公开(公告)号：US10738355B2

公开(公告)日：2020-08-11

申请号：US14119348

申请日：2012-05-23

申请人： Ugur Sahin ,  Sebastian Kreiter ,  Mustafa Diken ,  Jan Diekmann ,  Michael Koslowski ,  Cedrik Britten ,  John Christopher Castle ,  Martin Lower ,  Bernhard Renard ,  Tana Omokoko ,  Johannes Hendrikus De Graaf

发明人： Ugur Sahin ,  Sebastian Kreiter ,  Mustafa Diken ,  Jan Diekmann ,  Michael Koslowski ,  Cedrik Britten ,  John Christopher Castle ,  Martin Lower ,  Bernhard Renard ,  Tana Omokoko ,  Johannes Hendrikus De Graaf

IPC分类号： C12Q1/6869 ,  A61K39/00 ,  G16B20/00 ,  G16B40/00 ,  C12Q1/6886

摘要： The present invention relates to the provision of vaccines which are specific for a patient's tumor and are potentially useful for immunotherapy of the primary tumor as well as tumor metastases. In one aspect, the present invention relates to a method for providing an individualized cancer vaccine comprising the steps: (a) identifying cancer specific somatic mutations in a tumor specimen of a cancer patient to provide a cancer mutation signature of the patient; and (b) providing a vaccine featuring the cancer mutation signature obtained in step (a). In a further aspect, the present invention relates to vaccines which are obtainable by said method.

公开(公告)号：US20140178438A1

公开(公告)日：2014-06-26

申请号：US14119348

申请日：2012-05-23

申请人： Ugur Sahin ,  Sebastian Kreiter ,  Mustafa Diken ,  Jan Diekmann ,  Michael Koslowski ,  Cedrik Britten ,  John Christopher Castle ,  Martin Lower ,  Bernhard Renard ,  Tana Omokoko ,  Johannes Hendrikus De Graaf

发明人： Ugur Sahin ,  Sebastian Kreiter ,  Mustafa Diken ,  Jan Diekmann ,  Michael Koslowski ,  Cedrik Britten ,  John Christopher Castle ,  Martin Lower ,  Bernhard Renard ,  Tana Omokoko ,  Johannes Hendrikus De Graaf

IPC分类号： C12Q1/68

摘要： The present invention relates to the provision of vaccines which are specific for a patient's tumor and are potentially useful for immunotherapy of the primary tumor as well as tumor metastases. In one aspect, the present invention relates to a method for providing an individualized cancer vaccine comprising the steps: (a) identifying cancer specific somatic mutations in a tumor specimen of a cancer patient to provide a cancer mutation signature of the patient; and (b) providing a vaccine featuring the cancer mutation signature obtained in step (a). In a further aspect, the present invention relates to vaccines which are obtainable by said method.

摘要翻译： 本发明涉及提供对患者肿瘤特异的疫苗，并且可能用于原发性肿瘤的免疫治疗以及肿瘤转移。 一方面，本发明涉及提供个体化癌症疫苗的方法，其包括以下步骤：（a）鉴定癌症患者的肿瘤标本中的癌症特异性体细胞突变，以提供患者的癌症突变特征; 和（b）提供特征在步骤（a）中获得的癌症突变特征的疫苗。 另一方面，本发明涉及可通过所述方法获得的疫苗。