公开(公告)号：US20220203029A1

公开(公告)日：2022-06-30

申请号：US17611323

申请日：2020-05-14

Applicant: UNIVERSITY OF VIRGINIA PATENT FOUNDATION

Inventor： Marc D. Breton ,  Jose Garcia-Tirado ,  Patricio Colmegna ,  John Corbett

IPC: A61M5/172 ,  G16H50/20 ,  A61B5/00 ,  A61B5/145 ,  G16H20/17

Abstract: Provided are a system and method for an artificial pancreas having multi-stage model predictive control to minimize and/or prevent occurrence of hypoglycemia associated with Type 1 diabetes. The control implements predictive modeling of a probability of glucose uptake associated with exercise based on at least one exercise profile for a subject with Type 1 diabetes. Based on the probability, the control implements an automatic adjustment of basal insulin infusion to counteract a risk of exercise-induced hypoglycemia in advance of the subject engaging in the exercise. The control implements adjustment of such infusion based on real-time signaling of exercise likely to induce hypoglycemia. The control implements adjustment of a meal-time bolus to account for delay in glucose uptake resulting from exercise engaged in by the subject. Consequently, the control acts to minimize and/or prevent hypoglycemia from occurring both during and immediately after exercise.