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公开(公告)号：US10532999B2
公开(公告)日：2020-01-14
申请号：US16149009
申请日：2018-10-01
申请人： University of Kansas , University of Louisville Research Foundation, Inc. , Southern Research Institute
发明人： Jennifer Golden , Jeffrey Aube , Donghoon Chung , Chad Schroeder , Tuanli Yao , E. Lucile White , Nichole A. Tower
IPC分类号： C07D409/04 , C07D239/95 , C07D409/12 , C07D403/06 , C07D401/04 , C07D239/91 , C07D239/90 , C07D403/12 , C07D241/06
摘要： The present technology relates to compounds and compositions of Formulas I-III and methods using such compounds. The compounds and compositions described herein may be used in the treatment or prophylaxis of diseases associated with an alphavirus, for example, Venezuelan equine encephalitis virus (VEEV).
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公开(公告)号：US20190270730A1
公开(公告)日：2019-09-05
申请号：US16149009
申请日：2018-10-01
申请人： University of Kansas , University of Louisville Research Foundation, Inc. , Southern Research Institute
发明人： Jennifer Golden , Jeffrey Aube , Donghoon Chung , Chad Schroeder , Tuanli Yao , E. Lucile White , Nichole A. Tower
IPC分类号： C07D409/04 , C07D239/95 , C07D409/12 , C07D403/06 , C07D241/06 , C07D239/91 , C07D239/90 , C07D403/12 , C07D401/04
摘要： The present technology relates to compounds and compositions of Formulas I-III and methods using such compounds. The compounds and compositions described herein may be used in the treatment or prophylaxis of diseases associated with an alphavirus, for example, Venezuelan equine encephalitis virus (VEEV).
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公开(公告)号：US10087168B2
公开(公告)日：2018-10-02
申请号：US15443232
申请日：2017-02-27
申请人： University of Kansas , University of Louisville Research Foundation, Inc. , Southern Research Institute
发明人： Jennifer Golden , Jeffrey Aube , Donghoon Chung , Chad Schroeder , Tuanli Yao , E. Lucile White , Nichole A. Tower
IPC分类号： C07D409/04 , C07D239/91 , C07D403/12 , C07D239/90 , C07D403/06 , C07D401/04 , C07D239/95
摘要： The present technology relates to compounds and compositions of Formulas I-III and methods using such compounds. The compounds and compositions described herein may be used in the treatment or prophylaxis of diseases associated with an alphavirus, for example, Venezuelan equine encephalitis virus (VEEV).
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公开(公告)号：US20150329499A1
公开(公告)日：2015-11-19
申请号：US14651777
申请日：2013-12-13
申请人： UNIVERSITY OF KANSAS , UNIVERSITY OF LOUISVILLE RESEARCH FOUNDATION, INC. , SOUTHERN RESEARCH INSTITUTE
发明人： Jennifer Golden , Jeffrey Aube , Donghoon Chung , Chad Schroeder , Tuanli Yao , E. Lucile White , Nichole A. Tower
IPC分类号： C07D241/06
CPC分类号： C07D409/04 , C07D239/90 , C07D239/91 , C07D239/95 , C07D241/06 , C07D401/04 , C07D403/06 , C07D403/12 , C07D409/12
摘要： The present technology relates to compounds and compositions of Formulas I-III and methods using such compounds. The compounds and compositions described herein may be used in the treatment or prophylaxis of diseases associated with an alphavirus, for example, Venezuelan equine encephalitis virus (VEEV).
摘要翻译： 本技术涉及式I-III的化合物和组合物以及使用这些化合物的方法。 本文所述的化合物和组合物可用于治疗或预防与甲病毒属例如委内瑞兰马脑炎病毒（VEEV）相关的疾病。
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公开(公告)号：US09580393B2
公开(公告)日：2017-02-28
申请号：US14651777
申请日：2013-12-13
申请人： University of Kansas , University of Louisville Research Foundation, Inc. , Southern Research Institute
发明人： Jennifer Golden , Jeffrey Aube , Donghoon Chung , Chad Schroeder , Tuanli Yao , E. Lucile White , Nichole A. Tower
IPC分类号： C07D241/06 , C07D239/90 , C07D239/91 , C07D401/04 , C07D403/06 , C07D409/04 , C07D409/12 , C07D239/95
CPC分类号： C07D409/04 , C07D239/90 , C07D239/91 , C07D239/95 , C07D241/06 , C07D401/04 , C07D403/06 , C07D403/12 , C07D409/12
摘要： The present technology relates to compounds and compositions of Formulas I-III and methods using such compounds. The compounds and compositions described herein may be used in the treatment or prophylaxis of diseases associated with an alphavirus, for example, Venezuelan equine encephalitis virus (VEEV).
摘要翻译： 本技术涉及式I-III的化合物和组合物以及使用这些化合物的方法。 本文所述的化合物和组合物可用于治疗或预防与甲病毒属例如委内瑞兰马脑炎病毒（VEEV）相关的疾病。
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公开(公告)号：US20170166557A1
公开(公告)日：2017-06-15
申请号：US15443232
申请日：2017-02-27
申请人： University of Kansas , University of Louisville Research Foundation, Inc. , Southern Research Institute
发明人： Jennifer Golden , Jeffrey Aube , Donghoon Chung , Chad Schroeder , Tuanli Yao , E. Lucile White , Nichole A. Tower
IPC分类号： C07D409/04 , C07D403/12 , C07D239/95 , C07D403/06 , C07D401/04 , C07D239/91 , C07D239/90
CPC分类号： C07D409/04 , C07D239/90 , C07D239/91 , C07D239/95 , C07D241/06 , C07D401/04 , C07D403/06 , C07D403/12 , C07D409/12
摘要： The present technology relates to compounds and compositions of Formulas and methods using such compounds. The compounds and compositions described herein may be used in the treatment or prophylaxis of diseases associated with an alphavirus, for example, Venezuelan equine encephalitis virus (VEEV).
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公开(公告)号：US20180086749A1
公开(公告)日：2018-03-29
申请号：US15573240
申请日：2016-05-10
发明人： Jennifer E. Golden , Donghoon Chung
IPC分类号： C07D417/12 , C07D417/04 , C07D277/82
CPC分类号： C07D417/12 , C07D277/82 , C07D417/04
摘要： The present technology is directed to compounds, compositions, and methods to treat a viral infection. The compound is according to Formula I or a solvate and/or pharmaceutically acceptable salt thereof. The technology is especially suited to treat Chikungunya virus, Zika virus, Venezuelan equine encephalitis virus, and/or respiratory syncytial virus infection.
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