公开(公告)号：US20240344068A1

公开(公告)日：2024-10-17

申请号：US18622278

申请日：2024-03-29

申请人： UNIVERSITY OF SOUTH FLORIDA

发明人： Oksana Fihurka ,  Vasyl Sava ,  Juan Sanchez-Ramos

IPC分类号： C12N15/113 ,  A61K9/127 ,  A61K31/00 ,  A61K47/36 ,  A61P25/28

CPC分类号： C12N15/113 ,  A61K9/127 ,  A61K9/1278 ,  A61K31/658 ,  A61K47/36 ,  A61P25/28 ,  C12N2310/14 ,  C12N2310/315 ,  C12N2310/321

摘要： Disclosed herein are siRNAs, hybrid nanoparticles comprising the siRNAs, pharmaceutical compositions comprising the same, and methods of making and using the same to treat neurological diseases and disorders.

公开(公告)号：US10813913B2

公开(公告)日：2020-10-27

申请号：US16388661

申请日：2019-04-18

申请人： UNIVERSITY OF SOUTH FLORIDA ,  THE UNITED STATES GOVERNMENT AS REPRESENTED BY THE DEPARTMENT OF VETERANS AFFAIRS ,  H. LEE MOFFITT CANCER CENTER AND RESEARCH INSTITUTE INC.

发明人： Juan Sanchez-Ramos ,  Vasyl Sava ,  Shijie Song ,  Said Sebti

IPC分类号： A61K31/4174 ,  A61K31/53 ,  C07D233/60 ,  A61P25/28 ,  A61K38/19

摘要： Described herein are compound for the modulation of the G-CSF receptor. The compounds may act as agonists, antagonists, and/or mixed or partial agonists/antagonists of G-CSF. Further provided herein are methods of treating a condition, including, for example, a neurodegenerative disease, by administering a compound as detailed herein.

公开(公告)号：US20190247363A1

公开(公告)日：2019-08-15

申请号：US16388661

申请日：2019-04-18

申请人： UNIVERSITY OF SOUTH FLORIDA ,  THE UNITED STATES GOVERNMENT AS REPRESENTED BY THE DEPARTMENT OF VETERANS AFFAIRS

发明人： Juan Sanchez-Ramos ,  Vasyl Sava ,  Shijie Song ,  Said Sebti

IPC分类号： A61K31/4174 ,  A61K31/53 ,  C07D233/60 ,  A61P25/28 ,  A61K38/19

CPC分类号： A61K31/4174 ,  A61K31/53 ,  A61K38/193 ,  A61P25/28 ,  C07D233/60

摘要： Described herein are compound for the modulation of the G-CSF receptor. The compounds may act as agonists, antagonists, and/or mixed or partial agonists/antagonists of G-CSF. Further provided herein are methods of treating a condition, including, for example, a neurodegenerative disease, by administering a compound as detailed herein.

公开(公告)号：US10376495B2

公开(公告)日：2019-08-13

申请号：US15821634

申请日：2017-11-22

申请人： UNIVERSITY OF SOUTH FLORIDA ,  THE UNITED STATES GOVERNMENT AS REPRESENTED BY THE DEPARTMENT OF VETERANS AFFAIRS ,  H. LEE MOFFITT CANCER CENTER AND RESEARCH INSTRITUTE INC.

发明人： Juan Sanchez-Ramos ,  Vasyl Sava ,  Shijie Song ,  Said Sebti

IPC分类号： A61K31/4174 ,  C07D233/60 ,  A61K31/53 ,  A61K38/19 ,  A61P25/28

摘要： Described herein are compound for the modulation of the G-CSF receptor. The compounds may act as agonists, antagonists, and/or mixed or partial agonists/antagonists of G-CSF. Further provided herein are methods of treating a condition, including, for example, a neurodegenerative disease, by administering a compound as detailed herein.

公开(公告)号：US20180177763A1

公开(公告)日：2018-06-28

申请号：US15821634

申请日：2017-11-22

申请人： UNIVERSITY OF SOUTH FLORIDA ,  THE UNITED STATES GOVERNMENT AS REPRESENTED BY THE DEPARTMENT OF VETERANS AF

发明人： Juan Sanchez-Ramos ,  Vasyl Sava ,  Shijie Song ,  Said Sebti

IPC分类号： A61K31/4174 ,  C07D233/60 ,  A61K31/53 ,  A61K38/19 ,  A61P25/28

CPC分类号： A61K31/4174 ,  A61K31/53 ,  A61K38/193 ,  A61P25/28 ,  C07D233/60

摘要： Described herein are compound for the modulation of the G-CSF receptor. The compounds may act as agonists, antagonists, and/or mixed or partial agonists/antagonists of G-CSF. Further provided herein are methods of treating a condition, including, for example, a neurodegenerative disease, by administering a compound as detailed herein.