公开(公告)号：US12017045B2

公开(公告)日：2024-06-25

申请号：US17502346

申请日：2021-10-15

Applicant: UNIVERSITY OF VIRGINIA PATENT FOUNDATION

Inventor： Stephen D. Patek ,  Marc D. Breton

IPC: A61M5/172 ,  A61B5/145 ,  A61M5/142 ,  G16H10/60 ,  G16H20/17 ,  G16H40/67 ,  A61K38/28

CPC classification number: A61M5/1723 ,  A61B5/14532 ,  A61M5/14244 ,  G16H10/60 ,  G16H20/17 ,  G16H40/67 ,  A61K38/28 ,  A61M2205/3303 ,  A61M2205/3584 ,  A61M2205/502 ,  A61M2205/52

Abstract: Equivalent insulin pump retrospective virtual basal rates for daily injections are constructed from planned insulin injections according to a virtual basal rate profile developed for a patient, and a database of historical insulin injections, i.e. basal injections actually administered by the patient, providing a unified framework for analysis, design, optimization, and adaptation of MDI (multiple daily injections) and CSII (continuous subcutaneous insulin infusion (i.e. insulin pump)) treatment parameters for patients with diabetes.

公开(公告)号：US11722229B2

公开(公告)日：2023-08-08

申请号：US17156169

申请日：2021-01-22

Applicant: ABBOTT DIABETES CARE INC. ,  UNIVERSITY OF VIRGINIA PATENT FOUNDATION

Inventor： Marc D. Breton ,  Boris P. Kovatchev ,  Erwin S. Budiman ,  Kenneth J. Doniger

IPC: H04B17/00 ,  A61B5/145 ,  A61B5/00 ,  A61B5/1473 ,  G16H40/60 ,  G16H40/67 ,  G16H10/40

CPC classification number: H04B17/00 ,  A61B5/002 ,  A61B5/14503 ,  A61B5/14532 ,  A61B5/14546 ,  A61B5/1473 ,  A61B2560/0223 ,  G16H10/40 ,  G16H40/60 ,  G16H40/67

Abstract: Method, system and computer program product for providing real time detection of analyte sensor sensitivity decline is continuous glucose monitoring systems are provided.

公开(公告)号：US11666287B2

公开(公告)日：2023-06-06

申请号：US16577398

申请日：2019-09-20

Applicant: UNIVERSITY OF VIRGINIA PATENT FOUNDATION

Inventor： Marc D. Breton ,  Najib Ben-Brahim

IPC: A61B5/0205 ,  A61B5/00 ,  A61B5/145 ,  A61M5/172 ,  G16H40/67 ,  G16H50/20 ,  A61B5/11 ,  A61M5/142

CPC classification number: A61B5/7275 ,  A61B5/0205 ,  A61B5/14532 ,  A61B5/4839 ,  A61B5/7264 ,  A61M5/1723 ,  G16H40/67 ,  G16H50/20 ,  A61B5/1118 ,  A61B5/7225 ,  A61B2562/0219 ,  A61M2005/14208 ,  A61M2205/3303 ,  A61M2205/3327 ,  A61M2205/35 ,  A61M2205/3561 ,  A61M2205/505 ,  A61M2205/52

Abstract: A system for generating a hypoglycemia risk signal associated with exercise-induced Hypoglycemia. The system can include a processor configured to obtain a blood glucose signal (BGstart), a ratio of absolute insulin on board over total daily insulin signal (IOBabs/TDI), and an initial glycemic slope signal (S0); generate a hypoglycemia risk signal based on a hypoglycemia prediction algorithm that determines the probability of a user being hypoglycemic during or after exercise based on the obtained BGstarts, IOBabs/TDI and S0.

公开(公告)号：US20200214629A1

公开(公告)日：2020-07-09

申请号：US16789901

申请日：2020-02-13

Applicant: University of Virginia Patent Foundation

Inventor： Boris P. Kovatchev ,  Patrick T. Keith-Hynes ,  Marc D. Breton ,  Stephen D. Patek

IPC: A61B5/00 ,  G16H50/20 ,  G16H50/30 ,  A61M5/172 ,  A61M5/168 ,  A61K38/28 ,  A61B5/11 ,  A61B5/0402 ,  A61B5/021 ,  A61B5/0205 ,  A61B5/145

Abstract: A flexible system for utilizing data from different monitoring techniques and capable of providing assistance to patients with diabetes at several scalable levels, ranging from advice about long-term trends and prognosis to real-time automated closed-loop control (artificial pancreas). These scalable monitoring and treatment strategies are delivered by a unified system called the Diabetes Assistant (DiAs) platform. The system provides a foundation for implementation of various monitoring, advisory, and automated diabetes treatment algorithms or methods. The DiAs recommendations are tailored to the specifics of an individual patient, and to the patient risk assessment at any given moment.

公开(公告)号：US10463789B2

公开(公告)日：2019-11-05

申请号：US15255828

申请日：2016-09-02

Applicant: University of Virginia Patent Foundation

Inventor： Marc D. Breton ,  Boyi Jiang ,  Chiara Fabris

IPC: A61M5/172 ,  A61B5/145 ,  A61B5/00 ,  G06F19/00 ,  G16H40/63 ,  G16H50/20 ,  A61M5/142

Abstract: A technique for treating diabetes that recognizes patient insulin sensitivity is a time-varying physiological parameter. The described techniques for treating diabetes include measuring interstitial fluid glucose concentration, reading insulin delivery data, determining patient insulin sensitivity based on the interstitial fluid glucose concentration and insulin delivery data, and a time-varying physiological parameter, and dispensing an insulin dose from an insulin delivery device based on the determined patient insulin sensitivity.

公开(公告)号：US20190019571A1

公开(公告)日：2019-01-17

申请号：US16126879

申请日：2018-09-10

Applicant: University of Virginia Patent Foundation

Inventor： Marc D. Breton ,  Boris P. Kovatchev

IPC: G16H10/40 ,  G16H50/30 ,  G06F19/00 ,  G16H50/50 ,  G16H40/63

Abstract: A method, system and computer program product for evaluating or determining a user's insulin sensitivity (SI). An initial step or module may include acquiring SMBG readings from a predetermined period. Another step or module may include computing an estimate of insulin sensitivity (SI) from the SMBG readings. Another step or module may include using the estimate of SI to compute individualized carbohydrate ratio. Additionally, another step or module may include using the estimate of SI to compute individualized correction factor. The computation of the two components of an insulin dose calculator, carbohydrate ratio and correction factor, uses this estimate, which allows the tailoring of carbohydrate ratio and correction factor to the present state of the person.

公开(公告)号：US20180313815A1

公开(公告)日：2018-11-01

申请号：US15580915

申请日：2016-06-08

Applicant: University of Virginia Patent Foundation

Inventor： Boris P. Kovatchev ,  Marc D. Breton

IPC: G01N33/49 ,  A61B5/00

CPC classification number: G06F19/3468 ,  A61B5/14532 ,  G06F19/00

Abstract: A computer-implemented method for providing a real-time estimate of glycosylated hemoglobin (HbAlc) of a patient from a self-monitoring blood glucose (SMBG) measurement, and tracking changes in average glycemia of said patient over time is disclosed. The method includes the steps of; a computer computing a surrogate fasting measurement based on SMBG data received from the patient; a computer computing a glycation value using the said surrogate fasting measurement in a predetermined glycation equation; a computer outputting said glycation value as an initial estimate of HbAlc upon initialization of tracking of said patient's average glycemia; a computer updating said glycation value by using an updated SMBG value in said predetermined glycation equation, said updated SMBG value being based on a subsequent computed surrogate fasting measurement; and a computer computing an updated estimate of HbAlc using said initial estimate of HbAlc and said updated glycation value in a predetermined HbAlc estimation equation.

公开(公告)号：US20170056591A1

公开(公告)日：2017-03-02

申请号：US15255828

申请日：2016-09-02

Applicant: University of Virginia Patent Foundation

Inventor： Marc D. Breton ,  Boyi Jiang ,  Chiara Fabris

IPC: A61M5/172 ,  G06F19/00 ,  A61B5/145 ,  A61B5/00 ,  A61M5/142 ,  A61M5/178

CPC classification number: A61M5/1723 ,  A61B5/1451 ,  A61B5/14532 ,  A61B5/4839 ,  A61B5/7275 ,  A61M2005/14208 ,  A61M2230/201 ,  G06F19/3456 ,  G06F19/3462 ,  G06F19/3468 ,  G16H40/63 ,  G16H50/20

Abstract: A technique for treating diabetes that recognizes patient insulin sensitivity is a time-varying physiological parameter. The described techniques for treating diabetes include measuring interstitial fluid glucose concentration, reading insulin delivery data, determining patient insulin sensitivity based on the interstitial fluid glucose concentration and insulin delivery data, and a time-varying physiological parameter, and dispensing an insulin dose from an insulin delivery device based on the determined patient insulin sensitivity.

Abstract translation: 用于治疗识别患者胰岛素敏感性的糖尿病的技术是时变生理参数。 所描述的用于治疗糖尿病的技术包括测量间质液葡萄糖浓度，读取胰岛素递送数据，基于间质液葡萄糖浓度和胰岛素递送数据确定患者胰岛素敏感性，以及时变生理参数，以及从胰岛素分配胰岛素剂量 基于确定的患者胰岛素敏感性的递送装置。

公开(公告)号：US20150193589A1

公开(公告)日：2015-07-09

申请号：US14419375

申请日：2013-08-05

Applicant: University of Virginia Patent Foundation

Inventor： Edward A. Ortiz ,  Stephen D. Patek ,  Marc D. Breton ,  Leon S. Farhi ,  Boris P. Kovatchev

IPC: G06F19/00

CPC classification number: G16H50/50 ,  C12Q1/54

Abstract: Time-varying hyperglycemic stresses are derived from actual ICU patients and applied to non-critically ill virtual patients, using any model of normal glucose-insulin physiology that fulfills certain requirements, in order to model and simulate stress hyperglycemia. Other aspects provide: 1) a methodology to perform sensitivity analyses of the parameters of ICU insulin infusion therapy protocols and to improve the protocols; and 2) a training system for clinicians about the course and management of stress hyperglycemia in the ICU or other facility.

Abstract translation: 随时间变化的高血糖应激来自实际的ICU患者，并应用于非危重症虚拟患者，使用任何符合某些要求的正常葡萄糖 - 胰岛素生理模型，以模拟和模拟应激性高血糖。 其他方面提供：1）对ICU胰岛素输注治疗方案参数进行灵敏度分析的方法，并改进方案; 和2）临床医生关于ICU或其他设施中压力高血糖过程和管理的培训系统。

公开(公告)号：US12057233B2

公开(公告)日：2024-08-06

申请号：US17696466

申请日：2022-03-16

Applicant: UNIVERSITY OF VIRGINIA PATENT FOUNDATION

Inventor： Stephen D. Patek ,  Marc D. Breton

IPC: G16H50/50 ,  G16H10/60 ,  G16H40/63 ,  G16H50/70

CPC classification number: G16H50/50 ,  G16H10/60 ,  G16H40/63 ,  G16H50/70

Abstract: A method and system use mathematical models and available patient information to virtualize a continuous glucose monitoring trace for a period of time. Such a method and system can generate the virtualized trace when episodic patient data is incomplete. Such a method and system can also rely on self-monitored blood glucose measurement information to improve the virtualized continuous glucose monitoring trace.