-
公开(公告)号：US20240343834A1
公开(公告)日：2024-10-17
申请号：US18507778
申请日：2023-11-13
发明人： David A. Eavarone , Jeffrey Behrens , Jillian M. Prendergast , Bo R. Rueda , Rosemary Foster , Kristen D. Starbuck
IPC分类号： C07K16/44 , A61K9/00 , A61K31/00 , A61K31/337 , A61K31/555 , A61K33/242 , A61K33/243 , A61K33/244 , A61K39/00 , A61K39/395 , A61K47/68 , A61P35/00 , G01N33/574
CPC分类号： C07K16/44 , A61K9/0019 , A61K31/00 , A61K31/337 , A61K31/555 , A61K33/242 , A61K33/243 , A61K39/39558 , A61K47/68031 , A61K47/6851 , A61K47/6869 , A61P35/00 , G01N33/57449 , A61K33/244 , A61K2039/505 , C07K2317/73 , G01N2400/00 , G01N2400/02
摘要： Compositions and methods for treating ovarian cancer are provided. Methods include combined treatment with chemotherapeutic agents and anti-STn antibodies. Chemotherapy resistant ovarian cancer cells may be reduced. Chemotherapy resistant ovarian cancer cells may include cancer stem cells.
-
2.发明公开公开(公告)号：US20240238443A1
公开(公告)日：2024-07-18
申请号：US18619103
申请日：2024-03-27
发明人： Taolei SUN
CPC分类号： A61K47/6929 , A61K31/28 , A61K33/242 , A61K47/54 , A61K47/542 , A61K47/64 , A61K47/69 , A61P27/02 , A61P27/06
摘要： Disclosed is the use of a gold cluster or a gold cluster-containing substance in the preparation of a drug for preventing and/or treating glaucoma.
-
公开(公告)号：US12036282B2
公开(公告)日：2024-07-16
申请号：US16770930
申请日：2018-12-06
发明人： Ewa Goldys , Wei Deng
IPC分类号： A61K41/00 , A61K9/00 , A61K9/127 , A61K31/519 , A61K31/704 , A61K31/7048 , A61K33/242 , A61K47/69 , A61K49/00 , A61N5/10 , C12N15/113
CPC分类号： A61K41/0071 , A61K9/0009 , A61K9/1271 , A61K9/1272 , A61K31/519 , A61K31/704 , A61K31/7048 , A61K33/242 , A61K47/6911 , A61K49/0021 , A61K49/0084 , A61N5/10 , C12N15/113 , A61N2005/1098 , C12N2310/11 , C12N2320/32 , C12N2320/35
摘要： A liposomal system for delivery of an active agent comprising: lipid component forming a liposome; destabilizing agent associated with the lipid component, the destabilizing agent capable of forming reactive oxygen species to oxidise unsaturated lipids and destabilise liposomal membrane; and an active agent; wherein the active agent is releasable from the liposome by exposure to high energy electromagnetic radiation.
-
公开(公告)号：US11938186B2
公开(公告)日：2024-03-26
申请号：US17325290
申请日：2021-05-20
IPC分类号： A61K47/32 , A61K9/06 , A61K9/127 , A61K31/704 , A61K33/242 , A61K41/00 , A61K47/34 , A61K47/42 , A61P35/00
CPC分类号： A61K41/0028 , A61K9/06 , A61K9/1271 , A61K31/704 , A61K33/242 , A61K47/32 , A61K47/34 , A61K47/42 , A61P35/00
摘要： The present invention provides for thermosensitive hydrogel for cancer therapeutic and methods of preparation thereof. The invention represents an advancement in the field of cancer therapeutics and provides for a polymer-protein based thermosensitive hydrogel comprising polyvinyl alcohol, poloxamer 407 and bovine serum albumin. The thermosensitive hydrogel can be optionally be enriched with one or more additional component such as photothermal agents, photosensitizers, drugs and dyes. The invention also provides for a method of preparing the thermosensitive hydrogels. The hydrogels of the present invention are inexpensive, thermosensitive, has ability to effectuate sustained release of drugs and can be used for targeted delivery and dual-modality treatment.
-
公开(公告)号：US11904021B2
公开(公告)日：2024-02-20
申请号：US17452041
申请日：2021-10-22
IPC分类号： A61K47/69 , A61K33/242 , A61K33/38 , A61K33/26 , A61P13/12 , A61K33/243 , A61K47/54 , A61K9/51 , A61K33/24
CPC分类号： A61K47/6929 , A61K9/5146 , A61K33/24 , A61K33/242 , A61K33/243 , A61K33/26 , A61K33/38 , A61K47/545 , A61P13/12
摘要： The subject invention pertains to compositions and methods for making and use of metal-based coated nanoparticles. The metal-based, PEG-coated nanoparticles of the invention comprise folic acid molecules on their surface exercise dual functionality by specifically targeting renal tubule cells and treating renal fibrosis.
-
公开(公告)号：US20230364132A1
公开(公告)日：2023-11-16
申请号：US18249530
申请日：2021-08-16
发明人： Taolei SUN
IPC分类号： A61K33/242 , A61K47/62 , A61P9/04 , A61K9/51
CPC分类号： A61K33/242 , A61K47/62 , A61P9/04 , A61K9/51
摘要： Ligand-bound gold clusters and compositions comprising the ligand-bound gold clusters are used for treating cerebral stroke and manufacturing a medicament for treatment of cerebral stroke. Methods for treating cerebral stroke.
-
公开(公告)号：US20230301908A1
公开(公告)日：2023-09-28
申请号：US18132144
申请日：2023-04-07
发明人： CHUN-HAN CHEN , WAN-YING GAO
IPC分类号： A61K9/08 , A61K47/61 , A61K47/54 , A61P27/02 , A61K33/242
CPC分类号： A61K9/08 , A61K33/242 , A61K47/545 , A61K47/61 , A61P27/02 , A61K9/0048
摘要： A contact lens product having an antioxidative function includes a composition in the form of a solution. The composition includes gold nanoparticles and at least one non-enzymatic antioxidant. The gold nanoparticles are present in an effective concentration from 0.01 ppm to 3000 ppm and have an average particle size from 0.5 nm to 40 nm. The at least one non-enzymatic antioxidant is present in an amount greater than 0 wt% and less than 20 wt% based on the composition being 100 wt%.
-
公开(公告)号：US20230248828A1
公开(公告)日：2023-08-10
申请号：US18194122
申请日：2023-03-31
IPC分类号： A61K41/00 , A61K47/69 , A61K33/242 , A61K33/243 , A61K33/24
CPC分类号： A61K41/0052 , A61K41/0028 , A61K47/6933 , A61K47/6923 , A61K47/6935 , A61K33/242 , A61K33/243 , A61K33/24
摘要： The field of the disclosure relates generally to cancer cell destruction and, more specifically, to cancer cell destruction by photo-magnetic irradiation mediated multimodal therapy using smart nanostructures.
-
9.发明授权公开(公告)号：US12098164B2
公开(公告)日：2024-09-24
申请号：US16663651
申请日：2019-10-25
申请人： CELLEMEDY CO., LTD
发明人： Jeewon Lee , Bo Ram Lee
IPC分类号： C07K14/005 , A61K9/51 , A61K33/242 , A61K38/00 , A61K38/38 , A61K49/00 , C07K16/18 , C12N7/00
CPC分类号： C07K14/005 , A61K9/5169 , A61K9/5184 , A61K33/242 , A61K38/38 , A61K49/0056 , A61K49/0093 , C07K16/18 , C12N7/00 , A61K38/00 , C07K2319/31 , C07K2319/735 , C12N2710/10032 , C12N2730/10122 , C12N2730/10123
摘要： The present invention relates to recombinant self-assembling protein nanoparticles presenting an albumin-binding peptide at the surface. For the recombinant self-assembling protein nanoparticles according to the present invention, an albumin-binding peptide can reduce the immunogenicity of the recombinant self-assembling protein nanoparticles because the albumin-binding peptide is presented at the surface, and thus binds to an albumin protein present in vivo, and the albumin-binding peptide can also provide the cancer delivery function of the recombinant self-assembling protein nanoparticles because the albumin-binding peptide binds to albumin around cancer. Simultaneously, the binding of the albumin-binding peptide to albumin can significantly increase the in vivo residence time of the recombinant self-assembling protein nanoparticles, thus increasing the potential for use in various medical applications.
-
10.发明公开公开(公告)号：US20240207197A1
公开(公告)日：2024-06-27
申请号：US18085433
申请日：2022-12-20
申请人： Alfaisal University
IPC分类号： A61K9/70 , A61K9/00 , A61K33/242 , A61K33/26 , A61K41/00
CPC分类号： A61K9/7007 , A61K9/0009 , A61K33/242 , A61K33/26 , A61K41/0052 , A61N5/067
摘要： A novel nanocomposite made of superparamagnetic nanoparticles, gold nanoparticles and reduced graphene oxide porous nanosheets is synthesized. The novelty of the nanocomposite lies in three main factors: the porosity of the reduced graphene oxide sheet, the magnetization of the superparamagnetic nanoparticles and the biocompatibility and near infrared absorbance of the gold nanoparticles all in one nanocomposite that does not disassemble when administered in the body. All of which are joined to create a whole and singular nanocomposite that can emit heat due to magnetic energy, become as biocompatible as possible and conceivably allow for near infrared absorbance penetration while the nanocomposite is fully assembled.
-
-
-
-
-
-
-
-
-
搜索结果
72 条记录 (耗时 0.032 秒)
