公开(公告)号：US09133114B2

公开(公告)日：2015-09-15

申请号：US13752482

申请日：2013-01-29

申请人： UNIVERSITY OF MARYLAND, BALTIMORE ,  UNIVERSITY OF MARYLAND, COLLEGE PARK

发明人： Yihua (Bruce) Yu ,  Xuyi Yue

IPC分类号： A61K51/06 ,  C07C323/12 ,  A61K49/12

CPC分类号： C07C323/12 ,  A61K49/124 ,  A61K51/06

摘要： The present invention provides for monodispersed dendrimers having a core, branches and periphery ends, wherein the number of branches increases exponentially from the core to the periphery end and the length of the branches increases exponentially from the periphery end to the core, thereby providing for attachment of chemical species at the periphery ends without exhibiting steric hindrance.

摘要翻译： 本发明提供了具有核心，分支和周边末端的单分散树枝状大分子，其中分支数目从核心到周边端呈指数级增加，并且分支的长度从周边端到核心指数地增加，从而提供附着 的化学物质在周边端部没有表现出空间位阻。

公开(公告)号：US12061160B2

公开(公告)日：2024-08-13

申请号：US18170114

申请日：2023-02-16

申请人： UNIVERSITY OF MARYLAND, BALTIMORE ,  ACCESS TO ADVANCED HEALTH INSTITUTE

发明人： Yihua (Bruce) Yu ,  Marc Taraban ,  Christopher Fox

IPC分类号： G01N24/08 ,  G01N33/15

CPC分类号： G01N24/082 ,  G01N33/15

摘要： A method of using the transverse relaxation rate (R2) of solvent NMR signal to noninvasively assess if an alum-containing product, such as a vaccine, has been acceptably resuspended for use following transport and/or storage. This technique allows for the manufacturer and/or distributor and/or end user to monitor for unexpected stressors associated with transport and/or storage including, but not limited to, temperature fluctuations, pH changes, vigorous shaking during transportation, exposure to sunlight, and freezing.

公开(公告)号：US11543371B2

公开(公告)日：2023-01-03

申请号：US17030088

申请日：2020-09-23

申请人： UNIVERSITY OF MARYLAND, BALTIMORE

发明人： Yihua (Bruce) Yu ,  Marc B. Taraban

IPC分类号： G01N24/08 ,  G01R33/46 ,  G01N33/15

摘要： A method of using the transverse relaxation rate (R2) of solvent NMR signal to detect filling errors of an alum-containing product in real-time in-line during manufacturing, for example during a fill-finish unit operation. This technique can be used for quality control in vaccine manufacturing to ensure the delivery of the correct concentration of alum-containing product to the product container such as a vial or pre-filled syringe.

公开(公告)号：US11946885B2

公开(公告)日：2024-04-02

申请号：US17842990

申请日：2022-06-17

申请人： UNIVERSITY OF MARYLAND, BALTIMORE

发明人： Yihua (Bruce) Yu ,  Marc Taraban

IPC分类号： G01N24/08 ,  C12N15/86 ,  G01R33/44

CPC分类号： G01N24/08 ,  C12N15/86 ,  G01R33/448 ,  C12N2750/14143

摘要： A method of using the relaxation rate (R1 and/or R2) of solvent NMR signal to noninvasively assess whether viral capsids in a capsid preparation are full or empty, and the percentage of full capsids if the vial contains a mixture of full and empty capsids. The method can simply, rapidly, and non-invasively prove the safety and potency of the capsid preparation and thus whether the capsid preparation can be approved for clinical use, without requiring any sample preparation or reagent addition.

公开(公告)号：US11585770B2

公开(公告)日：2023-02-21

申请号：US16593145

申请日：2019-10-04

申请人： UNIVERSITY OF MARYLAND, BALTIMORE ,  ACCESS TO ADVANCED HEALTH INSTITUTE

发明人： Yihua (Bruce) Yu ,  Marc Taraban ,  Christopher Fox

IPC分类号： G01N24/08 ,  G01N33/15

摘要： A method of using the transverse relaxation rate (R2) of solvent NMR signal to noninvasively assess alum-containing products such as vaccines. This technique can be used for quality control in vaccine manufacturing (e.g., fill-finish step) to determine the evenness of alum filling level as well as extent of alum particle sedimentation in filled and sealed products.

公开(公告)号：US11971374B2

公开(公告)日：2024-04-30

申请号：US18149233

申请日：2023-01-03

申请人： UNIVERSITY OF MARYLAND, BALTIMORE

发明人： Yihua (Bruce) Yu ,  Marc B. Taraban

IPC分类号： G01N24/08 ,  G01N33/15 ,  G01R33/46

CPC分类号： G01N24/084 ,  G01N24/085 ,  G01N33/15 ,  G01R33/46

摘要： A method of using the transverse relaxation time (T2) of solvent NMR signal to detect filling errors of an alum-containing product in real-time and in-line during manufacturing, for example during a fill-finish unit operation. This method can be used for quality control in vaccine manufacturing to ensure the delivery of the correct concentration of alum-containing product to the product container such as a vial or pre-filled syringe.

公开(公告)号：US11914013B2

公开(公告)日：2024-02-27

申请号：US17401709

申请日：2021-08-13

申请人： UNIVERSITY OF MARYLAND, BALTIMORE

发明人： Yihua (Bruce) Yu ,  Marc B. Taraban

IPC分类号： G01R33/50 ,  G01N24/08 ,  G01N15/04 ,  G01R33/34

CPC分类号： G01R33/50 ,  G01N15/04 ,  G01N24/082 ,  G01R33/34092

摘要： A method for using water proton transverse relaxation rate R2(T) to monitor, in real time, the sedimentation rates of multiphase mixtures such as drug products and drug substances. The method provides a practical application of wNMR as an analytical tool to study and provide higher quality and more efficient multiphase mixtures.