公开(公告)号：US20230021431A1

公开(公告)日：2023-01-26

申请号：US17333839

申请日：2021-05-28

Applicant: UNIVERSITY OF MASSACHUSETTS

Inventor： Anastasia Khvorova ,  Jonathan Watts ,  Zachary Kennedy ,  Annabelle Biscans ,  Bruno Miguel da Cruz Godinho ,  Chantal Ferguson ,  Dimas Echeverria Moreno ,  Ken Yamada ,  Daniel O'Reilly ,  Kathryn Monopoli ,  Vignesh Narayan Hariharan ,  Qi Tang ,  Sarah Davis ,  Samuel Hildebrand ,  Socheata Ly ,  Minwook Shin ,  Pranathi Meda Krishnamurthy ,  Nicholas McHugh ,  Jacquelyn Sousa ,  Jillian Caiazzi ,  Yann Thillier ,  Gitali Devi

IPC: C12N15/113

Abstract: This disclosure relates to novel SARS-CoV-2 targeting sequences. Novel SARS-CoV-2 targeting oligonucleotides for the treatment of SARS-CoV-2 infection are also provided.

公开(公告)号：US20240425860A1

公开(公告)日：2024-12-26

申请号：US18675670

申请日：2024-05-28

Applicant: UNIVERSITY OF MASSACHUSETTS

Inventor： Anastasia Khvorova ,  Jonathan Watts ,  Zachary Kennedy ,  Annabelle Biscans ,  Bruno Miguel da Cruz Godinho ,  Chantal Ferguson ,  Dimas Echeverria Moreno ,  Ken Yamada ,  Daniel O'Reilly ,  Kathryn Monopoli ,  Vignesh Narayan Hariharan ,  Qi Tang ,  Sarah Davis ,  Samuel Hildebrand ,  Socheata Ly ,  Minwook Shin ,  Pranathi Meda Krishnamurthy ,  Nicholas McHugh ,  Jacquelyn Sousa ,  Jillian Caiazzi ,  Yann Thillier ,  Gitali Devi

IPC: C12N15/113

Abstract: This disclosure relates to novel SARS-CoV-2 targeting sequences. Novel SARS-CoV-2 targeting oligonucleotides for the treatment of SARS-CoV-2 infection are also provided.

公开(公告)号：US20240366773A1

公开(公告)日：2024-11-07

申请号：US18592676

申请日：2024-03-01

Applicant: UNIVERSITY OF MASSACHUSETTS ,  MCGILL UNIVERSITY

Inventor： Hassan H. Fakih ,  Hanadi Sleiman ,  Anastasia Khvorova ,  Jonathan K. Watts ,  Qi Tang ,  Minwook Shin

IPC: A61K47/56 ,  A61K9/00 ,  A61K31/713 ,  C12N15/113

Abstract: This disclosure provides compositions, systems, and methods for the delivery of therapeutic oligonucleotides to the lung. The oligonucleotide is conjugated to a dendron comprising a hydrophilic end group, a phosphate group, and/or a hydrophobic chain.

公开(公告)号：US12077758B2

公开(公告)日：2024-09-03

申请号：US17333839

申请日：2021-05-28

Applicant: UNIVERSITY OF MASSACHUSETTS

Inventor： Anastasia Khvorova ,  Jonathan Watts ,  Zachary Kennedy ,  Annabelle Biscans ,  Bruno Miguel da Cruz Godinho ,  Chantal Ferguson ,  Dimas Echeverria Moreno ,  Ken Yamada ,  Daniel O′Reilly ,  Kathryn Monopoli ,  Vignesh Narayan Hariharan ,  Qi Tang ,  Sarah Davis ,  Samuel Hildebrand ,  Socheata Ly ,  Minwook Shin ,  Pranathi Meda Krishnamurthy ,  Nicholas McHugh ,  Jacquelyn Sousa ,  Jillian Caiazzi ,  Yann Thillier ,  Gitali Devi

IPC: C12N15/11 ,  C12N15/113

CPC classification number: C12N15/1131 ,  C12N15/1136 ,  C12N15/1137 ,  C12N2310/14 ,  C12N2310/315 ,  C12N2310/321 ,  C12N2310/351 ,  C12N2310/3515 ,  C12N2320/32

Abstract: This disclosure relates to novel SARS-CoV-2 targeting sequences. Novel SARS-CoV-2 targeting oligonucleotides for the treatment of SARS-CoV-2 infection are also provided.

公开(公告)号：US20240191230A1

公开(公告)日：2024-06-13

申请号：US18380871

申请日：2023-10-17

Applicant: UNIVERSITY OF MASSACHUSETTS

Inventor： Jonathan Watts ,  Io Long Chan ,  Feng Wang ,  Minwook Shin

IPC: C12N15/113

CPC classification number: C12N15/113 ,  C12N2310/11 ,  C12N2310/14 ,  C12N2310/344 ,  C12N2310/3519

Abstract: This disclosure relates to compounds (“siRNASO”) comprising a double stranded RNA (dsRNA) attached to antisense oligonucleotides (ASO) and heteroduplex oligonucleotides (HDO). Also provided are methods of inhibiting gene expression with the same.