公开(公告)号：US10736933B2

公开(公告)日：2020-08-11

申请号：US15774681

申请日：2016-11-09

Applicant: UNIVERSITY OF SOUTHAMPTON

Inventor： Salim Iqbal Khakoo

IPC: A61K38/03 ,  C07K14/18 ,  C12N5/0783 ,  A61K35/17 ,  C12N15/62

Abstract: The invention relates to a peptide capable of activating NK cell-mediated immunity, the peptide comprising or consisting of the amino acid sequence XnAX2X1, Wherein Xn is an amino acid sequence of between 5 and 12 residues, and X1 is any amino acid; or leucine or phenylalanine; and X2 is alanine, threonine or serine. The invention further relates to an MHC class I molecule and the peptide, nucleic acids encoding the peptide, activated NK cells, and related compositions and methods, including use in methods of treatment.

公开(公告)号：US20220096614A1

公开(公告)日：2022-03-31

申请号：US17440067

申请日：2020-03-23

Applicant: University of Southampton

Inventor： Salim Iqbal Khakoo

IPC: A61K39/00 ,  G01N33/574 ,  C12N5/0783 ,  A61P35/00

Abstract: The invention relates to a method of treatment or prophylaxis of cancer, wherein the cancer overexpresses exportin-1, the method comprising the administration of: a peptide capable of activating NK cell-mediated immunity to cancer cells that overexpress exportin-1, the peptide comprising or consisting of the amino acid sequence XnAX2X1, wherein Xn is an amino acid sequence of between 5 and 12 residues, and X1 is any amino acid; or leucine or phenylalanine; and X2 is alanine, threonine or serine; or administration of one or more of a nucleic acid encoding the peptide; an immunogenic composition comprising the peptide; a complex comprising the peptide; a vesicle comprising the peptide or nucleic acid encoding the peptide; a dendritic cell comprising the peptide and/or comprising nucleic acid encoding the peptide; an activated NK cell, that has been activated by the peptide; or a virus or virus like particle comprising the peptide and/or comprising nucleic acid encoding the peptide.

公开(公告)号：US20170137466A1

公开(公告)日：2017-05-18

申请号：US15310014

申请日：2015-05-08

Applicant: University of Southampton

Inventor： Salim Iqbal Khakoo

IPC: C07K7/06 ,  C12N7/00 ,  C07K14/74 ,  C12N5/0783 ,  C12Q1/68

CPC classification number: C07K7/06 ,  A61K38/00 ,  C07K14/70539 ,  C07K2319/70 ,  C12N5/0646 ,  C12N7/00 ,  C12N2501/998 ,  C12Q1/6883 ,  Y02A50/411

Abstract: This invention relates to NK cell activation and NK cell mediated immunity, immunogenic peptides, compositions and complexes; and associated methods of treatment or prophylaxis. In particular, a peptide capable of activating NK cell-mediated immunity, the peptide comprising or consisting of the amino acid sequence XnAX2X1 wherein Xn is an amino acid sequence of between 5 and 12 residues, and X1 is any amino acid; or leucine or isoleucine; and X2 is alanine, threonine, tryptophan, or serine.

公开(公告)号：US10995116B2

公开(公告)日：2021-05-04

申请号：US15310014

申请日：2015-05-08

Applicant: University of Southampton

Inventor： Salim Iqbal Khakoo

IPC: C07K7/06 ,  C12N5/0783 ,  C07K14/74 ,  C12N7/00 ,  C12Q1/6883 ,  A61K38/00

Abstract: This invention relates to NK cell activation and NK cell mediated immunity, immunogenic peptides, compositions and complexes; and associated methods of treatment or prophylaxis. In particular, a peptide capable of activating NK cell-mediated immunity, the peptide comprising or consisting of the amino acid sequence XnAX2X1 wherein Xn is an amino acid sequence of between 5 and 12 residues, and X1 is any amino acid; or leucine or isoleucine; and X2 is alanine, threonine, tryptophan, or serine.