公开(公告)号：US20210115083A1

公开(公告)日：2021-04-22

申请号：US16813087

申请日：2020-03-09

Applicant: University of Kentucky Research Foundation

Inventor： Peixuan Guo ,  Carlo M. Croce ,  Tae Jin Lee ,  Farzin Haque ,  Hui Li

IPC: C07H21/02 ,  C12N15/113 ,  A61K47/55 ,  C12N15/11 ,  A61K47/69 ,  A61P35/00 ,  C12N15/115

Abstract: The presently-disclosed subject matter relates to an artificial RNA nanostructure molecule and method to treat brain tumor in a subject. More particularly, the presently disclosed subject matter relates to a RNA nanostructure containing a multiple branched RNA nanoparticle, a brain tumor targeting module, and an effective amount of a therapeutic agent. Further, the presently disclosed subject matter relates to a method of using the RNA nanostructure composition to treat brain tumor in a subject having or at risk of having brain tumor.

公开(公告)号：US11325939B2

公开(公告)日：2022-05-10

申请号：US16813087

申请日：2020-03-09

Applicant: University of Kentucky Research Foundation

Inventor： Peixuan Guo ,  Carlo M. Croce ,  Tae Jin Lee ,  Farzin Haque ,  Hui Li

IPC: C07H21/04 ,  C07H21/02 ,  C12N15/113 ,  A61K47/55 ,  C12N15/11 ,  A61K47/69 ,  A61P35/00 ,  C12N15/115 ,  B82Y5/00

Abstract: The presently-disclosed subject matter relates to an artificial RNA nanostructure molecule and method to treat brain tumor in a subject. More particularly, the presently disclosed subject matter relates to a RNA nanostructure containing a multiple branched RNA nanoparticle, a brain tumor targeting module, and an effective amount of a therapeutic agent. Further, the presently disclosed subject matter relates to a method of using the RNA nanostructure composition to treat brain tumor in a subject having or at risk of having brain tumor.

公开(公告)号：US10584144B2

公开(公告)日：2020-03-10

申请号：US15554360

申请日：2016-03-09

Applicant: UNIVERSITY OF KENTUCKY RESEARCH FOUNDATION

Inventor： Peixuan Guo ,  Carlo M. Croce ,  Tae Jin Lee ,  Farzin Haque ,  Hui Li

IPC: C07H21/04 ,  C07H21/02 ,  C12N15/113 ,  A61K47/55 ,  C12N15/11 ,  A61K47/69 ,  A61P35/00 ,  C12N15/115 ,  B82Y5/00

Abstract: The presently-disclosed subject matter relates to an artificial RNA nanostructure molecule and method to treat brain tumor in a subject. More particularly, the presently disclosed subject matter relates to a RNA nanostructure containing a multiple branched RNA nanoparticle, a brain tumor targeting module, and an effective amount of a therapeutic agent. Further, the presently disclosed subject matter relates to a method of using the RNA nanostructure composition to treat brain tumor in a subject having or at risk of having brain tumor.

公开(公告)号：US11085044B2

公开(公告)日：2021-08-10

申请号：US15555822

申请日：2016-03-09

Applicant: UNIVERSITY OF KENTUCKY RESEARCH FOUNDATION

Inventor： Peixuan Guo ,  Dan Shu ,  Yi Shu ,  Hui Li ,  Farzin Haque

IPC: C07H21/04 ,  A61K48/00 ,  C12N15/113 ,  C12N15/115 ,  C07H21/02 ,  A61P35/00 ,  A61K9/51 ,  B82Y5/00

Abstract: The presently-disclosed subject matter relates to RNA-based composition and method to treat breast cancer in a subject. More particularly, the presently disclosed subject matter relates to a RNA nanostructure and composition containing a multiple branched RNA nanoparticle, a breast cancer targeting module, and an effective amount of a breast cancer therapeutic agent. Further, the presently disclosed subject matter relates to a method of using the RNA nanoparticle composition to treat breast cancer in a subject having or at risk of having breast cancer.

公开(公告)号：US20190119682A1

公开(公告)日：2019-04-25

申请号：US15555822

申请日：2016-03-09

Applicant: UNIVERSITY OF KENTUCKY RESEARCH FOUNDATION

Inventor： Peixuan Guo ,  Dan Shu ,  Yi Shu ,  Hui Li ,  Farzin Haque

IPC: C12N15/113 ,  C12N15/115 ,  A61K9/51 ,  A61P35/00

Abstract: The presently-disclosed subject matter relates to RNA-based composition and method to treat breast cancer in a subject. More particularly, the presently disclosed subject matter relates to a RNA nanostructure and composition containing a multiple branched RNA nanoparticle, a breast cancer targeting module, and an effective amount of a breast cancer therapeutic agent. Further, the presently disclosed subject matter relates to a method of using the RNA nanoparticle composition to treat breast cancer in a subject having or at risk of having breast cancer.

公开(公告)号：US20190106452A1

公开(公告)日：2019-04-11

申请号：US15554360

申请日：2016-03-09

Applicant: UNIVERSITY OF KENTUCKY RESEARCH FOUNDATION

Inventor： Peixuan Guo ,  Carlo M. Croce ,  Tae Jin Lee ,  Farzin Haque ,  Hui Li

IPC: C07H21/02 ,  A61P35/00 ,  A61K47/55 ,  C12N15/113 ,  C12N15/115

CPC classification number: C07H21/02 ,  A61K47/551 ,  A61K47/6929 ,  A61P35/00 ,  B82Y5/00 ,  C12N15/111 ,  C12N15/113 ,  C12N15/115 ,  C12N2310/113 ,  C12N2310/14 ,  C12N2310/3231 ,  C12N2310/52 ,  C12N2320/32

Abstract: The presently-disclosed subject matter relates to an artificial RNA nanostructure molecule and method to treat brain tumor in a subject. More particularly, the presently disclosed subject matter relates to a RNA nanostructure containing a multiple branched RNA nanoparticle, a brain tumor targeting module, and an effective amount of a therapeutic agent. Further, the presently disclosed subject matter relates to a method of using the RNA nanostructure composition to treat brain tumor in a subject having or at risk of having brain tumor.