公开(公告)号：US20240191230A1

公开(公告)日：2024-06-13

申请号：US18380871

申请日：2023-10-17

Applicant: UNIVERSITY OF MASSACHUSETTS

Inventor： Jonathan Watts ,  Io Long Chan ,  Feng Wang ,  Minwook Shin

IPC: C12N15/113

CPC classification number: C12N15/113 ,  C12N2310/11 ,  C12N2310/14 ,  C12N2310/344 ,  C12N2310/3519

Abstract: This disclosure relates to compounds (“siRNASO”) comprising a double stranded RNA (dsRNA) attached to antisense oligonucleotides (ASO) and heteroduplex oligonucleotides (HDO). Also provided are methods of inhibiting gene expression with the same.