公开(公告)号：US20170166557A1

公开(公告)日：2017-06-15

申请号：US15443232

申请日：2017-02-27

申请人： University of Kansas ,  University of Louisville Research Foundation, Inc. ,  Southern Research Institute

发明人： Jennifer Golden ,  Jeffrey Aube ,  Donghoon Chung ,  Chad Schroeder ,  Tuanli Yao ,  E. Lucile White ,  Nichole A. Tower

IPC分类号： C07D409/04 ,  C07D403/12 ,  C07D239/95 ,  C07D403/06 ,  C07D401/04 ,  C07D239/91 ,  C07D239/90

CPC分类号： C07D409/04 ,  C07D239/90 ,  C07D239/91 ,  C07D239/95 ,  C07D241/06 ,  C07D401/04 ,  C07D403/06 ,  C07D403/12 ,  C07D409/12

摘要： The present technology relates to compounds and compositions of Formulas and methods using such compounds. The compounds and compositions described herein may be used in the treatment or prophylaxis of diseases associated with an alphavirus, for example, Venezuelan equine encephalitis virus (VEEV).

公开(公告)号：US10087168B2

公开(公告)日：2018-10-02

申请号：US15443232

申请日：2017-02-27

申请人： University of Kansas ,  University of Louisville Research Foundation, Inc. ,  Southern Research Institute

发明人： Jennifer Golden ,  Jeffrey Aube ,  Donghoon Chung ,  Chad Schroeder ,  Tuanli Yao ,  E. Lucile White ,  Nichole A. Tower

IPC分类号： C07D409/04 ,  C07D239/91 ,  C07D403/12 ,  C07D239/90 ,  C07D403/06 ,  C07D401/04 ,  C07D239/95

摘要： The present technology relates to compounds and compositions of Formulas I-III and methods using such compounds. The compounds and compositions described herein may be used in the treatment or prophylaxis of diseases associated with an alphavirus, for example, Venezuelan equine encephalitis virus (VEEV).

公开(公告)号：US20150329499A1

公开(公告)日：2015-11-19

申请号：US14651777

申请日：2013-12-13

申请人： UNIVERSITY OF KANSAS ,  UNIVERSITY OF LOUISVILLE RESEARCH FOUNDATION, INC. ,  SOUTHERN RESEARCH INSTITUTE

发明人： Jennifer Golden ,  Jeffrey Aube ,  Donghoon Chung ,  Chad Schroeder ,  Tuanli Yao ,  E. Lucile White ,  Nichole A. Tower

IPC分类号： C07D241/06

CPC分类号： C07D409/04 ,  C07D239/90 ,  C07D239/91 ,  C07D239/95 ,  C07D241/06 ,  C07D401/04 ,  C07D403/06 ,  C07D403/12 ,  C07D409/12

摘要： The present technology relates to compounds and compositions of Formulas I-III and methods using such compounds. The compounds and compositions described herein may be used in the treatment or prophylaxis of diseases associated with an alphavirus, for example, Venezuelan equine encephalitis virus (VEEV).

摘要翻译： 本技术涉及式I-III的化合物和组合物以及使用这些化合物的方法。 本文所述的化合物和组合物可用于治疗或预防与甲病毒属例如委内瑞兰马脑炎病毒（VEEV）相关的疾病。

公开(公告)号：US09580393B2

公开(公告)日：2017-02-28

申请号：US14651777

申请日：2013-12-13

申请人： University of Kansas ,  University of Louisville Research Foundation, Inc. ,  Southern Research Institute

发明人： Jennifer Golden ,  Jeffrey Aube ,  Donghoon Chung ,  Chad Schroeder ,  Tuanli Yao ,  E. Lucile White ,  Nichole A. Tower

IPC分类号： C07D241/06 ,  C07D239/90 ,  C07D239/91 ,  C07D401/04 ,  C07D403/06 ,  C07D409/04 ,  C07D409/12 ,  C07D239/95

CPC分类号： C07D409/04 ,  C07D239/90 ,  C07D239/91 ,  C07D239/95 ,  C07D241/06 ,  C07D401/04 ,  C07D403/06 ,  C07D403/12 ,  C07D409/12

摘要： The present technology relates to compounds and compositions of Formulas I-III and methods using such compounds. The compounds and compositions described herein may be used in the treatment or prophylaxis of diseases associated with an alphavirus, for example, Venezuelan equine encephalitis virus (VEEV).

摘要翻译： 本技术涉及式I-III的化合物和组合物以及使用这些化合物的方法。 本文所述的化合物和组合物可用于治疗或预防与甲病毒属例如委内瑞兰马脑炎病毒（VEEV）相关的疾病。

公开(公告)号：US10532999B2

公开(公告)日：2020-01-14

申请号：US16149009

申请日：2018-10-01

申请人： University of Kansas ,  University of Louisville Research Foundation, Inc. ,  Southern Research Institute

发明人： Jennifer Golden ,  Jeffrey Aube ,  Donghoon Chung ,  Chad Schroeder ,  Tuanli Yao ,  E. Lucile White ,  Nichole A. Tower

IPC分类号： C07D409/04 ,  C07D239/95 ,  C07D409/12 ,  C07D403/06 ,  C07D401/04 ,  C07D239/91 ,  C07D239/90 ,  C07D403/12 ,  C07D241/06

摘要： The present technology relates to compounds and compositions of Formulas I-III and methods using such compounds. The compounds and compositions described herein may be used in the treatment or prophylaxis of diseases associated with an alphavirus, for example, Venezuelan equine encephalitis virus (VEEV).

公开(公告)号：US20190270730A1

公开(公告)日：2019-09-05

申请号：US16149009

申请日：2018-10-01

申请人： University of Kansas ,  University of Louisville Research Foundation, Inc. ,  Southern Research Institute

发明人： Jennifer Golden ,  Jeffrey Aube ,  Donghoon Chung ,  Chad Schroeder ,  Tuanli Yao ,  E. Lucile White ,  Nichole A. Tower

IPC分类号： C07D409/04 ,  C07D239/95 ,  C07D409/12 ,  C07D403/06 ,  C07D241/06 ,  C07D239/91 ,  C07D239/90 ,  C07D403/12 ,  C07D401/04

摘要： The present technology relates to compounds and compositions of Formulas I-III and methods using such compounds. The compounds and compositions described herein may be used in the treatment or prophylaxis of diseases associated with an alphavirus, for example, Venezuelan equine encephalitis virus (VEEV).

公开(公告)号：US09376452B2

公开(公告)日：2016-06-28

申请号：US14278468

申请日：2014-05-15

申请人： STC.UNM ,  UNIVERSITY OF KANSAS

发明人： Angela Wandinger-Ness ,  Larry Sklar ,  Jacob Agola ,  Zurab Surviladze ,  Jeffrey Aube ,  Jennifer Golden ,  Chad E. Schroeder ,  Denise S. Simpson

IPC分类号： C07D495/04 ,  A61K31/381 ,  A61K45/06

CPC分类号： C07D495/04 ,  A61K31/381 ,  A61K45/06

摘要： This invention relates to compounds and their use as inhibitors or activators of Rab7 GTPase to treat or prevent the onset of Rab 7 GTPase-associated disorders such as neuropathies, cancer, metabolic diseases of bone and lipid storage. The invention is also applicable to infectious diseases where Rab7 is inactivated or its protein-protein interactions are modulated to facilitate intracellular survival of pathogens. The compound described acts as a competitive inhibitor of nucleotide binding and as such also has utility as a scaffold for targeting other small GTPases. In one aspect, methods of treatment of the invention are used to treat or prevent the onset of hereditary sensory neuropathies such as Charcot-Marie-Tooth type 2B disease. Related pharmaceutical compositions, assays, and drug screens are also provided.

摘要翻译： 本发明涉及化合物及其作为Rab7 GTPase的抑制剂或活化剂的用途，用于治疗或预防Rab 7 GTP酶相关疾病如神经病变，癌症，骨骼和脂质储存代谢疾病的发生。 本发明也适用于Rab7灭活或其蛋白质 - 蛋白质相互作用被调节以促进病原体的细胞内存活的感染性疾病。 所描述的化合物作为核苷酸结合的竞争性抑制剂，因此也可用作靶向其他小GTP酶的支架。 一方面，本发明的治疗方法用于治疗或预防遗传性感觉神经病发作，例如Charcot-Marie-Tooth 2B型疾病。 还提供了相关的药物组合物，测定和药物筛选。