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公开(公告)号：US11672867B2
公开(公告)日：2023-06-13
申请号：US16497145
申请日：2018-03-30
CPC分类号： A61K47/55 , A61K47/6931 , B82Y5/00
摘要： The invention provides polymers and polymer-based nano-structures, in particular, polymers and polymer network to which biomolecules (e.g., proteins, antibodies, peptide aptamers) can be covalently conjugated and stably encapsulated therein and be controllably delivered and released upon degradation of the nano-structures in response to specific microenvironment, and compositions and methods of preparation and use thereof.
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公开(公告)号：US11434317B2
公开(公告)日：2022-09-06
申请号：US16849943
申请日：2020-04-15
IPC分类号： C08F299/04 , C08F220/38 , A61K47/58 , A61K47/54 , B82Y5/00
摘要： The invention provides novel polymers, crosslinked polymer-nucleic acid complexes, lipid-polymer-nucleic acid-based complexation and nanoassemblies, and nanoassembly-based intracellular delivery of nucleic acids and controlled release thereof upon degradation of the nanoassemblies in response to specific microenvironment in the cell, and compositions and methods of preparation and use thereof.
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公开(公告)号：US20210017314A1
公开(公告)日：2021-01-21
申请号：US16932774
申请日：2020-07-19
发明人： Sankaran Thayumanavan , Bin Liu
IPC分类号： C08F220/28 , A61K47/60 , A61K47/65
摘要： The invention provides novel polymer-protein conjugates and molecular assemblies for controlled intracellular delivery of proteins, and compositions and methods of preparation and use thereof.
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公开(公告)号：US20200332047A1
公开(公告)日：2020-10-22
申请号：US16849943
申请日：2020-04-15
IPC分类号： C08F299/04 , C08F220/38 , A61K47/54 , A61K47/58
摘要： The invention provides novel polymers, crosslinked polymer-nucleic acid complexes, lipid-polymer-nucleic acid-based complexation and nanoassemblies, and nanoassembly-based intracellular delivery of nucleic acids and controlled release thereof upon degradation of the nanoassemblies in response to specific microenvironment in the cell, and compositions and methods of preparation and use thereof.
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5.发明申请公开(公告)号：US20200282066A1
公开(公告)日：2020-09-10
申请号：US16497145
申请日：2018-03-30
摘要： The invention provides polymers and polymer-based nano-structures, in particular, polymers and polymer network to which biomolecules (e.g., proteins, antibodies, peptide aptamers) can be covalently conjugated and stably encapsulated therein and be controllably delivered and released upon degradation of the nano-structures in response to specific microenvironment, and compositions and methods of preparation and use thereof.
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6.发明申请公开(公告)号：US20180140710A1
公开(公告)日：2018-05-24
申请号：US15568468
申请日：2016-05-03
CPC分类号： A61K47/58 , A61K9/51 , A61K47/6903 , G01N30/72 , G01R33/46
摘要： The invention provides polymers and polymeric nanogels that stably encapsulate peptides and proteins, which are controllably released upon degradable of the nano-structures in response to specific microenvironment, and compositions and methods of preparation and use thereof.
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公开(公告)号：US20150209447A1
公开(公告)日：2015-07-30
申请号：US14421882
申请日：2013-09-10
IPC分类号： A61K47/48 , C08F20/68 , A61K31/485 , C08L33/14
CPC分类号： A61K47/6949 , A61K9/06 , A61K31/485 , A61K47/42 , C08F20/68 , C08F120/24 , C08F220/28 , C08F2438/03 , C08L33/14 , C08F2220/286 , C08F2220/1875 , C08F2220/385 , C08F2220/1825 , C08F2220/1841 , C08F2220/1858 , C08F220/24 , C08F220/54 , C08F220/60 , C08F2220/606
摘要： The invention provides powerful methods and compositions for designing, selecting, fine-tuning and optimizing polymer nanogel and other supramolecular assemblies for various properties including, for example, particle size, density and morphology, guest loading capacity and encapsulation stability, and dynamic release control.
摘要翻译： 本发明提供了用于设计，选择，微调和优化聚合物纳米凝胶和其他超分子组合物的各种性能的强大的方法和组合物，包括例如粒度，密度和形态，客体负载能力和包封稳定性以及动态释放控制。
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公开(公告)号：US20230135432A1
公开(公告)日：2023-05-04
申请号：US18088544
申请日：2022-12-24
IPC分类号： A61K47/58 , A61P35/00 , C12N15/87 , C08F220/38 , C08F220/28 , A61K9/06 , A61K31/713
摘要： The invention provides polymers and polymeric nanogels in which nucleic acid molecules can be stably entrapped or encapsulated and are controllably delivered and released upon degradation of the nano-structures in response to specific microenvironment triggers, and compositions and methods of preparation and use thereof.
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公开(公告)号：US10131745B2
公开(公告)日：2018-11-20
申请号：US15841388
申请日：2017-12-14
摘要： The invention generally relates to novel polymers and polymeric nanogels having biodegradable polymeric backbones, and compositions and methods of preparation and use thereof, for example, as guest-host polymer nano-assemblies and nano-delivery vehicles, which offer utilities in diverse fields including drug delivery, diagnostics and specialty materials.
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10.发明申请公开(公告)号：US20180134845A1
公开(公告)日：2018-05-17
申请号：US15841388
申请日：2017-12-14
CPC分类号： C08G69/48 , A61K9/5146 , C08G69/10 , C08G69/26
摘要： The invention generally relates to novel polymers and polymeric nanogels having biodegradable polymeric backbones, and compositions and methods of preparation and use thereof, for example, as guest-host polymer nano-assemblies and nano-delivery vehicles, which offer utilities in diverse fields including drug delivery, diagnostics and specialty materials.
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