公开(公告)号：US20230414528A1

公开(公告)日：2023-12-28

申请号：US18240743

申请日：2023-08-31

Applicant: UNIVERSITY OF SOUTH AUSTRALIA

Inventor： Ivan Mark KEMPSON ,  Tyron James TURNBULL

IPC: A61K9/51 ,  A61P35/00 ,  A61K33/242 ,  A61K41/00

CPC classification number: A61K9/5123 ,  A61P35/00 ,  B82Y5/00 ,  A61K41/0038 ,  A61K33/242

Abstract: Methods of potentiating chemotherapy or radiotherapy are disclosed. The methods comprise administering to a subject in need of chemotherapeutic or radiotherapeutic treatment an effective amount of a composition comprising biocompatible nanoparticles under conditions in which the nanoparticles alter one or more cell regulatory mechanisms in cells in which the nanoparticles are localised or other cells. Then one or more doses of a chemotherapeutic or radiotherapeutic treatment are administered to the subject either concurrently with or after the nanoparticles have altered the one or more cell regulatory mechanisms in the cells in which the nanoparticles are localised or other cells. Also disclosed are methods of enhancing the effects of chemotherapy or radiotherapy on a cell population, methods of increasing the amount of strand breaks in DNA in a cell, and methods of inducing cancer cell death.

公开(公告)号：US20230301930A1

公开(公告)日：2023-09-28

申请号：US18114409

申请日：2023-02-27

Applicant: UNIVERSITY OF SOUTH AUSTRALIA

Inventor： Ivan Mark KEMPSON ,  Tyron James TURNBULL

IPC: A61K9/51 ,  A61K33/242 ,  A61K41/00 ,  A61P35/00 ,  B82Y40/00 ,  B82Y5/00

CPC classification number: A61K9/5123 ,  A61K33/242 ,  A61K41/0038 ,  A61P35/00 ,  B82Y5/00 ,  B82Y40/00

Abstract: Methods of potentiating chemotherapy or radiotherapy are disclosed. The methods comprise administering to a subject in need of chemotherapeutic or radiotherapeutic treatment an effective amount of a composition comprising biocompatible nanoparticles under conditions in which the nanoparticles alter one or more cell regulatory mechanisms in cells in which the nanoparticles are localised or other cells. Then one or more doses of a chemotherapeutic or radiotherapeutic treatment are administered to the subject either concurrently with or after the nanoparticles have altered the one or more cell regulatory mechanisms in the cells in which the nanoparticles are localised or other cells. Also disclosed are methods of enhancing the effects of chemotherapy or radiotherapy on a cell population, methods of increasing the amount of strand breaks in DNA in a cell, and methods of inducing cancer cell death.

公开(公告)号：US20210000751A1

公开(公告)日：2021-01-07

申请号：US16758792

申请日：2018-10-26

Applicant: UNIVERSITY OF SOUTH AUSTRALIA

Inventor： Ivan Mark KEMPSON ,  Tyron James TURNBULL

IPC: A61K9/51 ,  A61K41/00 ,  A61K33/242 ,  A61P35/00

Abstract: Methods of potentiating chemotherapy or radiotherapy are disclosed. The methods comprise administering to a subject in need of chemotherapeutic or radiotherapeutic treatment an effective amount of a composition comprising biocompatible nanoparticles, particularly gold nanoparticles, under conditions in which the nanoparticles alter one or more cell regulatory mechanisms in cells in which the nanoparticles are localised or other cells. Then one or more doses of a chemotherapeutic or radiotherapeutic treatment are administered to the subject either concurrently with or after the nanoparticles have altered the one or more cell regulatory mechanisms in the cells in which the nanoparticles are localised or other cells. Also disclosed are methods of enhancing the effects of chemotherapy or radiotherapy on a cell population, methods of increasing the amount of strand breaks in DNA in a cell, and methods of inducing cancer cell death.