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1.发明授权Autoantigenes for improved diagnosis, prognosis and treatment of inflammatory neurological diseases 失效用于改善炎症性神经疾病的诊断，预后和治疗的自身抗原公开(公告)号：US08399210B2
公开(公告)日：2013-03-19
申请号：US12420627
申请日：2009-04-08
申请人： Ugur Sahin , Özlem Türeci , Alexander Zaigler
发明人： Ugur Sahin , Özlem Türeci , Alexander Zaigler
IPC分类号： G01N33/53 , G01N33/537 , G01N33/567
CPC分类号： G01N33/564 , G01N33/56972 , G01N2800/285
摘要： According to the invention, autoantibodies, the appearance of which is characteristic of neurological autoimmune diseases, especially multiple sclerosis, are detected and the respective autoantigens identified. It can further be shown that many of these autoantigens are expressed specifically in the brain. The identification of the autoantigens and autoantibodies is useful for diagnosis and treatment. A brain-specific expression of the autoantigens further emphasizes an important role of the antigens and antibodies in the origin and development of neurological autoimmune diseases.
摘要翻译： 根据本发明，检测其外观是神经性自身免疫性疾病，特别是多发性硬化症的特征的自身抗体，并鉴定出相应的自身抗原。 可以进一步表明，许多这些自身抗原在脑中特异性表达。 自身抗体和自身抗体的鉴定对于诊断和治疗是有用的。 自身抗原的脑特异性表达进一步强调了抗原和抗体在神经性自身免疫性疾病的起源和发展中的重要作用。
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2.发明申请Autoantigenes for Improved Diagnosis, Prognosis and Treatment of Inflammatory Neurological Diseases 失效用于改善炎症性神经疾病诊断，预后和治疗的自身抗原公开(公告)号：US20090252714A1
公开(公告)日：2009-10-08
申请号：US12420627
申请日：2009-04-08
申请人： Ugur Sahin , Ozlem Tureci , Alexander Zaigler
发明人： Ugur Sahin , Ozlem Tureci , Alexander Zaigler
IPC分类号： A61K48/00 , G01N33/566 , A61K38/17 , A61K31/711 , A61P25/00 , A61P25/28
CPC分类号： G01N33/564 , G01N33/56972 , G01N2800/285
摘要： According to the invention, autoantibodies, the appearance of which is characteristic of neurological autoimmune diseases, especially multiple sclerosis, are detected and the respective autoantigens identified. It can further be shown that many of these autoantigens are expressed specifically in the brain. The identification of the autoantigens and autoantibodies is useful for diagnosis and treatment. A brain-specific expression of the autoantigens further emphasizes an important role of the antigens and antibodies in the origin and development of neurological autoimmune diseases.
摘要翻译： 根据本发明，检测其外观是神经性自身免疫性疾病，特别是多发性硬化症的特征的自身抗体，并鉴定出相应的自身抗原。 可以进一步表明，许多这些自身抗原在脑中特异性表达。 自身抗体和自身抗体的鉴定对于诊断和治疗是有用的。 自身抗原的脑特异性表达进一步强调了抗原和抗体在神经性自身免疫性疾病的起源和发展中的重要作用。
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