公开(公告)号：US20240191230A1

公开(公告)日：2024-06-13

申请号：US18380871

申请日：2023-10-17

Applicant: UNIVERSITY OF MASSACHUSETTS

Inventor： Jonathan Watts ,  Io Long Chan ,  Feng Wang ,  Minwook Shin

IPC: C12N15/113

CPC classification number: C12N15/113 ,  C12N2310/11 ,  C12N2310/14 ,  C12N2310/344 ,  C12N2310/3519

Abstract: This disclosure relates to compounds (“siRNASO”) comprising a double stranded RNA (dsRNA) attached to antisense oligonucleotides (ASO) and heteroduplex oligonucleotides (HDO). Also provided are methods of inhibiting gene expression with the same.

公开(公告)号：US20220340903A1

公开(公告)日：2022-10-27

申请号：US17760504

申请日：2020-09-25

Applicant: University of Massachusetts

Inventor： Ingolf Bach ,  Feng Wang ,  Anastasia Khvorova ,  Chantal Ferguson

IPC: C12N15/113

Abstract: Methods for the treatment of weight-related disorders, including obesity and disorders associated with obesity, as well as underweight and disorders associated with underweight, by modulating Rlim levels.

公开(公告)号：US20210285002A1

公开(公告)日：2021-09-16

申请号：US17175156

申请日：2021-02-12

Applicant: UNIVERSITY OF MASSACHUSETTS

Inventor： Feng Wang ,  Jonathan Watts

IPC: C12N15/113

Abstract: The present disclosure provides antisense compounds, methods, and compositions for increasing FXN gene expression. The present disclosure provides antisense compounds, methods, and compositions for the treatment, prevention, or amelioration of diseases, disorders, and conditions associated with FXN in a subject in need thereof. Also contemplated are antisense compounds and methods for the preparation of a medicament for the treatment, prevention, or amelioration of a disease, disorder, or condition associated with FXN.