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公开(公告)号:US20250089722A1
公开(公告)日:2025-03-20
申请号:US18963593
申请日:2024-11-28
Applicant: T3 BIOSCIENCE, INC. , UWM RESEARCH FOUNDATION, INC.
Inventor: Ching-Hong Yang , Jian Huang
Abstract: The present disclosure concerns methods of using novel bacterial strains of 0617-T307, 0917-T305, 0917-T306, 0917-T307, 0118-T319, 0318-T327, and 0418-T328, and the cell broth and novel metabolites produced from the bacterial strains, to inhibit the growth of a variety of pathogenic microorganism for a variety of crops. This method is effective against a broad range of fungal pathogens, including Pythium aphanidermatum, Podosphaera xanthii, Plasmopara viticola, Erysiphe cichoracearum, Pseudoperonospora cubensis, Clarireedia jacksonii, Microdochium nivale, and Podosphaera leucotricha. The methods include the application of Formula (I) in various formulations to inhibit pathogenic microorganisms in crops such as cucurbits, legumes, leafy greens, root vegetables, oilseed crops, ornamental plants, fruit crops, and turfgrass. The methods include the use of an agricultural composition including a novel, potent antimicrobial metabolite produced from the bacterial strains corresponding to the compound having Formula (I):
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公开(公告)号:US20230285472A1
公开(公告)日:2023-09-14
申请号:US18120528
申请日:2023-03-13
Applicant: T3 BIOSCIENCE, LLC , UWM RESEARCH FOUNDATION, INC.
Inventor: Ching-Hong Yang , Jian Huang
Abstract: The present invention relates to an antimicrobial composition and probiotics against bacterial and fungal pathogens of fish. In particular, the invention pertains to a novel strain of the bacterial species Pseudomonas chlororaphis subsp. aurantiaca 1214-CHY4 (ATCC accession number PTA-126941), the cells, cell broth, and novel metabolites produced from the bacterial strain that can inhibit the growth of a variety of fish pathogens.
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公开(公告)号:US11590115B2
公开(公告)日:2023-02-28
申请号:US17494068
申请日:2021-10-05
Applicant: T3 BIOSCIENCE, LLC , UWM RESEARCH FOUNDATION, INC.
Inventor: Ching-Hong Yang , Jian Huang
IPC: A61K31/04 , A61K31/4412 , A61P31/04 , A61K35/74
Abstract: The present disclosure concerns methods of using novel bacterial strains of 0617-T307, 0917-T305, 0917-T306, 0917-T307, 0118-T319, 0318-T327, and 0418-T328, the cell broth and novel metabolites produced from the bacterial strains, that can inhibit the growth of a variety of fish pathogens. The methods include use of novel, potent antimicrobial metabolites produced from the strains corresponding to a compound having Formula (I):
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公开(公告)号:US20220105080A1
公开(公告)日:2022-04-07
申请号:US17494068
申请日:2021-10-05
Applicant: T3 BIOSCIENCE, LLC , UWM RESEARCH FOUNDATION, INC.
Inventor: Ching-Hong Yang , Jian Huang
IPC: A61K31/4412 , A61K35/74 , A61P31/04
Abstract: The present disclosure concerns methods of using novel bacterial strains of 0617-T307, 0917-T305, 0917-T306, 0917-T307, 0118-T319, 0318-T327, and 0418-T328, the cell broth and novel metabolites produced from the bacterial strains, that can inhibit the growth of a variety of fish pathogens. The methods include use of novel, potent antimicrobial metabolites produced from the strains corresponding to a compound having Formula (I):
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5.
公开(公告)号:US20230309565A1
公开(公告)日:2023-10-05
申请号:US18120799
申请日:2023-03-13
Applicant: T3 BIOSCIENCE, LLC , UWM RESEARCH FOUNDATION, INC.
Inventor: Ching-Hong Yang , Jian Huang
Abstract: The present disclosure concerns methods of using novel bacterial strains of 0617-T307, 0917-T305, 0917-T306, 0917-T307, 0118-T319, 0318-T327, and 0418-T328, the cell broth and novel metabolites produced from the bacterial strains, to inhibit the growth of a variety of microbial species for bacterial pathogens that cause citrus Huanglongbing (citrus greening disease), Zebra chip (ZC) disease of potato, tomato, and other plants of the family Solanaceae and plants of the family Apiaceae and Umbelliferae. The methods include use of novel, potent antimicrobial metabolites produced from the strains corresponding to a Pseudomonas bacterial metabolite as Formula (I):
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公开(公告)号:US20220104487A1
公开(公告)日:2022-04-07
申请号:US17493594
申请日:2021-10-04
Applicant: T3 BIOSCIENCE, LLC , UWM RESEARCH FOUNDATION, INC.
Inventor: Ching-Hong Yang , Jian Huang
Abstract: The present disclosure concerns methods of using novel bacterial strains of 0617-T307, 0917-T305, 0917-T306, 0917-T307, 0118-T319, 0318-T327, and 0418-T328, the cell broth and novel metabolites produced from the bacterial strains, that can inhibit the growth of a variety of microbial species for a variety of crops and fungal pathogens. The methods include use of novel, potent antimicrobial metabolites produced from the strains corresponding to compounds having Formulas (I), (II), and (III):
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公开(公告)号:US12121552B2
公开(公告)日:2024-10-22
申请号:US18120528
申请日:2023-03-13
Applicant: T3 Bioscience, Inc. , UWM RESEARCH FOUNDATION, INC.
Inventor: Ching-Hong Yang , Jian Huang
Abstract: The present invention relates to an antimicrobial composition and probiotics against bacterial and fungal pathogens of fish. In particular, the invention pertains to a novel strain of the bacterial species Pseudomonas chlororaphis subsp. aurantiaca 1214-CHY4 (ATCC accession number PTA-126941), the cells, cell broth, and novel metabolites produced from the bacterial strain that can inhibit the growth of a variety of fish pathogens.
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公开(公告)号:US12089595B2
公开(公告)日:2024-09-17
申请号:US17493594
申请日:2021-10-04
Applicant: T3 Bioscience, Inc. , UWM RESEARCH FOUNDATION, INC.
Inventor: Ching-Hong Yang , Jian Huang
Abstract: The present disclosure concerns methods of using novel bacterial strains of 0617-T307, 0917-T305, 0917-T306, 0917-T307, 0118-T319, 0318-T327, and 0418-T328, the cell broth and novel metabolites produced from the bacterial strains, that can inhibit the growth of a variety of microbial species for a variety of crops and fungal pathogens. The methods include use of novel, potent antimicrobial metabolites produced from the strains corresponding to compounds having Formulas (I), (II), and (III):
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公开(公告)号:US20190112618A1
公开(公告)日:2019-04-18
申请号:US15748939
申请日:2016-07-29
Applicant: UWM Research Foundation, Inc.
Inventor: Dazhong Zhao , Jian Huang
IPC: C12N15/82 , C12N15/113
Abstract: Disclosed herein are compositions and methods for creating sterile plants by genetically ablating microspore and megaspore mother cells. Also disclosed herein are methods of restoring fertility of sterile male and female plants.
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