-
1.发明授权公开(公告)号：US09044382B2
公开(公告)日：2015-06-02
申请号：US11596649
申请日：2005-05-18
IPC分类号： A61K6/00 , C07K14/47 , C07K14/705 , C07K16/30 , C12N9/88 , G01N33/574 , A61K49/00 , A61K39/00
CPC分类号： A61K6/00 , A61K47/6851 , A61K49/00 , A61K2039/505 , C07K14/47 , C07K14/705 , C07K16/18 , C07K16/28 , C07K16/30 , C07K16/303 , C07K16/3046 , C07K16/3076 , C07K16/44 , C07K2317/24 , C07K2317/34 , C07K2317/73 , C07K2317/75 , C12N9/88 , C12Y406/01002 , G01N33/57496
摘要： According to the invention, gene products expressed in a tumor-associated manner and the nucleic acids coding therefor were identified. The invention relates to the therapy and diagnosis of diseases wherein said gene products expressed in a tumor-associated manner are aberrantly expressed. The invention also relates to proteins, polypeptides and peptides which are expressed in a tumor associated manner and to nucleic acids coding therefor.
摘要翻译： 根据本发明，鉴定了以肿瘤相关方式表达的基因产物和其编码的核酸。 本发明涉及疾病的治疗和诊断，其中以肿瘤相关方式表达的所述基因产物被异常表达。 本发明还涉及以肿瘤相关方式表达的蛋白质，多肽和肽以及编码它们的核酸。
-
公开(公告)号：US08716455B2
公开(公告)日：2014-05-06
申请号：US12197960
申请日：2008-08-25
申请人： Ugur Sahin , Özlem Türeci , Michael Koslowski
发明人： Ugur Sahin , Özlem Türeci , Michael Koslowski
IPC分类号： C07K16/00
CPC分类号： C07K16/30 , A61K38/00 , A61K39/00 , A61K39/39558 , A61K48/00 , C07K14/4748 , C07K16/3015 , C07K16/3023 , C07K16/3053 , C07K16/3069 , C07K2317/34 , C07K2317/76 , C12Q1/6886 , C12Q2600/112 , C12Q2600/158 , G01N33/574
摘要： The invention relates to the identification of genetic products that are expressed in association with a tumor and the nucleic acid coding therefor. The invention relates to the therapy and diagnosis of diseases in which said genetic products that are expressed in association with a tumor are expressed in an aberrant manner. The invention also relates to proteins, polypeptides, and peptides which are expressed in association with a tumor and the nucleic acids coding therefor.
摘要翻译： 本发明涉及与肿瘤相关表达的遗传产物的鉴定及其编码的核酸。 本发明涉及以异常方式表达与肿瘤相关表达的所述遗传产物的疾病的治疗和诊断。 本发明还涉及与肿瘤相关的表达的蛋白质，多肽和肽以及编码它们的核酸。
-
3.发明授权Autoantigenes for improved diagnosis, prognosis and treatment of inflammatory neurological diseases 失效用于改善炎症性神经疾病的诊断，预后和治疗的自身抗原公开(公告)号：US08399210B2
公开(公告)日：2013-03-19
申请号：US12420627
申请日：2009-04-08
申请人： Ugur Sahin , Özlem Türeci , Alexander Zaigler
发明人： Ugur Sahin , Özlem Türeci , Alexander Zaigler
IPC分类号： G01N33/53 , G01N33/537 , G01N33/567
CPC分类号： G01N33/564 , G01N33/56972 , G01N2800/285
摘要： According to the invention, autoantibodies, the appearance of which is characteristic of neurological autoimmune diseases, especially multiple sclerosis, are detected and the respective autoantigens identified. It can further be shown that many of these autoantigens are expressed specifically in the brain. The identification of the autoantigens and autoantibodies is useful for diagnosis and treatment. A brain-specific expression of the autoantigens further emphasizes an important role of the antigens and antibodies in the origin and development of neurological autoimmune diseases.
摘要翻译： 根据本发明，检测其外观是神经性自身免疫性疾病，特别是多发性硬化症的特征的自身抗体，并鉴定出相应的自身抗原。 可以进一步表明，许多这些自身抗原在脑中特异性表达。 自身抗体和自身抗体的鉴定对于诊断和治疗是有用的。 自身抗原的脑特异性表达进一步强调了抗原和抗体在神经性自身免疫性疾病的起源和发展中的重要作用。
-
公开(公告)号：US20120014948A1
公开(公告)日：2012-01-19
申请号：US13184719
申请日：2011-07-18
申请人： Ugur Sahin , Özlem Türeci , Michael Koslowski
发明人： Ugur Sahin , Özlem Türeci , Michael Koslowski
IPC分类号： A61K39/395 , A61P35/00
CPC分类号： C07K16/30 , A61K38/00 , A61K39/00 , A61K39/39558 , A61K48/00 , C07K14/4748 , C07K16/3015 , C07K16/3023 , C07K16/3053 , C07K16/3069 , C07K2317/34 , C07K2317/76 , C12Q1/6886 , C12Q2600/112 , C12Q2600/158 , G01N33/574
摘要： The invention relates to the identification of genetic products that are expressed in association with a tumor and the nucleic acid coding therefor. The invention relates to the therapy and diagnosis of diseases in which the genetic products that are expressed in association with a tumor are expressed in an aberrant manner. The invention also relates to proteins, polypeptides, and peptides which are expressed in association with a tumor and the nucleic acids coding therefor.
摘要翻译： 本发明涉及与肿瘤相关表达的遗传产物的鉴定及其编码的核酸。 本发明涉及以异常方式表达与肿瘤相关表达的遗传产物的疾病的治疗和诊断。 本发明还涉及与肿瘤相关的表达的蛋白质，多肽和肽以及编码它们的核酸。
-
公开(公告)号：US08088913B2
公开(公告)日：2012-01-03
申请号：US12096216
申请日：2006-12-07
申请人： Ugur Sahin , Özlem Türeci , Michael Koslowski
发明人： Ugur Sahin , Özlem Türeci , Michael Koslowski
CPC分类号： C12N15/1138 , C07K14/4748 , C12N15/1137 , C12N2310/14 , C12Y301/03048
摘要： The present invention is directed to siRNA molecules which specifically target and cause RNAi-induced degradation of mRNA from TPTE genes, so that the protein product of the TPTE gene is not produced or is produced in reduced amounts. The siRNA compounds and compositions of the invention are useful for treating diseases which require inhibition of TPTE expression for their treatment, in particular cancer pathologies. The present invention also includes methods which make possible to assess and/or prognose the metastatic behavior of a cancer disease and/or the occurrence of a relapse of cancer.
摘要翻译： 本发明涉及特异性靶向并引起来自TPTE基因的mRNA的RNAi诱导的降解的siRNA分子，使得TPTE基因的蛋白质产物不产生或以减少的量产生。 本发明的siRNA化合物和组合物可用于治疗需要抑制TPTE表达以治疗，特别是癌症病症的疾病。 本发明还包括使得有可能评估和/或预测癌症疾病的转移行为和/或癌症复发的方法。
-
6.发明申请公开(公告)号：US20110014628A1
公开(公告)日：2011-01-20
申请号：US12851980
申请日：2010-08-06
申请人： Özlem TÜRECI , Ugur SAHIN , Sandra SCHNEIDER , Gerd HELFTENBEIN , Volker SCHLÜTER , Dirk USENER , Philippe THIEL , Michael KOSLOWSKI
发明人： Özlem TÜRECI , Ugur SAHIN , Sandra SCHNEIDER , Gerd HELFTENBEIN , Volker SCHLÜTER , Dirk USENER , Philippe THIEL , Michael KOSLOWSKI
CPC分类号： A61K39/39558 , A61K39/395 , A61K45/06 , C07K14/4748 , C07K16/28 , C07K16/30 , C12Q1/6886 , C12Q2600/106 , C12Q2600/156 , G01N33/53
摘要： An isolated truncated desmoglein 4 (DSG4) polypeptide splice variant of the invention is characterized by an amino acid sequence that lacks a region encoded before exon 9 or beyond exon 10 of the DSG4 gene having the polynucleotide sequence of SEQ ID NO: 75. Also disclosed is a method of diagnosing a cancer, or monitoring the course thereof, in a patient. The method comprises detecting in a tissue sample of a patient the expression of a tumor-associated antigen comprising the extracellular domain of a DSG4 polypeptide encoded by a DSG4 gene having the polynucleotide sequence of SEQ ID NO: 75, or a truncated DSG4 polypeptide splice variant characterized by an amino acid sequence that lacks a region encoded before exon 9 or beyond exon 10 of the DSG4 gene.
摘要翻译： 本发明的分离的截短的脱骨髓蛋白4（DSG4）多肽剪接变体的特征在于缺乏在具有SEQ ID NO：75的多核苷酸序列的DSG4基因的外显子9或超出外显子10之前编码的区域的氨基酸序列。还公开了 是在患者中诊断癌症或监测其过程的方法。 该方法包括在患者的组织样品中检测包含由具有SEQ ID NO：75的多核苷酸序列的DSG4基因或截短的DSG4多肽剪接变体编码的DSG4多肽的细胞外结构域的肿瘤相关抗原的表达 其特征在于缺乏在DSG4基因的外显子9或超出外显子10之前编码的区域的氨基酸序列。
-
公开(公告)号：US09809815B2
公开(公告)日：2017-11-07
申请号：US13201702
申请日：2010-02-19
申请人： Ugur Sahin , Özlem Türeci , Michael Koslowski , Gerd Helftenbein , Korden Walter , Stefan Wöll , Gabriela-Elena Oprea
发明人： Ugur Sahin , Özlem Türeci , Michael Koslowski , Gerd Helftenbein , Korden Walter , Stefan Wöll , Gabriela-Elena Oprea
IPC分类号： G01N1/00 , G01N33/574 , C12N15/113 , A61K31/7088
CPC分类号： C12N15/113 , A61K31/7088
摘要： The present invention relates to the identification of nucleic acid and amino acid sequences that are characteristic of tumor tissues such as ovarian tumor and lung tumor tissues and which represent targets for therapy or diagnosis of tumor diseases in a subject.
-
8.发明授权公开(公告)号：US08637012B2
公开(公告)日：2014-01-28
申请号：US13296620
申请日：2011-11-15
申请人： Ugur Sahin , Özlem Türeci , Michael Koslowski
发明人： Ugur Sahin , Özlem Türeci , Michael Koslowski
IPC分类号： A61K39/395 , A61K39/00
CPC分类号： C07K16/3076 , A61K47/48569 , A61K47/549 , A61K2039/505 , C07K14/47 , C07K16/18 , C07K16/30 , C07K16/3023 , C07K16/3046 , C07K2317/30 , C07K2317/34 , G01N33/57484
摘要： The invention relates to the identification of genetic products expressed in association with tumors and to coding nucleic acids for the expressed products. An embodiment of the invention also relates to the therapy and diagnosis of disease in which the genetic products are aberrantly expressed in association with tumors, proteins, polypeptides and peptides which are expressed in association with tumors, and to the nucleic acids coding for the polypeptides, peptides and proteins.
摘要翻译： 本发明涉及与肿瘤相关表达的遗传产物的鉴定和用于表达产物的编码核酸。 本发明的一个实施方案还涉及其中遗传产物与肿瘤相关表达的肿瘤，蛋白质，多肽和肽异常表达的疾病的治疗和诊断，以及编码多肽的核酸， 肽和蛋白质。
-
公开(公告)号：US08637006B2
公开(公告)日：2014-01-28
申请号：US13471606
申请日：2012-05-15
申请人： Özlem Türeci , Ugur Sahin , Sebastian Kreiter
发明人： Özlem Türeci , Ugur Sahin , Sebastian Kreiter
CPC分类号： A61K47/64 , A61K48/00 , C07K14/4748 , C07K14/70539 , C07K2319/02 , C07K2319/03
摘要： The present invention relates to fusion molecules of antigens, the nucleic acids coding therefor and the use of such fusion molecules and nucleic acids. In particular, said invention relates to fusion molecules, comprising an antigen and the trans-membrane region and cytoplasmic region of a MHC molecule and/or the cytoplasmic region of a MHC or a SNARE molecule.
摘要翻译： 本发明涉及抗原的融合分子，其编码的核酸以及这种融合分子和核酸的使用。 特别地，本发明涉及融合分子，其包含MHC或SNARE分子的MHC分子和/或细胞质区域的抗原和跨膜区域和胞质区域。
-
10.发明申请公开(公告)号：US20120258091A1
公开(公告)日：2012-10-11
申请号：US13296620
申请日：2011-11-15
申请人： Ugur Sahin , Özlem Türeci , Michael Koslowski
发明人： Ugur Sahin , Özlem Türeci , Michael Koslowski
IPC分类号： A61K39/395 , A61P35/00 , C07K16/30
CPC分类号： C07K16/3076 , A61K47/48569 , A61K47/549 , A61K2039/505 , C07K14/47 , C07K16/18 , C07K16/30 , C07K16/3023 , C07K16/3046 , C07K2317/30 , C07K2317/34 , G01N33/57484
摘要： The invention relates to the identification of genetic products expressed in association with tumors and to coding nucleic acids for the expressed products. An embodiment of the invention also relates to the therapy and diagnosis of disease in which the genetic products are aberrantly expressed in association with tumors, proteins, polypeptides and peptides which are expressed in association with tumors, and to the nucleic acids coding for the polypeptides, peptides and proteins.
摘要翻译： 本发明涉及与肿瘤相关表达的遗传产物的鉴定和用于表达产物的编码核酸。 本发明的一个实施方案还涉及其中遗传产物与肿瘤相关表达的肿瘤，蛋白质，多肽和肽异常表达的疾病的治疗和诊断，以及编码多肽的核酸， 肽和蛋白质。
-
-
-
-
-
-
-
-
-
搜索结果
39 条记录 (耗时 0.031 秒)
