专利检索 ap:("UNIVERSITY OF PITTSBURGH-OF THE COMMONWEALTH SYSTEM OF HIGHER EDUCATION") AND inv:"Alexander DEITERS" 第 1 页

1.

发明公开
COVALENT APTAMERS 审中-公开

公开(公告)号：US20240255495A1

公开(公告)日：2024-08-01

申请号：US18557516

申请日：2022-04-26

申请人： UNIVERSITY OF PITTSBURGH-OF THE COMMONWEALTH SYSTEM OF HIGHER EDUCATION

发明人： Alexander DEITERS , Yaniv TIVON , Mary CACACE , Savannah ALBRIGHT

IPC分类号： G01N33/53 , C12N15/10 , C12N15/115 , G01N33/569 , G01N33/573 , G01N33/574 , G01N33/68

CPC分类号： G01N33/5308 , C12N15/1048 , C12N15/115 , G01N33/56983 , G01N33/573 , G01N33/57488 , G01N33/6851 , C12N2310/16 , C12N2310/314 , C12N2310/3511 , C12N2310/3517 , C12N2310/531 , G01N2333/165 , G01N2333/912 , G01N2333/974 , G01N2469/20

摘要： Disclosed are chemically modified aptamers comprising an electrophilic group and a handle and methods for using said aptamers to deliver the handle to a target protein, crosslink the aptamer to the target protein, as well as methods of using said aptamers to detect proteins and to treat viral infections or cancer.

2.

发明公开
CONDITIONAL CONTROL OF UNIVERSAL CAR T CELLS THROUGH STIMULUS-REACTIVE ADAPTORS 审中-公开

公开(公告)号：US20230414754A1

公开(公告)日：2023-12-28

申请号：US18035590

申请日：2021-11-05

申请人： UNIVERSITY OF PITTSBURGH-OF THE COMMONWEALTH SYSTEM OF HIGHER EDUCATION

发明人： Jason Jakob LOHMUELLER , Alexander DEITERS

IPC分类号： A61K39/00

CPC分类号： A61K39/4633 , A61K39/4631 , A61K39/4611 , A61K2239/26 , A61K2239/24

摘要： Disclosed are compositions and methods related to the construction and use of conditional universal synthetic notch (synNotch) receptors and conditional chimeric antigen receptor (CAR) T cells. Also disclosed herein are methods of using said synNotch receptors in the construction of engineered cells. It is contemplated herein that the disclosed synNotch receptors and engineered cells can be used in regenerative medicine. Additionally disclosed herein are methods of using the disclosed synNotch, CAR T cells, and engineered cells in the treatment of cancer, autoimmune disease, autoinflammatory disease, and infectious disease.

3.

发明申请
COVALENT ADAPTOR SYNNOTCH AND CHIMERIC ANTIGEN RECEPTORS (CARS) FOR PROGRAMMABLE ANTIGEN-TARGETING 有权

公开(公告)号：US20220267435A1

公开(公告)日：2022-08-25

申请号：US17282113

申请日：2019-10-03

申请人： UNIVERSITY OF PITTSBURGH-OF THE COMMONWEALTH SYSTEM OF HIGHER EDUCATION

发明人： Jason Jakob LOHMUELLER , Alexander DEITERS

IPC分类号： C07K16/28 , C07K14/705 , C07K14/725 , A61P35/00 , A61K35/17

摘要： Disclosed are compositions and methods related to the construction and use of universal synthetic notch (synNotch) receptors and chimeric antigen receptor (CAR) T cells.