology provides compounds according to Formula I or Formula III as well as compositions including such compounds useful for the treatment of metastatic cancer and/or glaucoma.

公开(公告)号：US10927076B2

公开(公告)日：2021-02-23

申请号：US16477398

申请日：2018-01-12

Applicant: University of Kansas

Inventor： Brian S. J. Blagg ,  Caitlin Nicole Kent ,  Anuj Khandelwal ,  Sanket Jaiprakash Mishra

IPC: C07D209/44 ,  C07D209/46 ,  C07D403/06 ,  C07D403/10 ,  C07D413/06 ,  C07D413/10 ,  A61P35/04

Abstract: The present technology provides compounds according to Formula (I) as well as compositions including such compounds useful for the treatment of cancers such as non-small cell lung cancer, bladder cancer, or colon cancer.

公开(公告)号：US11708319B2

公开(公告)日：2023-07-25

申请号：US17375882

申请日：2021-07-14

Applicant: THE UNIVERSITY OF KANSAS

Inventor： Brian S. J. Blagg ,  Rick T. Dobrowsky ,  Mercy Anyika

IPC: C07D311/12 ,  C07C233/18 ,  C07D309/10 ,  C07H15/203 ,  C07D307/20 ,  C07D311/08 ,  C07D311/16

CPC classification number: C07C233/18 ,  C07D307/20 ,  C07D309/10 ,  C07D311/08 ,  C07D311/16 ,  C07H15/203 ,  C07C2601/08 ,  C07C2601/14 ,  C07C2601/16

Abstract: Provided herein are compounds of the formulas:




wherein: n, X2, R3, R3′, R4, R4′, R5, R5′, R6, and R6′ are as defined herein. Pharmaceutical compositions of the compounds are also provided. In some aspects, these compounds may be used for the treatment of diseases, including diabetic peripheral neuropathy or cancer.

公开(公告)号：US10745386B2

公开(公告)日：2020-08-18

申请号：US16018439

申请日：2018-06-26

Applicant: University of Kansas

Inventor： Brian S. J. Blagg ,  Huiping Zhao

IPC: C07D405/12 ,  C07D405/14 ,  C07D413/12 ,  G16H50/50 ,  A61K31/352 ,  A61K31/4025 ,  A61K31/453 ,  A61K31/496 ,  A61K31/5377 ,  A61K45/06 ,  C07D311/16 ,  G06F19/00

Abstract: Compounds of the formulas: wherein: R1-R4, X1, Y1, and A are as defined herein are provided. Pharmaceutical compositions of the compounds are also provided. In some aspects, these compounds are useful for the treatment of a disease or disorder. In some embodiments, the disease or disorder is a proliferative disease such as cancer.

公开(公告)号：US10590065B2

公开(公告)日：2020-03-17

申请号：US15321289

申请日：2015-06-24

Applicant: THE UNIVERSITY OF KANSAS

Inventor： Brian S. J. Blagg ,  Rick T. Dobrowsky ,  Mercy Anyika

IPC: C07C233/18 ,  C07D309/10 ,  C07H15/203 ,  C07D307/20 ,  C07D311/08 ,  C07D311/16

Abstract: Provided herein are compounds of the formulas: (I) wherein: n, X2, R3, R3′, R4, R4′, R5, R5′, R6, and R6′ are as defined herein. Pharmaceutical compositions of the compounds are also provided. In some aspects, these compounds may be used for the treatment of diseases, including diabetic peripheral neuropathy or cancer.

公开(公告)号：US10030041B2

公开(公告)日：2018-07-24

申请号：US15227230

申请日：2016-08-03

Applicant: UNIVERSITY OF KANSAS

Inventor： Brian S. J. Blagg ,  Bhaskar Reddy Kusuma ,  Teather Sundstrom

IPC: C07H15/207 ,  C07H15/203 ,  C07C211/17

Abstract: Hsp90 C-terminal inhibitors and pharmaceutical compositions containing such compounds are provided. The compounds of the disclosure are useful for the treatment and/or prevention of neurodegenerative disorders such as diabetic peripheral neuropathy.

公开(公告)号：US12269798B2

公开(公告)日：2025-04-08

申请号：US17341047

申请日：2021-06-07

Applicant: University of Kansas

Inventor： Brian S. J. Blagg ,  Vincent Matthew Crowley

IPC: C07C69/94 ,  A61K31/216 ,  A61K31/44 ,  A61P27/02 ,  A61P35/04 ,  C07C69/76 ,  C07C69/78 ,  C07C69/88 ,  C07C219/34 ,  C07C229/52 ,  C07D213/55 ,  C07D213/643

Abstract: The present technology provides compounds selective for the Grp94 isoform, as well as compositions including such compounds, that are useful for treatment of multiple myeloma, melanoma, lung cancer, hepatocellular carcinoma, breast cancer, prostate cancer, and/or glaucoma. Methods using the compound are also provided.

公开(公告)号：US10882881B2

公开(公告)日：2021-01-05

申请号：US16783025

申请日：2020-02-05

Applicant: UNIVERSITY OF KANSAS

Inventor： Brian S. J. Blagg ,  Bhaskar Reddy Kusuma ,  Teather Sundstrom

IPC: C07H15/207 ,  C07C211/17 ,  C07H15/203

Abstract: Hsp90 C-terminal inhibitors and pharmaceutical compositions containing such compounds are provided. The compounds of the disclosure are useful for the treatment and/or prevention of neurodegenerative disorders such as diabetic peripheral neuropathy.

公开(公告)号：US10689344B2

公开(公告)日：2020-06-23

申请号：US15034957

申请日：2014-11-07

Applicant: University of Kansas

Inventor： Brian S. J. Blagg ,  Huiping Zhao

IPC: C07D211/46 ,  C07D401/12 ,  C07C235/56 ,  C07D207/08 ,  C07D211/22 ,  C07D487/08 ,  C07D451/06 ,  A61K31/167 ,  A61K31/40 ,  A61K31/445 ,  A61K31/4458 ,  A61K31/4465 ,  A61K31/4535 ,  A61K31/454 ,  A61K31/4545 ,  A61K31/46 ,  A61K45/06 ,  C07D409/12

Abstract: Compounds of the formulas are provided: wherein variables Y1-Y5, X1-X5, A1-A4, X, y, n1, n2, and R1-R15 are as defined herein. Pharmaceutical compositions of the compounds are also provided. In some aspects, these compounds are useful for the treatment of a disease or disorder, including, for example, a proliferative disease, such as cancer.