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1.发明申请公开(公告)号：US20180177763A1
公开(公告)日：2018-06-28
申请号：US15821634
申请日：2017-11-22
申请人： UNIVERSITY OF SOUTH FLORIDA , THE UNITED STATES GOVERNMENT AS REPRESENTED BY THE DEPARTMENT OF VETERANS AF
发明人： Juan Sanchez-Ramos , Vasyl Sava , Shijie Song , Said Sebti
IPC分类号： A61K31/4174 , C07D233/60 , A61K31/53 , A61K38/19 , A61P25/28
CPC分类号： A61K31/4174 , A61K31/53 , A61K38/193 , A61P25/28 , C07D233/60
摘要： Described herein are compound for the modulation of the G-CSF receptor. The compounds may act as agonists, antagonists, and/or mixed or partial agonists/antagonists of G-CSF. Further provided herein are methods of treating a condition, including, for example, a neurodegenerative disease, by administering a compound as detailed herein.
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公开(公告)号：US20220233132A1
公开(公告)日：2022-07-28
申请号：US17582396
申请日：2022-01-24
发明人： Stephanie Lutton Carey , Arsany Boles Gad , Jordyn Elizabeth Bizzell , Juan Sanchez-Ramos , Sang-Hie Lee , Ying Zhong
摘要： One or more EMG sensors are configured to sense surface-EMG data indicative of muscle movement of the patient; and transmit surface-EMG data. A controller can identify at least one parameter of the surface-EMG data; compare the parameter to a corresponding dystonia-threshold-value; responsive to a determination that the parameter is greater than the corresponding dystonia-threshold-value: issue a visual-engagement command to a visual unit; and issue a tactile-engagement command to a tactile unit.
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3.发明公开公开(公告)号：US20240344068A1
公开(公告)日：2024-10-17
申请号：US18622278
申请日：2024-03-29
发明人： Oksana Fihurka , Vasyl Sava , Juan Sanchez-Ramos
IPC分类号： C12N15/113 , A61K9/127 , A61K31/00 , A61K47/36 , A61P25/28
CPC分类号： C12N15/113 , A61K9/127 , A61K9/1278 , A61K31/658 , A61K47/36 , A61P25/28 , C12N2310/14 , C12N2310/315 , C12N2310/321
摘要： Disclosed herein are siRNAs, hybrid nanoparticles comprising the siRNAs, pharmaceutical compositions comprising the same, and methods of making and using the same to treat neurological diseases and disorders.
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公开(公告)号：US09795637B1
公开(公告)日：2017-10-24
申请号：US13647934
申请日：2012-10-09
CPC分类号： A61K35/30 , A61K35/12 , A61K35/51 , A61K2035/124 , C12N5/0618 , C12N2501/13 , C12N2501/385 , C12N2506/1369
摘要： The present invention relates to the use of umbilical cord blood cells from a donor or patient to provide neural cells which may be used in transplantation. The isolated cells according to the present invention may be used to effect autologous and allogeneic transplantation and repair of neural tissue, in particular, tissue of the brain and spinal cord and to treat neurodegenerative diseases of the brain and spinal cord.
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5.发明授权公开(公告)号：US10813913B2
公开(公告)日：2020-10-27
申请号：US16388661
申请日：2019-04-18
申请人： UNIVERSITY OF SOUTH FLORIDA , THE UNITED STATES GOVERNMENT AS REPRESENTED BY THE DEPARTMENT OF VETERANS AFFAIRS , H. LEE MOFFITT CANCER CENTER AND RESEARCH INSTITUTE INC.
发明人： Juan Sanchez-Ramos , Vasyl Sava , Shijie Song , Said Sebti
IPC分类号： A61K31/4174 , A61K31/53 , C07D233/60 , A61P25/28 , A61K38/19
摘要： Described herein are compound for the modulation of the G-CSF receptor. The compounds may act as agonists, antagonists, and/or mixed or partial agonists/antagonists of G-CSF. Further provided herein are methods of treating a condition, including, for example, a neurodegenerative disease, by administering a compound as detailed herein.
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6.发明申请公开(公告)号：US20190247363A1
公开(公告)日：2019-08-15
申请号：US16388661
申请日：2019-04-18
申请人： UNIVERSITY OF SOUTH FLORIDA , THE UNITED STATES GOVERNMENT AS REPRESENTED BY THE DEPARTMENT OF VETERANS AFFAIRS
发明人： Juan Sanchez-Ramos , Vasyl Sava , Shijie Song , Said Sebti
IPC分类号： A61K31/4174 , A61K31/53 , C07D233/60 , A61P25/28 , A61K38/19
CPC分类号： A61K31/4174 , A61K31/53 , A61K38/193 , A61P25/28 , C07D233/60
摘要： Described herein are compound for the modulation of the G-CSF receptor. The compounds may act as agonists, antagonists, and/or mixed or partial agonists/antagonists of G-CSF. Further provided herein are methods of treating a condition, including, for example, a neurodegenerative disease, by administering a compound as detailed herein.
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7.发明授权公开(公告)号：US10376495B2
公开(公告)日：2019-08-13
申请号：US15821634
申请日：2017-11-22
申请人： UNIVERSITY OF SOUTH FLORIDA , THE UNITED STATES GOVERNMENT AS REPRESENTED BY THE DEPARTMENT OF VETERANS AFFAIRS , H. LEE MOFFITT CANCER CENTER AND RESEARCH INSTRITUTE INC.
发明人： Juan Sanchez-Ramos , Vasyl Sava , Shijie Song , Said Sebti
IPC分类号： A61K31/4174 , C07D233/60 , A61K31/53 , A61K38/19 , A61P25/28
摘要： Described herein are compound for the modulation of the G-CSF receptor. The compounds may act as agonists, antagonists, and/or mixed or partial agonists/antagonists of G-CSF. Further provided herein are methods of treating a condition, including, for example, a neurodegenerative disease, by administering a compound as detailed herein.
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