公开(公告)号：US20240285832A1

公开(公告)日：2024-08-29

申请号：US18585241

申请日：2024-02-23

申请人： UNIVERSITY-INDUSTRY COOPERATION GROUP OF KYUNG HEE UNIVERSITY ,  RESEARCH & BUSINESS FOUNDATION SUNGKYUNKWAN UNIVERSITY

发明人： Sung Min RHEE ,  Jae Yun KIM ,  Pil Seon IM

IPC分类号： A61L27/56 ,  A61L27/26 ,  A61L27/58

CPC分类号： A61L27/56 ,  A61L27/26 ,  A61L27/58 ,  A61L2430/10

摘要： The present disclosure relates to a scaffold with atelocollagen inserted into a porous hyaluronic acid polymer for treatment and recovery of tendon or ligament diseases. The scaffold enhances the efficacy of hyaluronic acid and atelocollagen through slow and prolonged secretion at the suture site, thereby creating a synergistic effect. Additionally, the porous scaffold with high mechanical properties binds the suture site of a ruptured tendon and provides a microenvironment for the regeneration process of surrounding cells, thereby making it useful for the treatment and recovery of tendon or ligament diseases.

公开(公告)号：US20230068334A1

公开(公告)日：2023-03-02

申请号：US17700758

申请日：2022-03-22

申请人： RESEARCH & BUSINESS FOUNDATION SUNGKYUNKWAN UNIVERSITY

发明人： Jae Yun KIM ,  Donghwan JI

IPC分类号： C08J3/075 ,  B01J13/00 ,  C08G61/12 ,  C08K3/22 ,  C08K3/26

摘要： A method for preparing a hydrogel includes forming a pre-gel comprising polymer and metal salt particles, unidirectionally-shrinking and dehydrating the pre-gel, and impregnating the unidirectionally shrunk and dehydrated pre-gel with an ion solution to crosslink and rehydrate the unidirectionally shrunk and dehydrated pre-gel to produce the hydrogel.

公开(公告)号：US20190129069A1

公开(公告)日：2019-05-02

申请号：US16220734

申请日：2018-12-14

申请人： Research & Business Foundation Sungkyunkwan University

发明人： Jae Yun KIM ,  Bong Guen CHA ,  Seung Woo CHOI

IPC分类号： G02B1/04 ,  C08G77/38 ,  C08J7/16 ,  G02C7/04

摘要： The present disclosure relates to a contact lens containing ceria particles. Further, the present disclosure relates to a method for manufacturing a contact lens containing ceria particles. The method includes preparing ceria particles; preparing poly-2-hydroxyethyl methacrylate (PHEMA or poly-HEMA) in a form of cross-linked hydrogel; mixing the ceria particles and the monomer mixture for poly-2-hydroxyethyl methacrylate (PHEMA or poly-HEMA) with each other to form a mixture; and injecting the mixture in a mold having a contact lens shape; and performing photo-curing polymerization of the mixture. The contact lens effectively eliminates the reactive oxygen species and harmful radicals that are identified as a cause of eye diseases.

公开(公告)号：US20210260556A1

公开(公告)日：2021-08-26

申请号：US17168490

申请日：2021-02-05

申请人： Research & Business Foundation Sungkyunkwan University

发明人： Jae Yun KIM ,  Donghwan JI

IPC分类号： B01J13/00 ,  C08J3/075 ,  C08K7/18 ,  C08J3/24 ,  A61L31/14 ,  C08K3/16 ,  C08K3/22

摘要： The present disclosure relates to a method for preparing a restructured hydrogel, including forming a hydrogel containing a first polymer, unidirectionally shrinking and dehydrating the hydrogel, and additionally cross-linking and rehydrating the dehydrated hydrogel.

公开(公告)号：US20210113675A1

公开(公告)日：2021-04-22

申请号：US17073656

申请日：2020-10-19

申请人： Research & Business Foundation Sungkyunkwan University

发明人： Jae Yun KIM ,  Nguyen Thanh LOC

IPC分类号： A61K39/00 ,  A61K9/14

摘要： The present invention relates to a dual-scale porous silica particle-based pharmaceutical composition for preventing or treating cancer, which includes porous silica nanoparticles and porous silica microparticles. The pharmaceutical composition of the present invention promotes the generation of a larger amount of antigen-specific, cytotoxic T cells against cancer than a mesoporous silica nanoparticle (MSN) vaccine, and exhibits increased anti-tumor efficacy compared with a mesoporous silica microrod (MSR) vaccine.