公开(公告)号：US20170112911A1

公开(公告)日：2017-04-27

申请号：US15392677

申请日：2016-12-28

申请人： Ugur Sahin ,  Ozlem Tureci ,  Petra Simon ,  Tana Omokoko

发明人： Ugur Sahin ,  Ozlem Tureci ,  Petra Simon ,  Tana Omokoko

IPC分类号： A61K39/00 ,  C12N5/0783 ,  G01N33/50 ,  C12N9/16 ,  C07K14/725

CPC分类号： A61K39/0011 ,  A61K39/12 ,  A61K2039/53 ,  A61K2039/57 ,  C07K14/005 ,  C07K14/4748 ,  C07K14/705 ,  C07K14/70503 ,  C07K14/7051 ,  C12N5/0636 ,  C12N9/16 ,  C12N15/85 ,  C12N2510/00 ,  C12N2710/16134 ,  C12Y301/03048 ,  G01N33/5017 ,  G01N2333/916

摘要： The present invention relates to efficient methods for providing antigen-specific lymphoid cells. These lymphoid cells may be used to provide antigen specific T cell receptors having a defined MHC restriction and to identify immunologically relevant T cell epitopes. Furthermore, the present invention relates to antigen-specific T cell receptors and T cell epitopes and their use in immunotherapy.

公开(公告)号：US20190060430A1

公开(公告)日：2019-02-28

申请号：US16121414

申请日：2018-09-04

申请人： Ugur Sahin ,  Ozlem Tureci ,  Petra Simon ,  Tana Omokoko

发明人： Ugur Sahin ,  Ozlem Tureci ,  Petra Simon ,  Tana Omokoko

IPC分类号： A61K39/00 ,  C12N15/85 ,  C07K14/705 ,  C12N5/0783 ,  G01N33/50 ,  C12N9/16 ,  A61K39/12 ,  C07K14/005 ,  C07K14/725 ,  C07K14/47

摘要： The present invention relates to efficient methods for providing antigen-specific lymphoid cells. These lymphoid cells may be used to provide antigen specific T cell receptors having a defined MHC restriction and to identify immunologically relevant T cell epitopes. Furthermore, the present invention relates to antigen-specific T cell receptors and T cell epitopes and their use in immunotherapy.

公开(公告)号：US10738355B2

公开(公告)日：2020-08-11

申请号：US14119348

申请日：2012-05-23

申请人： Ugur Sahin ,  Sebastian Kreiter ,  Mustafa Diken ,  Jan Diekmann ,  Michael Koslowski ,  Cedrik Britten ,  John Christopher Castle ,  Martin Lower ,  Bernhard Renard ,  Tana Omokoko ,  Johannes Hendrikus De Graaf

发明人： Ugur Sahin ,  Sebastian Kreiter ,  Mustafa Diken ,  Jan Diekmann ,  Michael Koslowski ,  Cedrik Britten ,  John Christopher Castle ,  Martin Lower ,  Bernhard Renard ,  Tana Omokoko ,  Johannes Hendrikus De Graaf

IPC分类号： C12Q1/6869 ,  A61K39/00 ,  G16B20/00 ,  G16B40/00 ,  C12Q1/6886

摘要： The present invention relates to the provision of vaccines which are specific for a patient's tumor and are potentially useful for immunotherapy of the primary tumor as well as tumor metastases. In one aspect, the present invention relates to a method for providing an individualized cancer vaccine comprising the steps: (a) identifying cancer specific somatic mutations in a tumor specimen of a cancer patient to provide a cancer mutation signature of the patient; and (b) providing a vaccine featuring the cancer mutation signature obtained in step (a). In a further aspect, the present invention relates to vaccines which are obtainable by said method.

公开(公告)号：US10117918B2

公开(公告)日：2018-11-06

申请号：US15392677

申请日：2016-12-28

申请人： Ugur Sahin ,  Ozlem Tureci ,  Petra Simon ,  Tana Omokoko

发明人： Ugur Sahin ,  Ozlem Tureci ,  Petra Simon ,  Tana Omokoko

IPC分类号： C12N5/0783 ,  A61K39/00 ,  C12N9/16 ,  C07K14/725 ,  G01N33/50

摘要： The present invention relates to efficient methods for providing antigen-specific lymphoid cells. These lymphoid cells may be used to provide antigen specific T cell receptors having a defined MHC restriction and to identify immunologically relevant T cell epitopes. Furthermore, the present invention relates to antigen-specific T cell receptors and T cell epitopes and their use in immunotherapy.

公开(公告)号：US09586997B2

公开(公告)日：2017-03-07

申请号：US13823079

申请日：2011-09-19

申请人： Ugur Sahin ,  Ozlem Tureci ,  Petra Simon ,  Tana Omokoko

发明人： Ugur Sahin ,  Ozlem Tureci ,  Petra Simon ,  Tana Omokoko

IPC分类号： C12N5/0783 ,  C07K14/005 ,  A61K39/00 ,  C07K14/47 ,  C07K14/725 ,  C07K14/705 ,  C12N15/85 ,  A61K39/12

CPC分类号： A61K39/0011 ,  A61K39/12 ,  A61K2039/53 ,  A61K2039/57 ,  C07K14/005 ,  C07K14/4748 ,  C07K14/705 ,  C07K14/70503 ,  C07K14/7051 ,  C12N5/0636 ,  C12N9/16 ,  C12N15/85 ,  C12N2510/00 ,  C12N2710/16134 ,  C12Y301/03048 ,  G01N33/5017 ,  G01N2333/916

摘要： The present invention relates to efficient methods for providing antigen-specific lymphoid cells. These lymphoid cells may be used to provide antigen specific T cell receptors having a defined MHC restriction and to identify immunologically relevant T cell epitopes. Furthermore, the present invention relates to antigen-specific T cell receptors and T cell epitopes and their use in immunotherapy.

摘要翻译： 本发明涉及提供抗原特异性淋巴细胞的有效方法。 这些淋巴细胞可用于提供具有限定的MHC限制的抗原特异性T细胞受体并鉴定免疫相关的T细胞表位。 此外，本发明涉及抗原特异性T细胞受体和T细胞表位及其在免疫治疗中的用途。

公开(公告)号：US20140178438A1

公开(公告)日：2014-06-26

申请号：US14119348

申请日：2012-05-23

申请人： Ugur Sahin ,  Sebastian Kreiter ,  Mustafa Diken ,  Jan Diekmann ,  Michael Koslowski ,  Cedrik Britten ,  John Christopher Castle ,  Martin Lower ,  Bernhard Renard ,  Tana Omokoko ,  Johannes Hendrikus De Graaf

发明人： Ugur Sahin ,  Sebastian Kreiter ,  Mustafa Diken ,  Jan Diekmann ,  Michael Koslowski ,  Cedrik Britten ,  John Christopher Castle ,  Martin Lower ,  Bernhard Renard ,  Tana Omokoko ,  Johannes Hendrikus De Graaf

IPC分类号： C12Q1/68

摘要： The present invention relates to the provision of vaccines which are specific for a patient's tumor and are potentially useful for immunotherapy of the primary tumor as well as tumor metastases. In one aspect, the present invention relates to a method for providing an individualized cancer vaccine comprising the steps: (a) identifying cancer specific somatic mutations in a tumor specimen of a cancer patient to provide a cancer mutation signature of the patient; and (b) providing a vaccine featuring the cancer mutation signature obtained in step (a). In a further aspect, the present invention relates to vaccines which are obtainable by said method.

摘要翻译： 本发明涉及提供对患者肿瘤特异的疫苗，并且可能用于原发性肿瘤的免疫治疗以及肿瘤转移。 一方面，本发明涉及提供个体化癌症疫苗的方法，其包括以下步骤：（a）鉴定癌症患者的肿瘤标本中的癌症特异性体细胞突变，以提供患者的癌症突变特征; 和（b）提供特征在步骤（a）中获得的癌症突变特征的疫苗。 另一方面，本发明涉及可通过所述方法获得的疫苗。

公开(公告)号：US20130273647A1

公开(公告)日：2013-10-17

申请号：US13823079

申请日：2011-09-19

申请人： Ugur Sahin ,  Ozlem Tureci ,  Petra Simon ,  Tana Omokoko

发明人： Ugur Sahin ,  Ozlem Tureci ,  Petra Simon ,  Tana Omokoko

IPC分类号： C07K14/005 ,  C07K14/705 ,  C12N15/85 ,  C12N5/0783

CPC分类号： A61K39/0011 ,  A61K39/12 ,  A61K2039/53 ,  A61K2039/57 ,  C07K14/005 ,  C07K14/4748 ,  C07K14/705 ,  C07K14/70503 ,  C07K14/7051 ,  C12N5/0636 ,  C12N9/16 ,  C12N15/85 ,  C12N2510/00 ,  C12N2710/16134 ,  C12Y301/03048 ,  G01N33/5017 ,  G01N2333/916

摘要： The present invention relates to efficient methods for providing antigen-specific lymphoid cells. These lymphoid cells may be used to provide antigen specific T cell receptors having a defined MHC restriction and to identify immunologically relevant T cell epitopes. Furthermore, the present invention relates to antigen-specific T cell receptors and T cell epitopes and their use in immunotherapy.

摘要翻译： 本发明涉及提供抗原特异性淋巴细胞的有效方法。 这些淋巴细胞可用于提供具有限定的MHC限制的抗原特异性T细胞受体并鉴定免疫相关的T细胞表位。 此外，本发明涉及抗原特异性T细胞受体和T细胞表位及其在免疫治疗中的用途。